Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH17 | 1015 | cadherin 17, LI cadherin (liver-intestine) | 8 | HPT-1, cadherin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23326130 | 2012 | Cell line : - Source : First Affiliated Hospital of Zhengzhou University were included in this study. Sample Type : CRC tumor No. of Sample : 93 Stage : TNM Stage I-IV | PCR-SSCP and sequencing | Polymorhpism | - | The SNPs of the CDH17 gene c.2216 A>C might be clinically important in the prognosis of colorectal carcinoma. |
| 23604127 | 2014 | Cell line : SW480, SW620, Caco2, RKO, SW48, Colo320, HT29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Co-immunoprecipitation,tissue microarrays,mass spectrometry analysis | Up-regulation | - | Data reveal a new function for CDH17, which is to regulate ?2?1 integrin signaling in cell adhesion and proliferation in colon cancer cells for liver metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] | Chromosome | 8 |
| Location | 8q22.1 |
| Start | 95139394 |
| End | 95229531 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 90138 |
| OMIM ID | 603017 |
| HGNC ID | HGNC:1756 |
| Unigene ID | Hs.591853 |
| Ensembl ID | ENSG00000079112 |
| PharmGKB ID | PA26290 |
mRNA Information
| mRNA ID | XM_011516790.1 |
|---|---|
| Exon | join(8718..8821,22599..22669,28019..28117,39583..39717, 40625..40763,43044..43202,43308..43507,46319..46450, 46757..46907,51328..51543,55142..55218,57142..57333, 65192..65436,68430..68560,86312..86428,86565..86678, 88964..90142) | mRNA Sequence | Download Select all |
| Length | 3461 |
Protein Information
| Protein ID | XP_011515092.1 |
|---|---|
| Protein Name | cadherin 17, LI cadherin (liver-intestine) |
| Molecular Wt. (Da) | 83324 |
| Protein Sequence | Download Select all |
| Length | 752 |
| Uniprot ID | P01303 |
| Ensembl Protein ID | ENSP00000242152 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 548 |
| S | Phosphorylation | 425 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 570-663 | Cadherin_repeat |
| cl15786 | 570-663 | CA_like superfamily |
| cd11304 | 131-235 | Cadherin_repeat |
| cl15786 | 131-235 | CA_like superfamily |
| cd11304 | 346-444 | Cadherin_repeat |
| cl15786 | 346-444 | CA_like superfamily |
| cd11304 | 33-122 | Cadherin_repeat |
| cl15786 | 33-122 | CA_like superfamily |
| cd11304 | 456-562 | Cadherin_repeat |
| cl15786 | 456-562 | CA_like superfamily |
| cd11304 | 245-336 | Cadherin_repeat |
| cl15786 | 245-336 | CA_like superfamily |
| smart00112 | 271-338 | CA |
| smart00112 | 58-124 | CA |
| pfam00028 | 571-640 | Cadherin |
| smart00112 | 592-665 | CA |
| pfam00028 | 131-235 | Cadherin |
| pfam00028 | 346-440 | Cadherin |
| pfam00028 | 35-116 | Cadherin |
| smart00112 | 149-235 | CA |
| smart00112 | 363-447 | CA |
| pfam00028 | 284-330 | Cadherin |
| smart00112 | 473-564 | CA |
| pfam00028 | 458-535 | Cadherin |
| cd00031 | 268-336 | CA_like |
| cd00031 | 69-122 | CA_like |
| pfam00028 | 681-765 | Cadherin |
| cl15786 | 681-765 | CA_like superfamily |
Ontology Information
| HPRD ID | 2607 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.