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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25497975 | 2015 | Cell line : - Source : First Affiliated Hospital of Soochow University . Sample Type : CRC tumor and normal tissue No. of Sample : 715 health controls, 382 CRC Stage : - | SNP genotyping,Luciferase reporter assays | Polymorhpism | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / C2-set domain containing" |
| Description | The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] | Chromosome | 3 |
| Location | 3q13.3-q21 |
| Start | 119243140 |
| End | 119278481 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 35342 |
| OMIM ID | 112203 |
| HGNC ID | HGNC:1700 |
| Unigene ID | Hs.838 |
| Ensembl ID | ENSG00000121594 |
| PharmGKB ID | PA26239 |
mRNA Information
| mRNA ID | NM_016589.3 |
|---|---|
| Exon | complement(<35354..>35687) | mRNA Sequence | Download Select all |
| Length | 1596 |
Protein Information
| Protein ID | NP_057673.2 |
|---|---|
| Protein Name | CD80 molecule |
| Molecular Wt. (Da) | 29478 |
| Protein Sequence | Download Select all |
| Length | 285 |
| Uniprot ID | P35240 |
| Ensembl Protein ID | ENSP00000335652 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Graft-versus-host disease | hsa05332 |
| Intestinal immune network for IgA production | hsa04672 |
| Rheumatoid arthritis | hsa05323 |
| Systemic lupus erythematosus | hsa05322 |
| Toll-like receptor signaling pathway | hsa04620 |
| Type I diabetes mellitus | hsa04940 |
| Viral myocarditis | hsa05416 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00098 | 154-232 | IgC |
| cl11960 | 154-232 | Ig superfamily |
| pfam08205 | 143-227 | C2-set_2 |
| cd05713 | 85-138 | Ig_MOG_like |
| cl11960 | 85-138 | Ig superfamily |
| cd07705 | 162-209 | Ig2_Necl-1 |
| cd05716 | 38-139 | Ig_pIgR |
| smart00406 | 46-118 | IGv |
| cd00099 | 38-118 | IgV |
| cd00096 | 46-118 | Ig |
| cd05884 | 159-206 | Ig2_Necl-3 |
| cd05761 | 162-209 | Ig2_Necl-1-4_like |
| cd05724 | 162-186 | Ig2_Robo |
| smart00410 | 37-138 | IG_like |
| smart00409 | 37-138 | IG |
Ontology Information
| HPRD ID | 2732 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P33681 | DB01281 | Abatacept | BiotechDrug |
| P33681 | DB06681 | Belatacept | BiotechDrug |