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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCR4 | 1233 | chemokine (C-C motif) receptor 4 | 3 | CC-CKR-4, CMKBR4, CKR4, k5-5, ChemR13, CD194 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23649168 | 2013 | Cell line : HT 29, AZ 97 Source : - Sample Type : - No. of Sample : - Stage : - | real RT-PCR, flow cytometry,ELISA and G-LISA assays,Migration assays | Up-regulation | - | CCL17-CCR4 axis might be involved in the spread of colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Chemokine receptors : C-C motif, "CD molecules" |
| Description | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3p24-p21.3 |
| Start | 32993066 |
| End | 32996403 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3338 |
| OMIM ID | 604836 |
| HGNC ID | HGNC:1605 |
| Unigene ID | Hs.184926 |
| Ensembl ID | ENSG00000183813 |
| PharmGKB ID | PA26169 |
mRNA Information
| mRNA ID | NM_005508.4 |
|---|---|
| Exon | join(1..117,1799..3338) | mRNA Sequence | Download Select all |
| Length | 1657 |
Protein Information
| Protein ID | NP_005499.1 |
|---|---|
| Protein Name | chemokine (C-C motif) receptor 4 |
| Molecular Wt. (Da) | 41272 |
| Protein Sequence | Download Select all |
| Length | 360 |
| Uniprot ID | Q14982 |
| Ensembl Protein ID | ENSP00000330862 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 156 | ADRBK1 | 182 | NP_001610.2 | in vivo | 10754297 |
| 157 | ADRBK2 | 183 | NP_005151.2 | in vivo | 10754297 |
| 6348 | CCL3 | 1656 | NP_002974.1 | in vitro | 8573157 |
| 6352 | CCL5 | 1751 | NP_002976.2 | in vitro;in vivo | 122 701 188 573 157 |
| 6361 | CCL17 | 3309 | NP_002978.1 | in vitro;in vivo | 94 307 249 169 480 |
| 6367 | CCL22 | 4263 | NP_002981.2 | in vivo | 943 072 499 335 899 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 50-256 | 7TM_GPCR_Srsx |
| cl21561 | 50-256 | 7tm_4 superfamily |
| PHA03087 | 1-313 | PHA03087 |
| PHA02638 | 16-320 | PHA02638 |
| PHA02834 | 41-328 | PHA02834 |
| pfam00001 | 62-304 | 7tm_1 |
| PHA03235 | 44-320 | PHA03235 |
Ontology Information
| HPRD ID | 4024 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Ion transporter activity (GO:0015075) |
| Biological Process | Ion transport (GO:0006811) |
Drug Information
No matching records could be found.