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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23884297 | 2013 | Cell line : SW480 cells Source : - Sample Type : - No. of Sample : - Stage : - | immunofluorescence staining, attachment assay, a wound healing assay, and a Matrigel migration assay | Up-regulation | - | Rho GTPase Cdc42 can greatly enhance colorectal cancer cell SW480 to spread, migrate, and invade, which may contribute to colorectal cancer metastasis. |
| 24817781 | 2014 | Cell line : HT 29, CaCO2 SW620 HCT-116 Source : Department of Surgery, Chung Shan Medical University Hospital. Sample Type : CRC tumor No. of Sample : 79 Stage : - | DNA Sequencing, Transfection,Cell Proliferation Assay, Wound-Healing Assay,Western Blotting,Boyden Chamber Migration Assay,real time RT-PCR | Up-regulation | - | Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels.Expression levels of miR-224 in CRC tissues were significantly lower. |
| 25379703 | 2014 | Cell line : HCT116 colorectal carcinoma cells Source : Flinders Tissue Bank Sample Type : - No. of Sample : 30 CRC samples and corresponding normal colorectal mucosa. Stage : - | Luciferase assay,real-time RT-PCR,Western blotting , cell proliferation assay, apoptosis assay | Up-regulation | - | miR-18a directly targets the 3'UTR of CDC42. In colorectal cancer samples and corresponding normal colorectal mucosa, miR-18a displayed lower overall expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] | Chromosome | 1 |
| Location | 1p36.1 |
| Start | 22379120 |
| End | 22419439 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40320 |
| OMIM ID | 116952 |
| HGNC ID | HGNC:1736 |
| Unigene ID | Hs.467637 |
| Ensembl ID | ENSG00000070831 |
| PharmGKB ID | PA26266 |
mRNA Information
| mRNA ID | NM_001039802.1 |
|---|---|
| Exon | join(1..116,21468..21593,25803..25957,29096..29168, 33813..33922,34043..34240,38802..40317) | mRNA Sequence | Download Select all |
| Length | 2308 |
Protein Information
| Protein ID | NP_001034891.1 |
|---|---|
| Protein Name | cell division cycle 42 |
| Molecular Wt. (Da) | 21128 |
| Protein Sequence | Download Select all |
| Length | 191 |
| Uniprot ID | P15531 |
| Ensembl Protein ID | ENSP00000013034 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Methylation | 188 |
| C | Prenylation | 188 |
| D | Proteolytic Cleavage | 118 |
| D | Proteolytic Cleavage | 121 |
| D | Proteolytic Cleavage | 118 |
| D | Proteolytic Cleavage | 121 |
| D | Proteolytic Cleavage | 118 |
| D | Proteolytic Cleavage | 121 |
| D | Proteolytic Cleavage | 118 |
| D | Proteolytic Cleavage | 121 |
| K | Acetylation | 135 |
| K | Acetylation | 135 |
| K | Acetylation | 135 |
| K | Acetylation | 144 |
| K | Acetylation | 144 |
| K | Acetylation | 144 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1937 | EEF1G | 11745 | NP_001395.1 | yeast 2-hybrid | 16169070 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro | 16293614 |
| 4649 | MYO9A | 5341 | NP_008832.2 | yeast 2-hybrid | 16169070 |
| 5147 | PDE6D | 4056 | NP_002592.1 | yeast 2-hybrid | 16169070 |
| 7157 | TP53 | 1859 | NP_000537.3 | yeast 2-hybrid | 16169070 |
| 7454 | WAS | 2314 | NP_000368.1 | in vitro;in vivo | 8 625 410 107 241 600 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 |
| 8874 | ARHGEF7 | 5688 | NP_001106983.1 | in vitro | 1 564 935 716 983 070 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 9459 | ARHGEF6 | 2226 | NP_004831.1 | in vitro | 15649357 |
| 10602 | CDC42EP3 | 9364 | NP_006440.2 | in vitro;yeast 2-hybrid | 10490598 |
| 11135 | CDC42EP1 | 7303 | NP_689449.1 | yeast 2-hybrid | 16189514 |
| 11161 | C14orf1 | 5201 | NP_009107.1 | yeast 2-hybrid | 16169070 |
| 23048 | FNBP1 | 10446 | NP_055848.1 | yeast 2-hybrid | 12421766 |
| 23263 | MCF2L | 14371 | NP_001106203.1 | in vitro | 118 890 371 200 698 000 000 000 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
| 56882 | CDC42SE1 | 16694 | NP_064624.1 | yeast 2-hybrid | 1 081 658 412 421 760 |
| 84612 | PARD6B | 18703 | NP_115910.1 | in vitro;in vivo | 146 761 911 126 025 000 000 000 |
| 197131 | UBR1 | 9342 | NP_777576.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Axon guidance | hsa04360 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Chemokine signaling pathway | hsa04062 |
| Endocytosis | hsa04144 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Focal adhesion | hsa04510 |
| GnRH signaling pathway | hsa04912 |
| Leukocyte transendothelial migration | hsa04670 |
| MAPK signaling pathway | hsa04010 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Pancreatic cancer | hsa05212 |
| Pathogenic Escherichia coli infection | hsa05130 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Renal cell carcinoma | hsa05211 |
| Salmonella infection | hsa05132 |
| Shigellosis | hsa05131 |
| T cell receptor signaling pathway | hsa04660 |
| Tight junction | hsa04530 |
| VEGF signaling pathway | hsa04370 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01874 | 3-177 | Cdc42 |
| cl21455 | 3-177 | P-loop_NTPase superfamily |
| smart00174 | 6-179 | RHO |
| cd00157 | 4-175 | Rho |
| cd01871 | 4-175 | Rac1_like |
| cd01875 | 1-191 | RhoG |
| cd04130 | 4-176 | Wrch_1 |
| cd04135 | 4-177 | Tc10 |
| cd04132 | 4-191 | Rho4_like |
| cd01870 | 5-177 | RhoA_like |
| cd04133 | 4-173 | Rop_like |
| cd04129 | 5-177 | Rho2 |
| cd04131 | 4-177 | Rnd |
| cd04134 | 5-189 | Rho3 |
| cd04172 | 2-177 | Rnd3_RhoE_Rho8 |
| cd04173 | 5-187 | Rnd2_Rho7 |
| cd04174 | 5-182 | Rnd1_Rho6 |
| cd00154 | 4-173 | Rab |
| cd01873 | 2-176 | RhoBTB |
| cd00876 | 5-173 | Ras |
| smart00175 | 4-171 | RAB |
| smart00173 | 5-169 | RAS |
| smart00010 | 5-169 | small_GTPase |
| cd04145 | 2-172 | M_R_Ras_like |
| cd04123 | 4-170 | Rab21 |
| cd00882 | 7-173 | Ras_like_GTPase |
| cd04139 | 5-169 | RalA_RalB |
| cd04138 | 5-169 | H_N_K_Ras_like |
| cd04144 | 5-191 | Ras2 |
| cd04137 | 5-190 | RheB |
| cd01863 | 4-174 | Rab18 |
| cd01862 | 5-178 | Rab7 |
| cd04111 | 7-161 | Rab39 |
| cd04106 | 4-150 | Rab23_like |
| cd04177 | 5-173 | RSR1 |
| cd01861 | 5-177 | Rab6 |
| cd04116 | 4-173 | Rab9 |
| cd01860 | 3-171 | Rab5_related |
| cd04136 | 5-173 | Rap_like |
| cd04176 | 5-173 | Rap2 |
| cd04110 | 5-153 | Rab35 |
| cd04175 | 5-169 | Rap1 |
| cd04141 | 5-169 | Rit_Rin_Ric |
| cd01869 | 5-175 | Rab1_Ypt1 |
| cd01893 | 4-179 | Miro1 |
| cd04127 | 4-161 | Rab27A |
| cd04115 | 2-162 | Rab33B_Rab33A |
| cd04119 | 4-170 | RJL |
| cd04143 | 7-169 | Rhes_like |
| cd01867 | 4-169 | Rab8_Rab10_Rab13_like |
| cd00877 | 4-127 | Ran |
| cd04118 | 4-169 | Rab24 |
| cd04117 | 5-169 | Rab15 |
| pfam08477 | 5-118 | Miro |
| cd04146 | 5-173 | RERG_RasL11_like |
| cd01865 | 5-173 | Rab3 |
| cd01868 | 5-122 | Rab11_like |
| cd04124 | 4-128 | RabL2 |
| cd04108 | 5-179 | Rab36_Rab34 |
| cd04101 | 5-171 | RabL4 |
| cd04114 | 5-171 | Rab30 |
| cd04128 | 4-169 | Spg1 |
| cd01864 | 5-174 | Rab19 |
| cd04112 | 5-161 | Rab26 |
| cd01866 | 5-169 | Rab2 |
| cd04147 | 5-119 | Ras_dva |
| cd04148 | 5-187 | RGK |
| cd04122 | 5-172 | Rab14 |
| cd04140 | 5-173 | ARHI_like |
| cd04113 | 5-172 | Rab4 |
| cd04107 | 5-173 | Rab32_Rab38 |
| cd09914 | 4-138 | RocCOR |
| cd04120 | 7-169 | Rab12 |
| cd04109 | 4-119 | Rab28 |
| cd04126 | 4-156 | Rab20 |
| cd04142 | 4-177 | RRP22 |
| cd04121 | 4-187 | Rab40 |
| cd01892 | 4-119 | Miro2 |
| cd04103 | 8-172 | Centaurin_gamma |
| pfam00025 | 2-170 | Arf |
| cd00878 | 5-170 | Arf_Arl |
| cd04152 | 2-187 | Arl4_Arl7 |
| pfam00071 | 5-178 | Ras |
| TIGR00231 | 3-157 | small_GTP |
| COG1100 | 1-183 | Gem1 |
| PTZ00132 | 3-121 | PTZ00132 |
| PTZ00369 | 1-191 | PTZ00369 |
| PLN03118 | 3-180 | PLN03118 |
| PLN03071 | 3-178 | PLN03071 |
| smart00176 | 9-181 | RAN |
| PLN03108 | 5-169 | PLN03108 |
| PLN03110 | 5-169 | PLN03110 |
| PTZ00099 | 26-152 | PTZ00099 |
Ontology Information
| HPRD ID | 1226 |
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.