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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDH4 1002 cadherin 4, type 1, R-cadherin (retinal)  20- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15548679   2004Cell line : -

Source : ATCC

Sample Type : Tumor and Blood sample

No. of Sample : CRC 49, 17 adjecent normal tissue , 46 patients peripheral blood

Stage : Diagnostic marker

Methylation-specific PCR and RT-PCRMethylation-DH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis.


Gene Details



NC_000020.10 (59827482..60515673)

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Gene Type protein coding
Gene Family Cadherins / Major cadherins
Description This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]  
Chromosome 20
Location 20q13.3
Start 59827482  
End 60515673  
Strand +  
Gene Sequence

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Length 688192  
OMIM ID 603006   
HGNC ID HGNC:1763   
Unigene ID Hs.473231   
Ensembl ID ENSG00000179242   
PharmGKB ID PA26300   

mRNA Information


mRNA ID NM_001794.4
Exon join(1..145,2401..2512,491138..491364,520578..520757, 592243..592398,600329..600473,621303..621475, 642485..642622,657997..658182,671026..671279, 671909..672051,675765..675998,677184..677417, 680560..680699,681631..681795,684312..688192)  
mRNA Sequence

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Length 6530  



CDS Information


   
Location89..2839
CDS Sequence

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CCDS ID CCDS13488.1



Protein Information


      
Protein IDNP_001785.2
Protein Namecadherin 4, type 1, R-cadherin (retinal)
Molecular Wt. (Da)0
Protein Sequence

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Length 916  
Uniprot IDP29475
Ensembl Protein ID ENSP00000320758  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1000CDH2226NP_001783.2in vivo10662782   


Pathway Information


      
Pathway Name Pathway ID
Cell adhesion molecules (CAMs) hsa04514


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11304281-388  Cadherin_repeat
cl15786281-388  CA_like superfamily
cd11304514-611  Cadherin_repeat
cl15786514-611  CA_like superfamily
cd11304396-503  Cadherin_repeat
cl15786396-503  CA_like superfamily
pfam01049757-913  Cadherin_C
cl03079757-913  Cadherin_C superfamily
pfam0875830-119  Cadherin_pro
cl0739130-119  Cadherin_pro superfamily
smart0105531-117  Cadherin_pro
pfam00028282-383  Cadherin
smart00112300-390  CA
pfam00028514-606  Cadherin
smart00112530-613  CA
cd00031173-273  CA_like
cl15786173-273  CA_like superfamily
cd11304176-273  Cadherin_repeat
pfam00028397-498  Cadherin
smart00112195-275  CA
pfam00028174-268  Cadherin
smart00112414-505  CA
pfam00028619-711  Cadherin
cl15786619-711  CA_like superfamily
smart00112634-716  CA
cd05645304-423  M20_peptidase_T
cl14876304-423  Zinc_peptidase_like superfamily


Ontology Information


   
HPRD ID1224
Molecular ClassAdhesion molecule
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO