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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21633598 | 2011 | Cell line : - Source : Han Chinese in a case-control study. Sample Type : Population based case control study No. of Sample : 479 CRC cases and 486 healthy controls Stage : TNM Stage I-IV | SNPs | Polymorhpism | - | LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] | Chromosome | 5 |
| Location | 5q31.3 |
| Start | 140011313 |
| End | 140013286 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1974 |
| OMIM ID | 158120 |
| HGNC ID | HGNC:1628 |
| Unigene ID | Hs.163867 |
| Ensembl ID | ENSG00000170458 |
| PharmGKB ID | PA26188 |
mRNA Information
| mRNA ID | NM_001174105.1 |
|---|---|
| Exon | join(1..150,510..633,722..1974) | mRNA Sequence | Download Select all |
| Length | 1540 |
Protein Information
| Protein ID | NP_001167576.1 |
|---|---|
| Protein Name | CD14 molecule |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 375 |
| Uniprot ID | Q92886 |
| Ensembl Protein ID | ENSP00000317580 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1604 | CD55 | 500 | NP_001108224.1 | in vitro | 11745332 |
| 4057 | LTF | 1028 | NP_002334.2 | in vitro | 11083760 |
| 7098 | TLR3 | 4324 | NP_003256.1 | in vitro;in vivo | 16473828 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Hematopoietic cell lineage | hsa04640 |
| Legionellosis | hsa05134 |
| MAPK signaling pathway | hsa04010 |
| NF-kappa B signaling pathway | hsa04064 |
| Pathogenic Escherichia coli infection | hsa05130 |
| Pertussis | hsa05133 |
| Phagosome | hsa04145 |
| Regulation of actin cytoskeleton | hsa04810 |
| Salmonella infection | hsa05132 |
| Toll-like receptor signaling pathway | hsa04620 |
| Transcriptional misregulation in cancer | hsa05202 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00116 | 104-309 | LRR_RI |
| cl23707 | 104-309 | LRR_RI superfamily |
| cd00116 | 188-349 | LRR_RI |
| pfam13855 | 276-331 | LRR_8 |
| COG4886 | 167-332 | LRR |
| PLN03210 | 116-292 | PLN03210 |
Ontology Information
| HPRD ID | 6980 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.