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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CD109 | 135228 | CD109 molecule | 6 | FLJ38569, DKFZp762L1111, CPAMD7 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24475022 | 2014 | Cell line : - Source : Shiraz University Hospital, Shiraz, Iran. Sample Type : CRC tumor and normal tissue No. of Sample : 27 Stage : - | Array CGH,MSI analysis,Methylation-specific PCR,Comparative genomic hybridization | Methylation | - | Seven markers with moderate to high frequency of methylation (SYNE1, MMP2, CD109, EVL, RET, LGR and PTPRD). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] | Chromosome | 6 |
| Location | 6q14.1 |
| Start | 74405508 |
| End | 74538041 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 132534 |
| OMIM ID | 608859 |
| HGNC ID | HGNC:21685 |
| Unigene ID | Hs.399891 |
| Ensembl ID | ENSG00000156535 |
| PharmGKB ID | PA134949237 |
Protein Information
| Protein ID | NP_001153059.1 |
|---|---|
| Protein Name | CD109 molecule |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1445 |
| Uniprot ID | Q8N695 |
| Ensembl Protein ID | ENSP00000445340 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 581 |
| S | Phosphorylation | 585 |
| N | Glycosylation | 118 |
| N | Glycosylation | 68 |
| N | Glycosylation | 419 |
| N | Glycosylation | 247 |
| Y | Phosphorylation | 467 |
| S | Phosphorylation | 579 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02897 | 907-1194 | A2M_2 |
| cl08267 | 907-1194 | ISOPREN_C2_like superfamily |
| cd02891 | 907-1194 | A2M_like |
| cd02896 | 907-1194 | complement_C3_C4_C5 |
| cd00688 | 907-1194 | ISOPREN_C2_like |
| pfam00207 | 693-782 | A2M |
| cl08251 | 693-782 | A2M superfamily |
| pfam07677 | 1311-1395 | A2M_recep |
| cl08457 | 1311-1395 | A2M_recep superfamily |
| pfam07703 | 468-599 | A2M_N_2 |
| cl19929 | 468-599 | A2M_N superfamily |
| pfam01835 | 130-221 | A2M_N |
| cl19929 | 130-221 | A2M_N superfamily |
| pfam10569 | 910-940 | Thiol-ester_cl |
| cl10467 | 910-940 | Thiol-ester_cl superfamily |
| pfam11974 | 15-111 | MG1 |
| cl13419 | 15-111 | MG1 superfamily |
| pfam07678 | 959-1196 | A2M_comp |
| COG2373 | 66-1000 | YfaS |
| pfam13249 | 968-1077 | Prenyltrans_2 |
Ontology Information
| HPRD ID | 10568 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.