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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CD68 | 968 | CD68 molecule | 17 | SCARD1, macrosialin, GP110, DKFZp686M18236, LAMP4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23868006 | 2013 | Cell line : - Source : Institut Gustave Roussy, Villejuif, France. Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Tissue microarray,Immunohistochemistry | Down-regulation | - | Tumour CD57+ and CD68+ TIC density assessment independently predicts survival in patients with stage II-III CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17p13 |
| Start | 7482805 |
| End | 7485429 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2625 |
| OMIM ID | 153634 |
| HGNC ID | HGNC:1693 |
| Unigene ID | Hs.647419 |
| Ensembl ID | ENSG00000129226 |
| PharmGKB ID | PA26232 |
mRNA Information
| mRNA ID | NM_001251.2 |
|---|---|
| Exon | join(1..240,324..841,980..1099,1225..1297,1410..1580, 1892..2625) | mRNA Sequence | Download Select all |
| Length | 1872 |
Protein Information
| Protein ID | NP_001242.2 |
|---|---|
| Protein Name | CD68 molecule |
| Molecular Wt. (Da) | 35367 |
| Protein Sequence | Download Select all |
| Length | 354 |
| Uniprot ID | Q00653 |
| Ensembl Protein ID | ENSP00000189444 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Lysosome | hsa04142 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 5633 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Transcription (GO:0006350) |
Drug Information
No matching records could be found.