CoReCG

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General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CDC20	991	cell division cycle 20	1	p55CDC, CDC20A

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23758705	2013	Cell line : - Source : Sun Yat-sen University Cancer Center Sample Type : CRC tumor and Normal tissue No. of Sample : 244 Stage : -	Western blotting, Immunohistochemistry	Up-regulation	-	CDC20 may serve as a potential prognostic biomarker of human colorectal cancer. CDC20 was overexpressed in colon cancer cell lines/primary cancer tissues compared with normal colon epithelial cell lines/adjacent noncancerous tissue samples. Interestingly, CDC20 expression was further increased in metastatic liver tissues.

Gene Details

Chromosome 1 - NC_000001.11 (43358955..43363203)
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Gene Type	protein coding
Gene Family	WD repeat domain containing
Description	CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
Chromosome	1
Location	1p34.1
Start	43358955
End	43363203
Strand	+
Gene Sequence	>gi\|568815597:43358955-43363203 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly GAGGCGTAAGCCAGGCGTGTTAAAGCCGGTCGGAACTGCTCCGGAGGGCACGGTGAGAGGTGGTGGGGCT GAGCCGAGGTGGGGCCGTGGCCAGGGGGAGGGGGTGCTAGGCCGGAAGGGGCTGCAGCCGAGGGTGGCCC TGATTTTGTGGCCGGCCAGGAGCGAAGGGGTCCCTTTCTGTCCCCTGAGCACCGTCGCCTCCTTTCCTCC AGGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTGCGGGCGCTCCCATGGCACAGTTCGCGTTCG AGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGCG CAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGC AGGACTCCGGGCCGAACTCCTGGTCAGTGAGGTGCCAAAGGAACTGAGTGAGAGCAGCCTTCATACTTTC TCCCTGGGGAGCCTGGTCAGACTGTCTTCTCTTTCTCCGCCCCAGGCAAATCCAGTTCCAAGGTTCAGAC CACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGC TTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGTATGTGTCCCAGAGG GGCTTAAGGCACGGGACCTGACTGTTCTTTGGATAATACCATCTTGCTCCTTCACTACCCTTTATGCCAG GAACATCAGAAAGCCTGGGCTTTGAACCTGAACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCA GTGGAAAACCACAAAATGCGCCAGAGGGTAAGACCCGAAGTTCCTGGTTCCTGGAGGGAGGTGTCAGTTC ATCTCCAGGGCTGAGCACAGATATCTGTCTCCTCTTCCTATCTAAGATTGAGGGCAAGGGAGGTGTTGAT TTTCCCAGCGTCTAGACTCACTCCGTTGCCACAGGTTATCAGAACAGACTGAAAGTACTCTACAGCCAAA AGGCCACTCCTGGCTCCAGCCGGAAGACCTGCCGTTACATTCCTTCCCTGCCAGACCGTATCCTGGATGC GCCTGAAATCCGAAATGACTATTGTAAGTGCATCCTTATCCTCGCCTCATGCATGGAGAAAGAGGGCCTG GGACCACACAAACAAGGAAGCTCATGCTCTTCTCTCCACCTCTGACAGACCTGAACCTTGTGGATTGGAG TTCTGGGAATGTACTGGCCGTGGCACTGGACAACAGTGTGTACCTGTGGAGTGCAAGCTCTGGTGACATC CTGCAGCTTTTGCAAATGGAGCAGCCTGGGGAATATATATCCTCTGTGGCCTGGATCAAAGAGGGCAACT ACTTGGCTGTGGGCACCAGCAGTGCTGAGGTGCAGGTGAGACGTGTCCAGTGCTGTCATTCTCACCAGTC CCAATGGGCTTGCACAGCTGGAGGATATTAATGCCAAGTCCCAATCTCTGATCCTAGTGGGCTTCTCTCT CTAGCTATGGGATGTGCAGCAGCAGAAACGGCTTCGAAATATGACCAGTCACTCTGCCCGAGTGGGCTCC CTAAGCTGGAACAGCTATATCCTGTCCAGGTCAGTGGTTTTTGTTGGTCTATGGTAGTCTGATATTTGCC CACCCTCCCCTTGACTGTACACCCCTGAACTGAACCAGCTCTGGCTTGCTTGCATTTGGTGCTGCCACAG AACCTGATTCCCTTCTTTCCTCCTCCAGTGGTTCACGTTCTGGCCACATCCACCACCATGATGTTCGGGT AGCAGAACACCATGTGGCCACACTGAGTGGCCACAGCCAGGAAGTGTGTGGGCTGCGCTGGGCCCCAGAT GGACGACATTTGGCCAGTGGTGGTAATGATAACTTGGTCAATGTGTGGCCTAGTGCTCCTGGAGAGGGTG GCTGGGTTCCTCTGCAGACATTCACCCAGCATCAAGGGGCTGTCAAGGTGAGTAGGGTTGGGCTGAAGCC TCTGCAGACCCTCACCTATAATCTGGGGACTGTTAAGGGGAGAAGGGATGGTAGGATTGGACTGGGTTAA TCTGTGACCCCTAGAGCTCCTTGTCTGGCTCTAGTACCTGCTGACCCCACCTTTATTCCATCTAGGCCGT AGCATGGTGTCCCTGGCAGTCCAATGTCCTGGCAACAGGAGGGGGCACCAGTGATCGACACATTCGCATC TGGAATGTGTGCTCTGGGGCCTGTCTGAGTGCCGTGGATGCCCATTCCCAGGTAATCTTTTGCCTGTTCC TGCCTCTCCCACATGCATTCTTACCGGGCAACTACATTCACTCCAATGGCTTCACCAACTCTATGCCCTG GTGATTCCCAAACTTCTAACTCAGCTCTCACTCATGAGCTTCATTTCCAACAGTCTGTGGCTATCTCCAA TCCTATGTCCTATAGGCACCACCACCTTGATCTGTCCCAAATTAACCTTGTCACTTCCCCTTGCCTCCCT GAAATGTGTTCCTTCCTGTCTCACATTGCTTTGGAATGGCAGAACCTGCTCAGAAATCTGAGAAACCTCC TAGAATTTTTCATCCTCCTCACCAGGATCTATCAGTTTTACCTCAAAATATCATTGACATCTGTCCCCTC CCCTCAGCCTCATCCTTCCAAGTGGAGGCCCACTACAATGGCTTCCTCACTGGTGTCAAGCATTCTTTGT TATCTCCTGCAATGCATCCTCCATGCTGTGGTCTGTTATACTGTACTGTCCTTAAACCTGTGATGGCTTC CCATCACTTATGGCATATAATCCAAATCCATTAGAAAGATACTTGAGGCTCTCTCCTTCCACTCCCCCCA CATTCAGCCTTCACTGTAGATATGGACTCTAGAGCCAGATGGCCCAAGTTAAAATTCTGGCTCTGTCATC TACTAAACTTGAATGTGACCTTTGGCAACCTATTGAACTTCCTTCTGATTGATTCCTCATCTATCCAATG GATAATACAGATGCTCCCTGATTTAAGTCCCAGTAAACCCACTGTAAAGGTAAAAAATGGTTACATCAGC GAGTGTCTATAATTTGCCTCTCAAGGAACTTTTGTATGGACTATGATCATTCAACTCTGAGTCTGGAGCA TGTGGCAGGGTGCCTAACACTAGAATGGGCTCAGTTCTGATTTAAGTAGCCTTGGCTATATGTCATGCCC ACACCAGCTCCTCTCCACAGGTGTGCTCCATCCTCTGGTCTCCCCATTACAAGGAGCTCATCTCAGGCCA TGGCTTTGCACAGAACCAGCTAGTTATTTGGAAGTACCCAACCATGGCCAAGGTGGCTGAACTCAAAGGT AAGTGGCTAGGTGAAAAGCCGGACATAAAAGGCCACATAATGTATGACTGAAATGTCCAGAATAAGCAAA TCCAGAGAAAAAACACATTAATGGTTGCCAGGGGCTGAGAGAGGGTAATGGGAAATGTTGAAAATGTCTT AGAATTAGTTTTAACAGTTGTACAATTTTGTGAATATACTAAAAATCACTAAACTGTACACTTTAAAAGG ATGCATTTTATGGTGTGTGAATTATATCTCAGTAACACCATTGAAAAAAAAGGGAGGAGGCCAGGCACGG TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCATGAGGTCAGGAGATAGAGA CAATCCTGGCTAACATGGTGAAGCCCTGTCTCTACTAAAAAACACAAAAAATTAGCCAGGCGTGGTGGCA AGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAAAATGGCATGAACCCAGGAGGCGGAGCTTG CAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGTCTCAAAAAAAACAAAAAGG TAGGTGGGTGGCCCAGTGCCTCCTTTATGGCTATGGCTGCATCAGCATTCGTATGTACTGTTCTCATTTG CTCCAGGTCACACATCCCGGGTCCTGAGTCTGACCATGAGCCCAGATGGGGCCACAGTGGCATCCGCAGC AGCAGATGAGACCCTGAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGCGGCGGCGGGAGCGGGAGAAG GCCAGTGCAGCCAAAAGCAGCCTCATCCACCAAGGCATCCGCTGAAGACCAACCCATCACCTCAGTTGTT TTTTATTTTTCTAATAAAGTCATGTCTCCCTTCATGTTTTTTTTTTAAA Download Select all
Length	4249
OMIM ID	603618
HGNC ID	HGNC:1723
Unigene ID	Hs.524947
Ensembl ID	ENSG00000117399
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001255.2
Exon	join(1..52,213..442,536..684,771..867,1015..1143, 1239..1435,1545..1639,1779..2007,2166..2291,3241..3358, 3997..4249)
mRNA Sequence	>991 GAGGCGTAAGCCAGGCGTGTTAAAGCCGGTCGGAACTGCTCCGGAGGGCACGGGCTCCGTAGGC ACCAACTGCAAGGACCCCTCCCCCTGCGGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGAC CTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGCGCA AAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGC CGGCAGGACTCCGGGCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAA CCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCC TGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAACATCAGAAAGCCTG GGCTTTGAACCTGAACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCA CAAAATGCGCCAGAGGGTTATCAGAACAGACTGAAAGTACTCTACAGCCAAAAGGCCACTCCTG GCTCCAGCCGGAAGACCTGCCGTTACATTCCTTCCCTGCCAGACCGTATCCTGGATGCGCCTGA AATCCGAAATGACTATTACCTGAACCTTGTGGATTGGAGTTCTGGGAATGTACTGGCCGTGGCA CTGGACAACAGTGTGTACCTGTGGAGTGCAAGCTCTGGTGACATCCTGCAGCTTTTGCAAATGG AGCAGCCTGGGGAATATATATCCTCTGTGGCCTGGATCAAAGAGGGCAACTACTTGGCTGTGGG CACCAGCAGTGCTGAGGTGCAGCTATGGGATGTGCAGCAGCAGAAACGGCTTCGAAATATGACC AGTCACTCTGCCCGAGTGGGCTCCCTAAGCTGGAACAGCTATATCCTGTCCAGTGGTTCACGTT CTGGCCACATCCACCACCATGATGTTCGGGTAGCAGAACACCATGTGGCCACACTGAGTGGCCA CAGCCAGGAAGTGTGTGGGCTGCGCTGGGCCCCAGATGGACGACATTTGGCCAGTGGTGGTAAT GATAACTTGGTCAATGTGTGGCCTAGTGCTCCTGGAGAGGGTGGCTGGGTTCCTCTGCAGACAT TCACCCAGCATCAAGGGGCTGTCAAGGCCGTAGCATGGTGTCCCTGGCAGTCCAATGTCCTGGC AACAGGAGGGGGCACCAGTGATCGACACATTCGCATCTGGAATGTGTGCTCTGGGGCCTGTCTG AGTGCCGTGGATGCCCATTCCCAGGTGTGCTCCATCCTCTGGTCTCCCCATTACAAGGAGCTCA TCTCAGGCCATGGCTTTGCACAGAACCAGCTAGTTATTTGGAAGTACCCAACCATGGCCAAGGT GGCTGAACTCAAAGGTCACACATCCCGGGTCCTGAGTCTGACCATGAGCCCAGATGGGGCCACA GTGGCATCCGCAGCAGCAGATGAGACCCTGAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGC GGCGGCGGGAGCGGGAGAAGGCCAGTGCAGCCAAAAGCAGCCTCATCCACCAAGGCATCCGCTG AAGACCAACCCATCACCTCAGTTGTTTTTTATTTTTCTAATAAAGTCATGTCTCCCTTCATGTT TTTTTTTTAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	1697

CDS Information

Location	join(262..442,536..684,771..867,1015..1143,1239..1435, 1545..1639,1779..2007,2166..2291,3241..3358,3997..4175)
CDS Sequence	>lcl\|NM_001255.2_cds_NP_001246.2_1 [gene=CDC20] [protein=cell division cycle protein 20 homolog] [protein_id=NP_001246.2] [location=102..1601] ATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCAC CCCCTGCGCGCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAA CCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACT CCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCC TCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAACATCAGAAAGCCTGGGC TTTGAACCTGAACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCG CCAGAGGGTTATCAGAACAGACTGAAAGTACTCTACAGCCAAAAGGCCACTCCTGGCTCCAGCCGGAAGA CCTGCCGTTACATTCCTTCCCTGCCAGACCGTATCCTGGATGCGCCTGAAATCCGAAATGACTATTACCT GAACCTTGTGGATTGGAGTTCTGGGAATGTACTGGCCGTGGCACTGGACAACAGTGTGTACCTGTGGAGT GCAAGCTCTGGTGACATCCTGCAGCTTTTGCAAATGGAGCAGCCTGGGGAATATATATCCTCTGTGGCCT GGATCAAAGAGGGCAACTACTTGGCTGTGGGCACCAGCAGTGCTGAGGTGCAGCTATGGGATGTGCAGCA GCAGAAACGGCTTCGAAATATGACCAGTCACTCTGCCCGAGTGGGCTCCCTAAGCTGGAACAGCTATATC CTGTCCAGTGGTTCACGTTCTGGCCACATCCACCACCATGATGTTCGGGTAGCAGAACACCATGTGGCCA CACTGAGTGGCCACAGCCAGGAAGTGTGTGGGCTGCGCTGGGCCCCAGATGGACGACATTTGGCCAGTGG TGGTAATGATAACTTGGTCAATGTGTGGCCTAGTGCTCCTGGAGAGGGTGGCTGGGTTCCTCTGCAGACA TTCACCCAGCATCAAGGGGCTGTCAAGGCCGTAGCATGGTGTCCCTGGCAGTCCAATGTCCTGGCAACAG GAGGGGGCACCAGTGATCGACACATTCGCATCTGGAATGTGTGCTCTGGGGCCTGTCTGAGTGCCGTGGA TGCCCATTCCCAGGTGTGCTCCATCCTCTGGTCTCCCCATTACAAGGAGCTCATCTCAGGCCATGGCTTT GCACAGAACCAGCTAGTTATTTGGAAGTACCCAACCATGGCCAAGGTGGCTGAACTCAAAGGTCACACAT CCCGGGTCCTGAGTCTGACCATGAGCCCAGATGGGGCCACAGTGGCATCCGCAGCAGCAGATGAGACCCT GAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGCGGCGGCGGGAGCGGGAGAAGGCCAGTGCAGCCAAA AGCAGCCTCATCCACCAAGGCATCCGCTGA Download Select all
CCDS ID	CCDS484.1

Protein Information

Protein ID	NP_001246.2
Protein Name	cell division cycle 20
Molecular Wt. (Da)	54592
Protein Sequence	>991 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSS SKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEA KILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ QQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI WNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLS LTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR Download Select all
Length	499
Uniprot ID	P49682
Ensembl Protein ID	ENSP00000362795

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	41
S	Phosphorylation	72
S	Phosphorylation	92
S	Phosphorylation	153
T	Phosphorylation	157
S	Phosphorylation	161
S	Phosphorylation	63
S	Phosphorylation	64
T	Phosphorylation	70
Y	Phosphorylation	79

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
701	BUB1B	4176	NP_001202.4	in vitro;in vivo;yeast 2-hybrid	11 030 144 115 356 100 000 000 000 000 000
890	CCNA2	453	NP_001228.1	in vivo;yeast 2-hybrid	10679238
996	CDC27	304	NP_001107563.1	in vitro;in vivo	973 671 214 561 775 000 000 000 000 000
4085	MAD2L1	3274	NP_002349.1	in vitro;in vivo;yeast 2-hybrid	9 628 895 145 617 750 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000
6790	AURKA	4066	NP_003591.2	in vitro	10377410
6950	TCP1	1748	NP_110379.2	in vivo	12887895
7046	TGFBR1	1822	NP_004603.1	in vivo	15761153
8881	CDC16	4587	NP_003894.3	in vitro;in vivo	962 889 512 196 507
64682	ANAPC1	9769	NP_073153.1	in vitro;in vivo	11438673

Pathway Information

Pathway Name	Pathway ID
Cell cycle	hsa04110
HTLV-I infection	hsa05166
Oocyte meiosis	hsa04114
Ubiquitin mediated proteolysis	hsa04120
Viral carcinogenesis	hsa05203

Structure Information

PDB ID	4GGA
Resolution	2.04
Method	X-RAY DIFFRACTION
Chains	A
Molecule	Cell division cycle protein 20 homolog
Model	View

Domain Information

ID	Location	Description
cd00200	190-471	WD40
cl02567	190-471	WD40 superfamily
cd00200	301-470	WD40
pfam00400	301-336	WD40
smart00320	302-336	WD40
pfam00400	435-470	WD40
smart00320	432-470	WD40
pfam00400	345-386	WD40
smart00320	345-386	WD40
cd00200	436-482	WD40
COG2319	183-473	WD40
COG2319	157-470	WD40
PLN00181	229-418	PLN00181
PLN00181	294-470	PLN00181
PTZ00421	301-435	PTZ00421
COG2319	187-258	WD40

Ontology Information

HPRD ID	150
Molecular Class	Cell cycle control protein
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Signal transduction (GO:0007165); Regulation of cell cycle (GO:0000074)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Important Information

Mechanism Up-regulation
Biomarker -
Drug Target -
Biological Process Cell cycle