CoReCG

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General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CD151	977	CD151 molecule (Raph blood group)	11	SFA-1, PETA-3, TSPAN24, RAPH

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21913879	2011	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 179 CRC and 39 patients with hepatic liver metastasis. Stage : -	-	Down-regulation	-	CD151 expression is decreased in patients with metastatic CRC.

Gene Details

NC_000011.9 (832952..838840)
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Gene Type	protein coding
Gene Family	CD molecules, "Blood group antigens", "Tetraspanins"
Description	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Location	11p15.5
Start	832952
End	838840
Strand	+
Gene Sequence	>gi\|568815587:832952-838835 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly ATTCTCAGCGCTGGGAGCCGCCGCCCCCGCAGCTGCTGCCGCCGCCGCCAGGGCCCGGACTCGGACGCGT GGTAGGTGAGTGCGCGGCCACGACAGCTCGGCCGAGCGGGGCGAGCGGGGCGAGGGGGGCGAGGGGCGCG AGGGGGGCGAGGGGCGCGAGGGGGCCGAAGGCCCTGCGCGCCCCAGCCCCGGAGGCCCAGCCGCAGGCGC CGGGAGGTTCCGGGAGGCCGCACCCACCGCCTGGCCCAGCTCCCTCGCCTGCCCCAGCTCCCTCGCCTGC CCTTCCGCGGGAGGCGGACTCCGGGCGGGTTGGGGAGGCGCAGCGGGAAGGAGAGGCGCCTCCCGGGCCC TTGGACCGGCCTGACGGCCCCCTTCAGCCCAGGGGTCCCGGGACGCGCAGCCTGGACACCCTGCTCATTG TCCCTGGACACGGCAGTCTTCCCTCCGCCCGCAGCAGCCCCCGCCCGCGTGCAAGTGGGCGCGCCATTGG CCGCGCCGGGCGGGGTCGGCGGCGGCGGTGACCTCATTGCAGTGCCCCGGGGACGCTTGGCAGGCGCGGA GTCCCAGGTCCCCCTGACTGGGGCTCCCCCTGATAGGGCGCGGGCCGCCCAGGGGCCTGGTGCAGGTCCC GGGGACTTGGGGAGGAACAGACAACTATTTCTGGAAGGCCCTTTCCCAGGGGGTCCAGAGGGACCAGGCA TTCCTGGGAAGAGGGGCCACTCCTCAGCGGGTCGCCTGTGTCCTCGCGGTGGAGGACGCATCTGTGCCCA GAACCAACTTCTCCAGAAAGCCTGGGACCTTACAGCCAGGCCAGGGGCAGGTCCTTGAGGGGCTCACACA TCCCCCCATCGGTGGCAGACGCACACCCCGCCCCCCGGTGGCAGACACATCCCCCCGCTGGTGGCAGGGT CTGCCTGTGCCACCCTTCCTGCGTGTATTTAGGCCCTGGCTCCTTCATGGAGGGTGAATATCCCCTCTCA GCTCAGTGGTAAGGTCTGTCCCCCTCCAGCTCCATTCCATGATGCCTCTTTCCCAGGCTGTAGCTGCCGC TGTTTGTGGGGGAAGGGCCAGTGATGGGTCTGGAGCGAAGGCCAAGAGTGGGGCACCTGGGGGAAGGTAT GAGGTCCCTCCCAGGATCAGACTGTCCCGAAATGTCGTCTGCCTTGGGAGGCCAAGGCGGGTGGAACATC TAAGGTCAGGAGTTCGAGACCAGCCTGGTCCACATGGTGAAACTCTGTCTGTACTAAAAATACAAACATT AGCTGGGCGTGGTGGTGGGTGCCTGTAATCCCAGTGACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAAC TCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTGGGTGACAGAGCGAAACT CCATCTCAAAAAAAGAAAAAAAGAAAAAAACAAAATGTCTTGTGCCTTGCCCCACCCTAGCCCAGACTAA AATACCGGGCTTGGCCACTCCTCTCTCTGCCTCCAGAATGAACCCGGCCCACTCTGGCCCTTGGGCCAGA CCTGTAACCTGTGACCTGACATGTCCTTGCCCCTCTAGCCTAGAGTCCTGGGGAGCTTCTGTCCACCTGT CCTGCAGAGGAGTCGTTTCCAGCCCGGCTGGTGAGTGCTGGCCAGGGTGGGGCAGAGCAGGCGGGGCGGC GAAAGTCCAGACCTGGCTGTGCTGTCTGGAAACGTGGCCCAGGGCGCTCAGCTGCTGTCTGCACCCCACG CCCTCCCTGGCTTCCCCATGCTCACAGCTTGCCCACTGCTGCAGGTCGGGCGGGCACGGGGCATCTGGGG AGGGGCATAGCCTGTCTGTGCTGCCCCCTCAGGTTGGTGTGGGTCGCCTGTCCAGGAAAAACCCTCCCAG TCTGCCAGGCTCCACCTGCCTCCACGCTCCATTCTCCCCACCCCGGCCAGGATGAAGGAAGGGCTGCCCT TTAACAGACCGTAAACAGGCCTGGAGAGCTTAGGAAGGGGCTGAGCTGGGGCCTGTCTGAGCCCCTACCC CTCTGCTGTCTGAGTGGCCTCCTCCGCCCTTACTGCAGGCCCATAGGCTCCTGCCAGCCTGTGACGTGCG GCCCCGGGAATGCCGTGGGGAGCGGGCAGGCTGGCATGAGCTCACCGGAGGTACCCGCTAGGGCTTCCTC CCCCGGCCGCTAGCAGGGGTGAGTCAGCAGTGATGGCGGGAGGTCCTCCATGACCCCTGTCCTGTCTGTG GGCACCAGGGGTCTGTCCTGGCTGTCAGGGCTCCTGAGTCGCTAGGAAGTGACACGTCCTGTTCCCACAG GGGCTCATTCACAGGCCTCCCAGGACAGTGGCTGGCTCTGCCCCGACTTCTGGGCTGGCTTGGGTATCTG TGTCCCCTCTTTTTTTTCTTTTTTATTGAGATGGAGTCTCACTGTCGCCCAGCCTGGAGTGCAGTGGCAC CATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCT GGGACCACAGGCGCCCACCATCACGCCCAGTTAATTTTTGTATATTTTTGATGGAGATGGGGTTTCACCA CAATGGCCAGGCTGGTTGTGAACTCCCGACCTCAAGTGATTGCACCTGCCTTGGCCTCCCAAAGTGCTGG CATTATAGGCATGAGACACCGCACCTGGACTCCTTTCCTCTACTTTCTTTGGGTTAATTTGCTAGTCTCT TTTTATTATTTATTTATTTATTTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACC ATCTCGGCTCACTGCAAGCTTCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTG GGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTCTAGTACAGACGGGGTTTCACCGTG TTAGCCAGGATGGTCTTGATCTCCTGACCTTGTGATCTGCCTGCCTTGGCCCCCCAAAGTGCTGGGATTA CAGGCGTGAGCCACCGCGCCTGGCCCTGTGTCCCCTCCTATCCGTCTCCCAGTCAGGGGCCCGGTGCTGT GGCCCCGCTGACCCCTCCCCTGCCTCCTCAGCCCCAGGATGGGTGAGTTCAACGAGAAGAAGACAACATG TGGCACCGTTTGCCTCAAGTACCTGCTGTTTACCTACAATTGCTGCTTCTGGGTGAGGAGGGGTCGCCTT GCCCCCACCCCCACCCCCACCCCTCCCGGGCCACCATCAGACCTGGGCAGATGCGATGACCTTTGTGTAC TGCTTGTAGCTGGCTGGCCTGGCTGTCATGGCAGTGGGCATCTGGACGCTGGCCCTCAAGAGTGACTACA TCAGCCTGCTGGCCTCAGGCACCTACCTGGCCACAGCCTACATCCTGGTGGTGGCGGGCACTGTCGTCAT GGTGACTGGGGTCTTGGGCTGCTGCGCCACCTTCAAGGAGCGTCGGAACCTGCTGCGCCTGGTCAGGAGG GCGCAGGGCCACGGGGTGGGGGTGGTGCAGATGGGCCCAAGGAGGTTGTCGCTGCAGGCTTTGAACCTGT GCCTTGCTGTGCTCACCTGGGGGGGGGGTCACGGTCCTTCCACACCTGCCTAGTCCTGTGGGTCCCCACG TTCCTGCTGGACCAGCTGAGGGAAGACACCAGCTCCGCAAGAAAGCTTCAGGGAGGGTGGCCGCCCCTCA GCCCCCACCTGGAGCCTGGGGAGCCGGGGTGGGGACTCTGCTCTGAGGTGCACTAGGTCTAGGCACTAGG CCTCAGAACAAGGGTGCCCTTGTGCTGCCCCCCCCAGTACTTCATCCTGCTCCTCATCATCTTTCTGCTG GAGATCATCGCTGGTATCCTCGCCTACGCCTACTACCAGCAGGTGAGGGGCCTGGGCAGGCCATTCAGAG ACACAGACATGCACAGGCGGGGCGGACACACACACATGCACACGCGTGGCTAGCCCCAACCCCCACCCCC ATGGTCCCAGAGCTAACCAATGTGCCACTGGGCCCTGGAGATGGGGTCTAGGTCTCTGCAGGGGCACATG GGGTCAGGCAGGTGTCCAGGGGATCCAGAAGCTCTCTCTGCCTCTGCCGCACTTCATTGTCACCCTGGTG ACGGTCCTGGCACCACCCAACCTCCCCTCATGCCGAGGTGTGACCTCAGCCCTTCCCTGTGGCTCTGAGC TGGGCCCCGGGCCTCCCCACCGGCCATCCTGGGGCTCTGCCAGCCCCACCTTGGAAGGTCTTAGACTGAG GCTGAAGTTTCCTGCACCCCAACCCCAGCTGAACACGGAGCTCAAGGAGAACCTGAAGGACACCATGACC AAGCGCTACCACCAGCCGGGCCATGAGGCTGTGACCAGCGCTGTGGACCAGCTGCAGCAGGAGGTGGGTG GGTGGTGCTGGGAGGGCGCGTGCATCCCCAGGGCCTCCCTGGACCTCTGCAGGAGCCTCTGGCCCCAGGT CTCAACCCCAGCCTTGTTCTTGATGCAGTTCCACTGCTGTGGCAGCAACAACTCACAGGACTGGCGAGAC AGTGAGTGGATCCGCTCACAGGAGGCCGGTGGCCGTGTGGTCCCAGACAGCTGCTGCAAGACGGTGGTGG CTCTTTGTGGGCAGCGAGACCATGCCTCCAACATCTACAAGGTGGAGGTGGGTGTGCAGCGGGATCATGC CTCCAGTGTCTACGAGGTGGTGGGGGGGCACCCCAGTGACTGGCTGTGGGCAGTGGGACACGCCTCCAAT ATCTACCAGGAGGTGGGGGGTCACCCCAGTGGCCGGATGTGGGCAGTGAGACCACACCTCCAATATCTAC GAGGAAGTGGGTGGGCAGCCCAGTGGCTGGCTGAGCTGTTGGTGGCCTGGCTGCCTAGGTGCTAGGGGTG GGTTTGGCCACACCCTGGAGGCTGGAGGCAGTAGGGGCCAGTGGGAGGTGCCCCCTGGGCCCGCCTTCAA CACCCATCCGCGCCCCGCAGGGCGGCTGCATCACCAAGTTGGAGACCTTCATCCAGGAGCACCTGAGGGT CATTGGGGCTGTGGGGATCGGCATTGCCTGTGTGCAGGTGAGGGCACATGGGGGTGGCGGTCATCTTGTT GGGGACACGGGGCAGGGCGGTGGCTGGTGGCCCCATGACGTCTGCTTACGCCCACCCGGCTCTGCACACA GGTCTTTGGCATGATCTTCACGTGCTGCCTGTACAGGAGTCTCAAGCTGGAGCACTACTGACCCTGCCTT GGGCCTTGCTGCTGCTGCACCCAACTACTGAGCTGAGACCACTGAGTACCAGGGGCTGGGCTCCCTGATG ACACCCACCCTGTGCCATCACCATAACCTCTGGGGACCCCAACCTCAGAGGCAGCTTCAAGTGCCTTTTG CTGCGCACCAATGCCCAGCAGGGGAGGTGAGGGGGGCTGGCGGGGCGAAGTTTGGGGGGTGTTTTGTGGG GCTCCCCAGACACACTCTCTGCCTGGTGGTCAGATGCAGGTTGGAAGGGGCCTTGCTGAGTGGCGCAAGG CCGAGCGTTCCCAGCAGGGGGAGAAACCCTTCACACCCCAGGCCCTTCAGGAACTGGGGCCTTGCCTTGC AGCCACATGGCCCCATCCCAGTTGGGGAAGCCAGGTGAGCTCTGACCCTTGGGCCTGGGCCTCTGCCCCT CCCAACCCAGCCCTCGTCTCCCTCGACAGCGCCCCTGCTGTCTTCCCCACCGCAGTCACCACCACCCGAA ATGCCACGTGGTCACTGTGCACTGCCCTGTTCATGTGCCTCTGCGGGGCAGGGCCTTCCTGGTTTTGTTC ACTGCTGTACCCAGATGCCTACAACCATCCCTGCCACATACAGGTGCTCAATAAACACTTGTAGAGCAGA TGGA Download Select all
Length	5889
OMIM ID	602243
HGNC ID	HGNC:1630
Unigene ID	Hs.654379
Ensembl ID	ENSG00000177697
PharmGKB ID	PA26189

mRNA Information

mRNA ID	NM_004357.4
Exon	join(1..75,1579..1640,3112..3202,3300..3491,3818..3892, 4299..4403,4509..4667,4991..5077,5182..5884)
mRNA Sequence	Download Select all
Length	1574

CDS Information

Location	145..906
CDS Sequence	Download Select all
CCDS ID	CCDS7719.1

Protein Information

Protein ID	NP_004348.2
Protein Name	CD151 molecule (Raph blood group)
Molecular Wt. (Da)	28164
Protein Sequence	>lcl\|NM_004357.4_prot_NP_004348.2_1 [gene=CD151] [protein=CD151 antigen] [protein_id=NP_004348.2] [location=145..906] MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILVVAGTV VMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHE AVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCIT KLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY Download Select all
Length	253
Uniprot ID	Q13952
Ensembl Protein ID	ENSP00000312617

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Palmitoylation	11
C	Palmitoylation	15
C	Palmitoylation	242
C	Palmitoylation	243
C	Palmitoylation	11
C	Palmitoylation	15
C	Palmitoylation	242
C	Palmitoylation	243

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
3675	ITGA3	5431	NP_005492.1	in vivo	14676841
3688	ITGB1	628	NP_391987.1	in vivo	14676841
5738	PTGFRN	3124	NP_065173.2	in vitro;in vivo	11278880

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd03155	112-220	CD151_like_LEL
cl02781	112-220	tetraspanin_LEL superfamily
cd03127	112-220	tetraspanin_LEL
cd03166	112-218	CD63_LEL
cd03165	112-220	NET-5_like_LEL
cd03156	110-219	uroplakin_I_like_LEL
cd03163	111-221	TM4SF8_like_LEL
cd03164	112-224	CD53_like_LEL
cd03161	112-216	TM4SF2_6_like_LEL
cd03162	112-190	peripherin_like_LEL
cd03154	108-220	TM4SF3_like_LEL
cd03160	112-220	CD37_CD82_like_LEL
cd03158	114-220	penumbra_like_LEL
cd03159	146-220	TM4SF9_like_LEL
cd03157	124-217	TM4SF12_like_LEL
pfam00335	15-248	Tetraspannin

Ontology Information

HPRD ID	1197
Molecular Class	Cell surface receptor
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Important Information

Mechanism Down-regulation
Biomarker -
Drug Target -
Biological Process Cell communication