Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 7779716 | 1995 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting , Immunohistochemistry | Up-regulation | - | Results suggest that an increase in the expression of cdk2/cdc2 in colorectal cancer may have prevented pRB from braking the cell cycle through phosphorylation. |
| 9664116 | 1998 | Cell line : HCT 116, LoVo, HT 29, Colo 320DM Source : - Sample Type : CRA,CRC tumor and Normal tissue No. of Sample : 65 Stage : TNM stage I-IV | Immunohistochemistry | Up-regulation | - | Authors findings suggest that inhibition of cdk2/cdc2 may be a useful strategy against colon cancer. cdk2/cdc2 is remarkably upregulated together with a malignant change. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cyclin-dependent kinases |
| Description | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q13 |
| Start | 55966769 |
| End | 55972789 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6021 |
| OMIM ID | 116953 |
| HGNC ID | HGNC:1771 |
| Unigene ID | Hs.19192 |
| Ensembl ID | ENSG00000123374 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011537732.1 |
|---|---|
| Exon | join(1..356,1089..1166,1281..1401,2010..2180,2707..2808, 3830..3973,4276..4479,4753..6021) | mRNA Sequence | Download Select all |
| Length | 2325 |
CDS Information
| Location | join(241..356,1089..1166,1281..1401,2010..2180,2707..2808, 3830..3973,4276..4479,4753..4857) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001789.2 |
|---|---|
| Protein Name | Cyclin-dependent kinase 2 |
| Molecular Wt. (Da) | 33799 |
| Protein Sequence | Download Select all |
| Length | 298 |
| Uniprot ID | Q13490 |
| Ensembl Protein ID | ENSP00000227758 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 14 |
| Y | Phosphorylation | 15 |
| T | Phosphorylation | 160 |
| T | Phosphorylation | 14 |
| Y | Phosphorylation | 15 |
| T | Phosphorylation | 160 |
| T | Dephosphorylation | 14 |
| Y | Dephosphorylation | 15 |
| T | Dephosphorylation | 14 |
| Y | Dephosphorylation | 15 |
| T | Dephosphorylation | 160 |
| T | Dephosphorylation | 160 |
| T | Phosphorylation | 160 |
| T | Phosphorylation | 160 |
| Y | Phosphorylation | 15 |
| Y | Phosphorylation | 19;- |
| Y | Phosphorylation | 19;- |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 46 |
| T | Phosphorylation | 158 |
| Y | Phosphorylation | 159 |
| K | Acetylation | 6 |
| K | Acetylation | 6 |
| T | Phosphorylation | 39 |
| T | Phosphorylation | 39 |
Enzyme Information
| EC | 2.7.11.22 |
|---|---|
| Name | cyclin-dependent kinase Bur1 Bur1 Cdk Cak1 Cak1p cdc2 cdc2 kinase Cdc28p CDK cdk-activating kinase Cdk-activating protein kinase cdk1 cdk2 Cdk2 cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 cdk9 cyclin A-activated cdc2 cyclin A-activated cdk2 cyclin D-cdk6 kinase cyclin D-dependent kinase cyclin E kinase cyclin-A associated kinase cyclin-dependent kinase 6 cyclin-dependent kinase-2 cyclin-dependent kinase-4 cyclin-dependent protein kinase activating kinase cyk D-type cyclin kinase nclk neuronal cdc2-like kinase PCTAIRE-1 STK25 |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases |
| Sysname | ATP:cyclin phosphotransferase |
| Substrate | ATP [CPD:C00002]; protein |
| Product | ADP [CPD:C00008]; phosphoprotein |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo | 10373534 |
| 898 | CCNE1 | 455 | NP_001229.1 | in vitro;in vivo | 138 828 814 536 078 |
| 902 | CCNH | 9059 | NP_001230.1 | in vitro | 9464540 |
| 990 | CDC6 | 4022 | NP_001245.1 | in vitro;in vivo | 988 919 610 339 564 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 12839982 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vitro | 1 297 255 591 928 730 000 000 000 000 000 |
| 1045 | CDX2 | 2622 | NP_001256.2 | in vitro;in vivo | 16027724 |
| 1050 | CEBPA | 296 | NP_004355.2 | in vitro;in vivo | 11684017 |
| 1163 | CKS1B | 299 | NP_001817.1 | in vitro;yeast 2-hybrid | 860 131 012 140 288 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vivo | 10330164 |
| 2305 | FOXM1 | 3823 | NP_973731.1 | in vitro | 15024056 |
| 3398 | ID2 | 2664 | NP_002157.2 | in vitro;in vivo | 9029153 |
| 3399 | ID3 | 2608 | NP_002158.3 | in vitro;in vivo | 9372912 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro;in vivo | 15241418 |
| 4173 | MCM4 | 9094 | NP_005905.2 | in vitro;in vivo | 1 651 968 716 517 720 |
| 4605 | MYBL2 | 3247 | NP_002457.1 | in vitro;in vivo | 98 409 321 009 577 200 000 000 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro | 9710583 |
| 4800 | NFYA | 1793 | NP_002496.1 | in vitro;in vivo | 12857729 |
| 4998 | ORC1L | 3544 | NP_004144.2 | in vitro | 11931757 |
| 5424 | POLD1 | 8882 | NP_002682.2 | in vitro | 9545286 |
| 5425 | POLD2 | 15982 | NP_006221.1 | in vitro | 16479163 |
| 5573 | PRKAR1A | 1786 | NP_002725.1 | in vitro;in vivo | 16582606 |
| 5744 | PTHLH | 1348 | NP_945316.1 | in vitro;in vivo | 10373465 |
| 5771 | PTPN2 | 6768 | NP_002819.1 | in vitro;in vivo | 15030318 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro | 87 566 249 315 635 900 000 000 000 000 000 000 000 000 000 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 10 884 347 120 644 700 000 000 000 000 000 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vitro;in vivo | 12676926 |
| 7290 | HIRA | 2583 | NP_003316.3 | in vitro;in vivo | 11238922 |
| 7319 | UBE2A | 2422 | NP_003327.2 | in vivo | 11953320 |
| 7343 | UBTF | 2814 | NP_055048.1 | in vitro;in vivo | 1 169 864 110 202 150 |
| 8161 | COIL | 2605 | NP_004636.1 | in vitro;in vivo | 11102515 |
| 8317 | CDC7 | 10345 | NP_003494.1 | in vitro | 10846177 |
| 9055 | PRC1 | 17899 | NP_003972.1 | in vitro;in vivo | 9885575 |
| 9738 | - | 10848 | NP_055526.3 | in vitro | 12361598 |
| 51343 | FZR1 | 4687 | NP_001129670.1 | in vitro;in vivo | 12560341 |
| 64061 | TSPYL2 | 6713 | NP_071400.1 | in vitro;in vivo | 11395479 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Epstein-Barr virus infection | hsa05169 |
| FoxO signaling pathway | hsa04068 |
| Hepatitis B | hsa05161 |
| Herpes simplex infection | hsa05168 |
| Measles | hsa05162 |
| Oocyte meiosis | hsa04114 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1AQ1 |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | CYCLIN-DEPENDENT PROTEIN KINASE 2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07860 | 3-286 | STKc_CDK2_3 |
| cl21453 | 3-286 | PKc_like superfamily |
| cd07835 | 4-286 | STKc_CDK1_CdkB_like |
| cd07829 | 4-286 | STKc_CDK_like |
| cd07861 | 3-286 | STKc_CDK1_euk |
| cd07836 | 3-286 | STKc_Pho85 |
| cd07839 | 3-286 | STKc_CDK5 |
| cd07837 | 2-286 | STKc_CdkB_plant |
| cd07844 | 4-286 | STKc_PCTAIRE_like |
| cd07841 | 3-294 | STKc_CDK7 |
| cd07843 | 2-286 | STKc_CDC2L1 |
| cd07840 | 4-286 | STKc_CDK9_like |
| cd07838 | 4-286 | STKc_CDK4_6_like |
| cd07873 | 1-289 | STKc_PCTAIRE1 |
| cd07871 | 1-286 | STKc_PCTAIRE3 |
| cd07832 | 3-286 | STKc_CCRK |
| cd07845 | 3-294 | STKc_CDK10 |
| cd07872 | 1-289 | STKc_PCTAIRE2 |
| cd05118 | 4-286 | STKc_CMGC |
| cd07830 | 4-286 | STKc_MAK_like |
| cd07870 | 3-286 | STKc_PFTAIRE2 |
| cd07842 | 4-286 | STKc_CDK8_like |
| cd07834 | 4-292 | STKc_MAPK |
| cd07863 | 4-286 | STKc_CDK4 |
| cd07866 | 1-286 | STKc_BUR1 |
| cd07833 | 2-286 | STKc_CDKL |
| cd07865 | 4-286 | STKc_CDK9 |
| cd07869 | 2-289 | STKc_PFTAIRE1 |
| cd07862 | 2-286 | STKc_CDK6 |
| cd07852 | 4-292 | STKc_MAPK15-like |
| cd14137 | 7-289 | STKc_GSK3 |
| cd07864 | 1-285 | STKc_CDK12 |
| cd07847 | 2-286 | STKc_CDKL1_4 |
| cd07846 | 2-286 | STKc_CDKL2_3 |
| cd07855 | 2-287 | STKc_ERK5 |
| cd07849 | 2-287 | STKc_ERK1_2_like |
| cd07851 | 4-286 | STKc_p38 |
| cd07858 | 10-287 | STKc_TEY_MAPK |
| cd07831 | 7-286 | STKc_MOK |
| cd07857 | 3-292 | STKc_MPK1 |
| cd06606 | 3-286 | STKc_MAPKKK |
| cd00180 | 10-284 | PKc |
| cd07853 | 4-288 | STKc_NLK |
| cd14132 | 1-287 | STKc_CK2_alpha |
| cd07880 | 2-292 | STKc_p38gamma |
| cd07879 | 2-295 | STKc_p38delta |
| cd14003 | 3-285 | STKc_AMPK-like |
| cd07878 | 2-292 | STKc_p38beta |
| cd07856 | 2-285 | STKc_Sty1_Hog1 |
| cd14014 | 3-282 | STKc_PknB_like |
| cd07848 | 4-286 | STKc_CDKL5 |
| cd07877 | 2-292 | STKc_p38alpha |
| cd05122 | 4-286 | PKc_STE |
| cd05117 | 3-285 | STKc_CAMK |
| cd14210 | 4-286 | PKc_DYRK |
| cd07850 | 4-285 | STKc_JNK |
| cd14133 | 4-286 | PKc_DYRK_like |
| cd07859 | 4-291 | STKc_TDY_MAPK |
| cd07854 | 4-292 | STKc_MAPK4_6 |
| cd06627 | 3-286 | STKc_Cdc7_like |
| cd08215 | 3-286 | STKc_Nek |
| cd07867 | 9-286 | STKc_CDC2L6 |
| cd07868 | 9-286 | STKc_CDK8 |
| cd14008 | 10-286 | STKc_LKB1_CaMKK |
| cd14007 | 3-287 | STKc_Aurora |
| cd14002 | 2-285 | STKc_STK36 |
| cd05123 | 10-286 | STKc_AGC |
| cd14009 | 10-285 | STKc_ATG1_ULK_like |
| cd06614 | 4-287 | STKc_PAK |
| cd08224 | 3-281 | STKc_Nek6_7 |
| cd07874 | 1-296 | STKc_JNK3 |
| cd06623 | 2-287 | PKc_MAPKK_plant_like |
| cd06632 | 5-285 | STKc_MEKK1_plant |
| cd14212 | 7-286 | PKc_YAK1 |
| cd07876 | 1-285 | STKc_JNK2 |
| cd07875 | 1-285 | STKc_JNK1 |
| cd14226 | 1-287 | PKc_DYRK1 |
| cd14119 | 10-286 | STKc_LKB1 |
| cd06612 | 2-286 | STKc_MST1_2 |
| cd14081 | 9-286 | STKc_BRSK1_2 |
| cd08217 | 3-286 | STKc_Nek2 |
| cd13994 | 10-286 | STKc_HAL4_like |
| cd13999 | 10-274 | STKc_MAP3K-like |
| cd14069 | 2-286 | STKc_Chk1 |
| cd13993 | 3-277 | STKc_Pat1_like |
| cd06626 | 5-285 | STKc_MEKK4 |
| cd05579 | 10-289 | STKc_MAST_like |
| cd14019 | 2-286 | STKc_Cdc7 |
| cd14098 | 4-285 | STKc_Rad53_Cds1 |
| cd14099 | 4-286 | STKc_PLK |
| cd14131 | 4-285 | PKc_Mps1 |
| cd14074 | 8-285 | STKc_SNRK |
| cd08529 | 3-284 | STKc_FA2-like |
| cd14663 | 10-285 | STKc_SnRK3 |
| cd14080 | 9-286 | STKc_TSSK-like |
| cd14121 | 8-285 | STKc_ULK3 |
| cd14134 | 7-286 | PKc_CLK |
| cd06611 | 2-291 | STKc_SLK_like |
| cd06613 | 4-286 | STKc_MAP4K3_like |
| cd05581 | 2-286 | STKc_PDK1 |
| cd06605 | 2-287 | PKc_MAPKK |
| cd14225 | 7-286 | PKc_DYRK4 |
| cd06610 | 8-286 | STKc_OSR1_SPAK |
| cd06625 | 3-286 | STKc_MEKK3_like |
| cd08530 | 3-284 | STKc_CNK2-like |
| cd14136 | 7-286 | STKc_SRPK |
| cd14211 | 4-285 | STKc_HIPK |
| cd06628 | 10-285 | STKc_Byr2_like |
| cd06917 | 4-198 | STKc_NAK1_like |
| cd08228 | 1-206 | STKc_Nek6 |
| cd06629 | 6-285 | STKc_Bck1_like |
| cd06644 | 2-294 | STKc_STK10 |
| cd14086 | 2-285 | STKc_CaMKII |
| cd00192 | 8-199 | PTKc |
| cd14135 | 7-286 | STKc_PRP4 |
| cd14224 | 10-222 | PKc_DYRK2_3 |
| cd06609 | 4-285 | STKc_MST3_like |
| cd13996 | 2-281 | STKc_EIF2AK |
| cd14116 | 1-285 | STKc_Aurora-A |
| cd14079 | 3-286 | STKc_AMPK_alpha |
| cd14073 | 4-207 | STKc_NUAK |
| cd14092 | 6-293 | STKc_MSK_C |
| cd14071 | 4-286 | STKc_SIK |
| cd06647 | 4-287 | STKc_PAK_I |
| cd14095 | 4-284 | STKc_DCKL |
| cd13997 | 3-284 | PKc_Wee1_like |
| cd05570 | 10-289 | STKc_PKC |
| cd14162 | 10-286 | STKc_TSSK4-like |
| cd14046 | 4-283 | STKc_EIF2AK4_GCN2_rpt2 |
| cd08220 | 3-284 | STKc_Nek8 |
| cd08218 | 4-285 | STKc_Nek1 |
| cd08225 | 3-286 | STKc_Nek5 |
| cd05611 | 10-289 | STKc_Rim15_like |
| cd13983 | 8-286 | STKc_WNK |
| cd14006 | 10-284 | STKc_MLCK-like |
| cd05578 | 3-286 | STKc_Yank1 |
| cd06655 | 2-296 | STKc_PAK2 |
| cd06648 | 2-286 | STKc_PAK_II |
| cd14118 | 10-284 | STKc_CAMKK |
| cd14084 | 9-284 | STKc_Chk2 |
| cd14091 | 8-288 | STKc_RSK_C |
| cd14010 | 3-285 | STKc_ULK4 |
| cd14072 | 3-217 | STKc_MARK |
| cd14096 | 2-285 | STKc_RCK1-like |
| cd14078 | 2-284 | STKc_MELK |
| cd05572 | 10-288 | STKc_cGK |
| cd06624 | 10-285 | STKc_ASK |
| cd14093 | 8-286 | STKc_PhKG |
| cd14077 | 3-285 | STKc_Kin1_2 |
| cd05580 | 2-289 | STKc_PKA_like |
| cd06643 | 2-296 | STKc_SLK |
| cd08229 | 1-206 | STKc_Nek7 |
| cd06656 | 2-296 | STKc_PAK3 |
| cd14120 | 10-285 | STKc_ULK1_2-like |
| cd06630 | 3-286 | STKc_MEKK1 |
| cd06631 | 4-285 | STKc_YSK4 |
| cd14229 | 4-285 | STKc_HIPK3 |
| cd14094 | 8-298 | STKc_CASK |
| cd13985 | 3-209 | STKc_GAK_like |
| cd05573 | 2-289 | STKc_ROCK_NDR_like |
| cd06654 | 2-296 | STKc_PAK1 |
| cd06659 | 1-292 | STKc_PAK6 |
| cd13982 | 8-286 | STKc_IRE1 |
| cd14185 | 10-285 | STKc_DCKL3 |
| cd14052 | 4-284 | PTKc_Wee1_fungi |
| cd14227 | 4-285 | STKc_HIPK2 |
| cd14117 | 1-293 | STKc_Aurora-B_like |
| cd06621 | 2-291 | PKc_Pek1_like |
| cd05619 | 1-289 | STKc_nPKC_theta |
| cd05577 | 10-289 | STKc_GRK |
| cd14075 | 9-276 | STKc_NIM1 |
| cd08222 | 7-285 | STKc_Nek11 |
| cd08223 | 4-285 | STKc_Nek4 |
| cd05592 | 10-289 | STKc_nPKC_theta_like |
| cd14083 | 8-284 | STKc_CaMKI |
| cd06622 | 5-285 | PKc_PBS2_like |
| cd06650 | 2-287 | PKc_MEK1 |
| cd08219 | 10-282 | STKc_Nek3 |
| cd06607 | 4-200 | STKc_TAO |
| cd06633 | 2-203 | STKc_TAO3 |
| cd14103 | 10-284 | STKc_MLCK |
| cd14161 | 4-197 | STKc_NUAK2 |
| cd14165 | 10-286 | STKc_TSSK1_2-like |
| cd14181 | 2-286 | STKc_PhKG2 |
| cd05612 | 2-216 | STKc_PRKX_like |
| cd14228 | 3-285 | STKc_HIPK1 |
| cd05038 | 2-199 | PTKc_Jak_rpt2 |
| cd14186 | 2-285 | STKc_PLK4 |
| cd14199 | 1-287 | STKc_CaMKK2 |
| cd14214 | 2-286 | PKc_CLK3 |
| cd14058 | 10-203 | STKc_TAK1 |
| cd06608 | 4-285 | STKc_myosinIII_N_like |
| cd05584 | 10-289 | STKc_p70S6K |
| cd14004 | 4-286 | STKc_PASK |
| cd14107 | 8-286 | STKc_obscurin_rpt1 |
| cd14085 | 1-285 | STKc_CaMKIV |
| cd14065 | 10-223 | PKc_LIMK_like |
| cd05599 | 2-289 | STKc_NDR_like |
| cd06620 | 2-294 | PKc_Byr1_like |
| cd13979 | 8-208 | STKc_Mos |
| cd14097 | 9-285 | STKc_STK33 |
| cd06639 | 2-287 | STKc_myosinIIIB_N |
| cd14202 | 4-287 | STKc_ULK1 |
| cd05620 | 10-289 | STKc_nPKC_delta |
| cd14164 | 8-206 | STKc_TSSK6-like |
| cd14049 | 4-196 | STKc_EIF2AK1_HRI |
| cd14167 | 2-285 | STKc_CaMKI_alpha |
| cd05609 | 3-289 | STKc_MAST |
| cd14082 | 8-210 | STKc_PKD |
| cd14106 | 1-286 | STKc_DRAK |
| cd05590 | 10-289 | STKc_nPKC_eta |
| cd06619 | 2-204 | PKc_MKK5 |
| cd05079 | 4-198 | PTKc_Jak1_rpt2 |
| cd05585 | 10-289 | STKc_YPK1_like |
| cd05571 | 10-289 | STKc_PKB |
| cd14050 | 4-284 | PKc_Myt1 |
| cd14154 | 10-199 | STKc_LIMK |
| cd14070 | 9-198 | STKc_HUNK |
| cd14166 | 2-285 | STKc_CaMKI_gamma |
| cd06615 | 2-293 | PKc_MEK |
| cd14182 | 2-287 | STKc_PhKG1 |
| cd14665 | 4-285 | STKc_SnRK2-3 |
| cd06658 | 9-297 | STKc_PAK5 |
| cd14005 | 3-286 | STKc_PIM |
| cd06653 | 2-285 | STKc_MEKK3_like_u1 |
| cd14169 | 8-285 | STKc_CaMKI_beta |
| cd06635 | 4-200 | STKc_TAO1 |
| cd14048 | 3-197 | STKc_EIF2AK3_PERK |
| cd14198 | 1-286 | STKc_DRAK2 |
| cd14190 | 8-286 | STKc_MLCK2 |
| cd14114 | 8-286 | STKc_Twitchin_like |
| cd06646 | 2-285 | STKc_MAP4K5 |
| cd06617 | 2-287 | PKc_MKK3_6 |
| cd13986 | 7-283 | STKc_16 |
| cd13990 | 10-196 | STKc_TLK |
| cd13989 | 10-198 | STKc_IKK |
| cd05600 | 1-286 | STKc_Sid2p_like |
| cd14066 | 10-200 | STKc_IRAK |
| cd14201 | 4-287 | STKc_ULK2 |
| cd14047 | 2-196 | STKc_EIF2AK2_PKR |
| cd14180 | 4-207 | STKc_MSK2_C |
| cd14194 | 1-285 | STKc_DAPK1 |
| cd06641 | 2-296 | STKc_MST3 |
| cd14059 | 10-198 | STKc_MAP3K12_13 |
| cd14111 | 8-285 | STKc_SPEG_rpt2 |
| cd08221 | 4-286 | STKc_Nek9 |
| cd05601 | 2-297 | STKc_CRIK |
| cd06634 | 4-200 | STKc_TAO2 |
| cd06638 | 2-203 | STKc_myosinIIIA_N |
| cd13978 | 10-215 | STKc_RIP |
| cd06657 | 9-297 | STKc_PAK4 |
| cd14216 | 4-286 | STKc_SRPK1 |
| cd06651 | 3-287 | STKc_MEKK3 |
| cd14105 | 8-285 | STKc_DAPK |
| cd05575 | 10-289 | STKc_SGK |
| cd14101 | 10-287 | STKc_PIM2 |
| cd08528 | 3-203 | STKc_Nek10 |
| cd05630 | 4-289 | STKc_GRK6 |
| cd06645 | 2-285 | STKc_MAP4K3 |
| cd14175 | 8-285 | STKc_RSK1_C |
| cd05582 | 10-222 | STKc_RSK_N |
| cd05591 | 10-289 | STKc_nPKC_epsilon |
| cd06649 | 2-213 | PKc_MEK2 |
| cd14200 | 9-285 | STKc_CaMKK1 |
| cd14179 | 6-288 | STKc_MSK1_C |
| cd14163 | 4-213 | STKc_TSSK3-like |
| cd06652 | 10-242 | STKc_MEKK2 |
| cd05080 | 4-199 | PTKc_Tyk2_rpt2 |
| cd14184 | 2-285 | STKc_DCKL2 |
| cd06642 | 2-296 | STKc_STK25 |
| cd14221 | 10-199 | STKc_LIMK1 |
| cd14209 | 2-289 | STKc_PKA |
| cd14222 | 10-197 | STKc_LIMK2 |
| cd14076 | 10-285 | STKc_Kin4 |
| cd14215 | 2-286 | PKc_CLK2 |
| cd05032 | 1-198 | PTKc_InsR_like |
| cd05593 | 1-289 | STKc_PKB_gamma |
| cd14113 | 2-286 | STKc_Trio_C |
| cd14087 | 10-285 | STKc_PSKH1 |
| cd05605 | 10-289 | STKc_GRK4_like |
| cd14176 | 2-296 | STKc_RSK2_C |
| cd14213 | 2-286 | PKc_CLK1_4 |
| cd05083 | 3-204 | PTKc_Chk |
| cd05586 | 10-289 | STKc_Sck1_like |
| cd05574 | 4-289 | STKc_phototropin_like |
| cd14205 | 7-246 | PTKc_Jak2_rpt2 |
| cd13987 | 10-278 | STKc_SBK1 |
| cd05607 | 4-292 | STKc_GRK7 |
| cd14090 | 8-285 | STKc_Mnk |
| cd05604 | 10-290 | STKc_SGK3 |
| cd14196 | 1-285 | STKc_DAPK2 |
| cd14193 | 3-285 | STKc_MLCK4 |
| cd05068 | 2-248 | PTKc_Frk_like |
| cd05587 | 10-287 | STKc_cPKC |
| cd05616 | 3-214 | STKc_cPKC_beta |
| cd05040 | 8-198 | PTKc_Ack_like |
| cd05595 | 10-291 | STKc_PKB_beta |
| cd14662 | 4-285 | STKc_SnRK2 |
| cd14037 | 6-274 | STKc_NAK_like |
| cd05148 | 2-240 | PTKc_Srm_Brk |
| cd05610 | 1-289 | STKc_MASTL |
| cd14192 | 7-283 | STKc_MLCK3 |
| cd13977 | 7-277 | STKc_PDIK1L |
| cd05041 | 8-240 | PTKc_Fes_like |
| cd06640 | 2-296 | STKc_MST4 |
| cd05039 | 1-196 | PTKc_Csk_like |
| cd14183 | 2-288 | STKc_DCKL1 |
| cd05067 | 2-240 | PTKc_Lck_Blk |
| cd05034 | 8-240 | PTKc_Src_like |
| cd14197 | 9-286 | STKc_DRAK1 |
| cd14168 | 2-285 | STKc_CaMKI_delta |
| cd14195 | 8-287 | STKc_DAPK3 |
| cd05603 | 10-197 | STKc_SGK2 |
| cd14109 | 8-286 | PK_Unc-89_rpt1 |
| cd05048 | 1-196 | PTKc_Ror |
| cd14178 | 8-285 | STKc_RSK3_C |
| cd14177 | 8-296 | STKc_RSK4_C |
| cd05060 | 8-240 | PTKc_Syk_like |
| cd05589 | 4-289 | STKc_PKN |
| cd05084 | 8-225 | PTKc_Fes |
| cd06636 | 4-196 | STKc_MAP4K4_6_N |
| cd14039 | 10-195 | STKc_IKK_alpha |
| cd05583 | 10-287 | STKc_MSK_N |
| cd14191 | 8-286 | STKc_MLCK1 |
| cd05631 | 4-289 | STKc_GRK4 |
| cd05072 | 2-225 | PTKc_Lyn |
| cd14218 | 4-286 | STKc_SRPK3 |
| cd05053 | 7-198 | PTKc_FGFR |
| cd05598 | 4-290 | STKc_LATS |
| cd05632 | 2-289 | STKc_GRK5 |
| cd14038 | 9-198 | STKc_IKK_beta |
| cd14000 | 10-228 | STKc_LRRK |
| cd05614 | 3-289 | STKc_MSK2_N |
| cd05059 | 7-246 | PTKc_Tec_like |
| cd14016 | 3-161 | STKc_CK1 |
| cd14156 | 10-209 | PKc_LIMK_like_unk |
| cd06637 | 4-288 | STKc_TNIK |
| cd06616 | 2-212 | PKc_MKK4 |
| cd05050 | 3-196 | PTKc_Musk |
| cd05052 | 9-225 | PTKc_Abl |
| cd14100 | 10-240 | STKc_PIM1 |
| cd05056 | 8-193 | PTKc_FAK |
| cd05073 | 2-240 | PTKc_Hck |
| cd05615 | 1-214 | STKc_cPKC_alpha |
| cd14155 | 10-199 | PKc_TESK |
| cd05112 | 7-246 | PTKc_Itk |
| cd14146 | 10-240 | STKc_MLK4 |
| cd14108 | 8-215 | STKc_SPEG_rpt1 |
| cd05618 | 1-215 | STKc_aPKC_iota |
| cd05097 | 8-198 | PTKc_DDR_like |
| cd14187 | 51-286 | STKc_PLK1 |
| cd06618 | 2-288 | PKc_MKK7 |
| cd05095 | 8-264 | PTKc_DDR2 |
| cd14089 | 8-284 | STKc_MAPKAPK |
| cd05033 | 7-198 | PTKc_EphR |
| cd14104 | 8-210 | STKc_Titin |
| cd05613 | 3-289 | STKc_MSK1_N |
| cd14012 | 50-285 | PK_eIF2AK_GCN2_rpt1 |
| cd14033 | 9-286 | STKc_WNK4 |
| cd05099 | 10-217 | PTKc_FGFR4 |
| cd05608 | 10-289 | STKc_GRK1 |
| cd05071 | 9-217 | PTKc_Src |
| cd14158 | 9-198 | STKc_IRAK4 |
| cd14020 | 9-286 | STKc_KIS |
| cd14088 | 18-283 | STKc_CaMK_like |
| cd13998 | 8-199 | STKc_TGFbR-like |
| cd05594 | 1-289 | STKc_PKB_alpha |
| cd14011 | 18-288 | PK_SCY1_like |
| cd14036 | 10-192 | STKc_GAK |
| cd05113 | 7-198 | PTKc_Btk_Bmx |
| cd05075 | 10-222 | PTKc_Axl |
| cd05090 | 7-198 | PTKc_Ror1 |
| cd14147 | 3-256 | STKc_MLK3 |
| cd14203 | 9-240 | PTKc_Src_Fyn_like |
| cd05602 | 3-197 | STKc_SGK1 |
| cd14013 | 8-286 | STKc_SNT7_plant |
| cd05069 | 9-240 | PTKc_Yes |
| cd14145 | 8-212 | STKc_MLK1 |
| cd14173 | 8-285 | STKc_Mnk2 |
| cd14027 | 13-241 | STKc_RIP1 |
| cd05621 | 2-225 | STKc_ROCK2 |
| cd14115 | 10-285 | STKc_Kalirin_C |
| cd14189 | 10-286 | STKc_PLK3 |
| cd05081 | 7-198 | PTKc_Jak3_rpt2 |
| cd14102 | 10-223 | STKc_PIM3 |
| cd14148 | 10-212 | STKc_MLK2 |
| cd05049 | 7-198 | PTKc_Trk |
| cd05096 | 8-257 | PTKc_DDR1 |
| cd05070 | 2-222 | PTKc_Fyn |
| cd14188 | 10-248 | STKc_PLK2 |
| cd05045 | 3-252 | PTKc_RET |
| cd14061 | 10-198 | STKc_MLK |
| cd05085 | 8-244 | PTKc_Fer |
| cd05116 | 9-195 | PTKc_Syk |
| cd05588 | 10-215 | STKc_aPKC |
| cd14060 | 11-205 | STKc_MLTK |
| cd14217 | 4-286 | STKc_SRPK2 |
| cd05617 | 1-203 | STKc_aPKC_zeta |
| cd05606 | 10-289 | STKc_beta_ARK |
| cd14063 | 8-296 | PK_KSR |
| cd13991 | 9-197 | STKc_NIK |
| cd05082 | 1-196 | PTKc_Csk |
| cd05074 | 10-240 | PTKc_Tyro3 |
| cd05622 | 2-224 | STKc_ROCK1 |
| cd05035 | 10-252 | PTKc_TAM |
| cd14110 | 9-190 | STKc_obscurin_rpt2 |
| cd05596 | 2-207 | STKc_ROCK |
| cd05046 | 2-198 | PTK_CCK4 |
| cd13988 | 10-203 | STKc_TBK1 |
| cd05098 | 10-217 | PTKc_FGFR1 |
| cd14053 | 8-199 | STKc_ACVR2 |
| cd05091 | 7-224 | PTKc_Ror2 |
| cd14062 | 10-223 | STKc_Raf |
| cd05092 | 9-198 | PTKc_TrkA |
| cd14172 | 10-285 | STKc_MAPKAPK3 |
| cd13995 | 10-283 | STKc_MAP3K8 |
| cd14031 | 9-290 | STKc_WNK3 |
| cd08216 | 16-289 | PK_STRAD |
| cd14174 | 8-287 | STKc_Mnk1 |
| cd05115 | 9-190 | PTKc_Zap-70 |
| cd14064 | 10-198 | PKc_TNNI3K |
| cd05101 | 10-217 | PTKc_FGFR2 |
| cd05063 | 5-198 | PTKc_EphR_A2 |
| cd05058 | 8-201 | PTKc_Met_Ron |
| cd13968 | 10-147 | PKc_like |
| cd14223 | 10-289 | STKc_GRK2 |
| cd14054 | 8-207 | STKc_BMPR2_AMHR2 |
| cd14040 | 2-297 | STKc_TLK1 |
| cd14112 | 2-192 | STKc_Unc-89_rpt2 |
| cd05597 | 2-196 | STKc_DMPK_like |
| cd05093 | 9-198 | PTKc_TrkB |
| cd05624 | 2-215 | STKc_MRCK_beta |
| cd14204 | 10-255 | PTKc_Mer |
| cd05633 | 1-203 | STKc_GRK3 |
| cd05065 | 3-198 | PTKc_EphR_B |
| cd05100 | 10-217 | PTKc_FGFR3 |
| cd05061 | 2-198 | PTKc_InsR |
| cd14171 | 8-285 | STKc_MAPKAPK5 |
| cd05626 | 4-225 | STKc_LATS2 |
| cd05057 | 4-198 | PTKc_EGFR_like |
| cd14030 | 9-290 | STKc_WNK1 |
| cd14041 | 10-297 | STKc_TLK2 |
| cd05043 | 2-242 | PTK_Ryk |
| cd05051 | 1-198 | PTKc_DDR |
| cd05576 | 61-286 | STKc_RPK118_like |
| cd05629 | 2-195 | STKc_NDR_like_fungal |
| cd05047 | 10-198 | PTKc_Tie |
| cd08226 | 18-291 | PK_STRAD_beta |
| cd14664 | 10-198 | STK_BAK1_like |
| cd05627 | 1-225 | STKc_NDR2 |
| cd13980 | 18-281 | STKc_Vps15 |
| cd05094 | 9-198 | PTKc_TrkC |
| cd14024 | 60-285 | PK_TRB3 |
| cd14017 | 3-200 | STKc_TTBK |
| cd05114 | 7-246 | PTKc_Tec_Rlk |
| cd14068 | 10-233 | STKc_LRRK2 |
| cd05044 | 10-240 | PTKc_c-ros |
| cd14001 | 8-210 | PKc_TOPK |
| cd05055 | 9-198 | PTKc_PDGFR |
| cd14032 | 9-290 | STKc_WNK2_like |
| cd14207 | 92-213 | PTKc_VEGFR1 |
| cd05054 | 6-223 | PTKc_VEGFR |
| cd05108 | 4-198 | PTKc_EGFR |
| cd05623 | 2-215 | STKc_MRCK_alpha |
| cd14159 | 10-202 | STKc_IRAK1 |
| cd05628 | 2-197 | STKc_NDR1 |
| cd05066 | 6-198 | PTKc_EphR_A |
| cd14170 | 10-285 | STKc_MAPKAPK2 |
| cd08227 | 17-291 | PK_STRAD_alpha |
| cd05089 | 2-198 | PTKc_Tie1 |
| cd05110 | 4-198 | PTKc_HER4 |
| cd14056 | 8-257 | STKc_TGFbR_I |
| cd05036 | 2-150 | PTKc_ALK_LTK |
| cd14022 | 60-286 | PK_TRB2 |
| cd14051 | 4-284 | PTKc_Wee1 |
| cd13992 | 27-222 | PK_GC |
| PLN00009 | 1-289 | PLN00009 |
| smart00220 | 4-286 | S_TKc |
| pfam00069 | 4-286 | Pkinase |
| PTZ00024 | 10-294 | PTZ00024 |
| PTZ00036 | 10-292 | PTZ00036 |
| COG0515 | 3-288 | SPS1 |
| smart00221 | 8-199 | STYKc |
| smart00219 | 5-199 | TyrKc |
| pfam07714 | 4-190 | Pkinase_Tyr |
| PLN00034 | 1-285 | PLN00034 |
| PTZ00263 | 1-289 | PTZ00263 |
| PHA03209 | 3-289 | PHA03209 |
| PTZ00266 | 1-212 | PTZ00266 |
| PHA03210 | 1-286 | PHA03210 |
| PHA03212 | 4-295 | PHA03212 |
| TIGR03903 | 26-228 | TOMM_kin_cyc |
| PHA03207 | 50-286 | PHA03207 |
| PHA03211 | 46-287 | PHA03211 |
| PTZ00267 | 22-258 | PTZ00267 |
| PRK13184 | 1-204 | pknD |
| PLN03225 | 2-287 | PLN03225 |
| PTZ00283 | 10-207 | PTZ00283 |
| PHA03390 | 2-286 | pk1 |
| PTZ00426 | 2-289 | PTZ00426 |
| PTZ00284 | 108-297 | PTZ00284 |
Ontology Information
| HPRD ID | 3419 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P24941 | DB06616 | Bosutinib | SmallMoleculeDrug |