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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21258883 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : 109 CRC and 109 healthy controls Stage : - | PCR-SSP | Polymorhpism | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / C1-set domain containing" |
| Description | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | Chromosome | 1 |
| Location | 1q23.1 |
| Start | 158147828 |
| End | 158156217 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8390 |
| OMIM ID | 188410 |
| HGNC ID | HGNC:1637 |
| Unigene ID | Hs.1799 |
| Ensembl ID | ENSG00000158473 |
| PharmGKB ID | PA26196 |
mRNA Information
| mRNA ID | XM_011510125.1 |
|---|---|
| Exon | join(1..31,2782..3125,3418..3684,3995..4273,4841..5119, 5899..5998,6092..6859) | mRNA Sequence | Download Select all |
| Length | 2068 |
Protein Information
| Protein ID | XP_011508427.1 |
|---|---|
| Protein Name | CD1d molecule |
| Molecular Wt. (Da) | 37586 |
| Protein Sequence | Download Select all |
| Length | 335 |
| Uniprot ID | P51955 |
| Ensembl Protein ID | ENSP00000355965 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 60 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 567 | B2M | 189 | NP_004039.1 | in vivo | 1 125 730 710 221 650 |
| 811 | CALR | 169 | NP_004334.1 | in vivo | 12239218 |
| 821 | CANX | 252 | NP_001737.1 | in vivo | 12239218 |
| 972 | CD74 | 825 | NP_001020330.1 | in vivo | 11754812 |
| 5788 | PTPRC | 1050 | NP_002829.2 | in vivo | 10473580 |
| 6957 | TRB@ | 1739 | CAA45056.1 | in vivo | 12133957 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Hematopoietic cell lineage | hsa04640 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07698 | 203-295 | IgC_MHC_I_alpha3 |
| cl11960 | 203-295 | Ig superfamily |
| smart00407 | 222-286 | IGc1 |
| pfam07654 | 210-287 | C1-set |
| cd00098 | 222-295 | IgC |
| cd05766 | 221-287 | IgC_MHC_II_beta |
| cd05770 | 222-295 | IgC_beta2m |
| cd05767 | 222-295 | IgC_MHC_II_alpha |
| cd05768 | 222-286 | IgC_CH4 |
| cd05772 | 202-287 | IgC_SIRP |
| cd07699 | 222-287 | IgC_L |
| cd05771 | 222-287 | IgC_Tapasin_R |
| pfam00129 | 114-199 | MHC_I |
| cl08246 | 114-199 | MHC_I superfamily |
| cd05761 | 222-290 | Ig2_Necl-1-4_like |
Ontology Information
| HPRD ID | 3430 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.