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General Information
- Evidence
- Gene
- mRNA
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21128281 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 41 Stage : - | Genome-wide copy number profiling using high-resolution SNP arrays,Genomic real-time RT- PCR | Amplification | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] | Chromosome | 5 |
| Location | 5p14.3 |
| Start | 19473140 |
| End | 20575972 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1102833 |
| OMIM ID | 603019 |
| HGNC ID | HGNC:1757 |
| Unigene ID | Hs.317632 |
| Ensembl ID | ENSG00000145526 |
| PharmGKB ID | PA26291 |
mRNA Information
| mRNA ID | XM_005248228.2 |
|---|---|
| Exon | join(11..412,320369..320430,736632..737115,828638..828932, 854408..854527,963273..963440,984630..984817, 1004042..1004295,1031869..1032005,1055096..1055217, 1072765..1072882,1092322..1092573,1102158..1102944) | mRNA Sequence | Download Select all |
| Length | 3389 |
Protein Information
| Protein ID | XP_005248285.1 |
|---|---|
| Protein Name | cadherin 18, type 2 |
| Molecular Wt. (Da) | 87942 |
| Protein Sequence | Download Select all |
| Length | 790 |
| Uniprot ID | Q04721 |
| Ensembl Protein ID | ENSP00000256646 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1004 | CDH6 | 4305 | NP_004923.1 | in vitro;in vivo | 1 086 122 410 207 020 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 387-484 | Cadherin_repeat |
| cl15786 | 387-484 | CA_like superfamily |
| cd11304 | 163-264 | Cadherin_repeat |
| cl15786 | 163-264 | CA_like superfamily |
| cd11304 | 272-379 | Cadherin_repeat |
| cl15786 | 272-379 | CA_like superfamily |
| cd11304 | 59-155 | Cadherin_repeat |
| cl15786 | 59-155 | CA_like superfamily |
| cd11304 | 491-589 | Cadherin_repeat |
| cl15786 | 491-589 | CA_like superfamily |
| pfam01049 | 637-783 | Cadherin_C |
| cl03079 | 637-783 | Cadherin_C superfamily |
| smart00112 | 407-486 | CA |
| smart00112 | 182-266 | CA |
| pfam00028 | 388-479 | Cadherin |
| pfam00028 | 164-259 | Cadherin |
| smart00112 | 79-157 | CA |
| pfam00028 | 273-348 | Cadherin |
| smart00112 | 291-381 | CA |
| pfam00028 | 59-150 | Cadherin |
| pfam00028 | 492-589 | Cadherin |
| cd00031 | 71-155 | CA_like |
Ontology Information
| HPRD ID | 9137 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.