Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH4 | 1002 | cadherin 4, type 1, R-cadherin (retinal)  | 20 | -  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15548679    | 2004 | Cell line : - Source : ATCC Sample Type : Tumor and Blood sample No. of Sample : CRC 49, 17 adjecent normal tissue , 46 patients peripheral blood Stage : Diagnostic marker | Methylation-specific PCR and RT-PCR | Methylation | - | DH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]   | Chromosome | 20 |
| Location | 20q13.3 |
| Start | 59827482   |
| End | 60515673   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 688192   |
| OMIM ID | 603006    |
| HGNC ID | HGNC:1763    |
| Unigene ID | Hs.473231    |
| Ensembl ID | ENSG00000179242    |
| PharmGKB ID | PA26300    |
mRNA Information
| mRNA ID | NM_001794.4 |
|---|---|
| Exon | join(1..145,2401..2512,491138..491364,520578..520757, 592243..592398,600329..600473,621303..621475, 642485..642622,657997..658182,671026..671279, 671909..672051,675765..675998,677184..677417, 680560..680699,681631..681795,684312..688192)   | mRNA Sequence |    Download   Select all |
| Length | 6530   |
CDS Information
| Location | 89..2839 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS13488.1 |    
Protein Information
| Protein ID | NP_001785.2 |
|---|---|
| Protein Name | cadherin 4, type 1, R-cadherin (retinal) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 916   |
| Uniprot ID | P29475 |    
| Ensembl Protein ID | ENSP00000320758   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1000 |    CDH2 |    226 |    NP_001783.2 |    in vivo |    10662782    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) |    hsa04514 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 281-388  | Cadherin_repeat |
| cl15786 | 281-388  | CA_like superfamily |
| cd11304 | 514-611  | Cadherin_repeat |
| cl15786 | 514-611  | CA_like superfamily |
| cd11304 | 396-503  | Cadherin_repeat |
| cl15786 | 396-503  | CA_like superfamily |
| pfam01049 | 757-913  | Cadherin_C |
| cl03079 | 757-913  | Cadherin_C superfamily |
| pfam08758 | 30-119  | Cadherin_pro |
| cl07391 | 30-119  | Cadherin_pro superfamily |
| smart01055 | 31-117  | Cadherin_pro |
| pfam00028 | 282-383  | Cadherin |
| smart00112 | 300-390  | CA |
| pfam00028 | 514-606  | Cadherin |
| smart00112 | 530-613  | CA |
| cd00031 | 173-273  | CA_like |
| cl15786 | 173-273  | CA_like superfamily |
| cd11304 | 176-273  | Cadherin_repeat |
| pfam00028 | 397-498  | Cadherin |
| smart00112 | 195-275  | CA |
| pfam00028 | 174-268  | Cadherin |
| smart00112 | 414-505  | CA |
| pfam00028 | 619-711  | Cadherin |
| cl15786 | 619-711  | CA_like superfamily |
| smart00112 | 634-716  | CA |
| cd05645 | 304-423  | M20_peptidase_T |
| cl14876 | 304-423  | Zinc_peptidase_like superfamily |
Ontology Information
| HPRD ID | 1224 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
