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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDKN1B | 1027 | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12 | KIP1; MEN4; CDKN4; MEN1B; P27KIP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17086168 | 2007 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : Health Study 121700 women and the Health Professional Follow-up Study 51500 Stage : - | MethyLight assays, Immunohistochemistry | Down-regulation | - | Downregulation of p27 (cyclin-dependent kinase inhibitor-1B, CDKN1B or KIP1) is caused by increased ubiquitin-mediated proteasomal degradation in colorectal cancer, and has been associated with poor prognosis. Downregulation of nuclear p27 is associated with CIMP-high and MSI-H in colorectal cancer. |
| 19082479 | 2009 | Cell line : - Source : Maggiore Hospital in Novara. Sample Type : CRC tumor and Normal tissue No. of Sample : 70 Stage : TNM stage I-IV | Western blotting and immunohistochemistry | Down-regulation | - | Results suggest that cytoplasmic p27Kip1 localization, associated or not with Akt activation, may contribute to colorectal tumorigenesis and metastasis and it may be useful as a negative prognostic factor for the outcome of patients with colorectal cancer. p27Kip1 protein expression, as evaluated by western blotting, was absent or reduced in about 63% of colorectal cancers compared with both peritumoral and normal tissue |
| 19276255 | 2009 | Cell line : - Source : North Central CancerTreatment Group, National Cancer Institute of Canada Clinical Trials Group, Eastern Cooperative Oncology Group, Southwest Oncology Group, and National Cancer Institute Cancer Trials Support Unit. Sample Type : CRC tumor and Normal tissue No. of Sample : 601 Stage : TNM stage I-IV | Trial structure and organization, Treatment, Characterization of tumor p27 status. | Down-regulation | - | Loss of p27 is associated with reduced survival in stage III colon cancer. Of 601 tumors analyzed, 207 (34.4%) showed p27 loss, 377 (62.8%) retained p27, and 17 (2.8%) were indeterminate. |
| 19505918 | 2009 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : Nurses Health Study 121,700 women and the Health Professionals Follow-up Study 51,500 men Stage : - | Measurement of Mortality, Pyrosequencing,Real-time PCR, Immunohistochemistry | Down-regulation | - | p27 alterations in colon cancer are associated with superior prognosis. |
| 19522032 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 65 Stage : TNM stage I-IV | Flow cytometry, Apoptosis by DNA fragment analysis, PCR, X-gal chemical staining, TUNEL Assay, Western Blotting | Unknown | - | p27mt has an obvious blocking effect on colorectal cancer cell cycle, and most cells were inhibited in phase G(0)/G(1). |
| 19764092 | 2009 | Cell line : LoVo Source : - Sample Type : - No. of Sample : - Stage : - | MTT , Flow cytometry, Immunocytochemistry, RT-PCR. | Unknown | - | Paeonol down-regulated COX-2 and up-regulated p27 in a dose- and time-dependent manner in HT-29 cells. p27 is up-regulated simultaneously and plays an important part in controlling cell proliferation and is a crucial factor in the Fas/FasL apoptosis pathway. |
| 21637966 | 2012 | Cell line : HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | A series of 65 CRC patients were analyzed for p27 and p21 expression in their tumors using immunohistochemistry. Forty-six percent of tumors showed positive nuclear p27 expression, whereas 72% of cases were completely p21 negative. p27 expression seems to be more powerful than p21 expression in providing useful prognostic information in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12p13.1-p1 |
| Start | 12717270 |
| End | 12722383 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5114 |
| OMIM ID | 600778 |
| HGNC ID | HGNC:1785 |
| Unigene ID | Hs.238990 |
| Ensembl ID | ENSG00000111276 |
| PharmGKB ID | PA105 |
mRNA Information
| mRNA ID | XM_011520623.1 |
|---|---|
| Exon | complement(<1..3) | mRNA Sequence | Download Select all |
| Length | 2413 |
CDS Information
| Location | join(571..1045,1556..1677) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8653.1 |
Protein Information
| Protein ID | NP_004055.1 |
|---|---|
| Protein Name | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Molecular Wt. (Da) | 21942 |
| Protein Sequence | Download Select all |
| Length | 198 |
| Uniprot ID | O15392 |
| Ensembl Protein ID | ENSP00000364086 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 10 |
| T | Phosphorylation | 187 |
| T | Phosphorylation | 157 |
| Y | Phosphorylation | 88 |
| Y | Phosphorylation | 88 |
| T | Phosphorylation | 187 |
| Y | Phosphorylation | 74 |
| Y | Phosphorylation | 74 |
| Y | Phosphorylation | 88 |
| Y | Phosphorylation | 88 |
| T | Phosphorylation | 198 |
| S | Phosphorylation | 140;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 595 | CCND1 | 1346 | NP_444284.1 | in vitro;in vivo | 74 785 821 090 865 500 000 000 |
| 890 | CCNA2 | 453 | NP_001228.1 | in vitro | 1 250 119 117 254 960 |
| 891 | CCNB1 | 454 | NP_114172.1 | in vitro | 8756624 |
| 896 | CCND3 | 452 | NP_001751.1 | in vitro;in vivo | 10342870 |
| 1018 | CDK3 | 446 | NP_001249.1 | in vivo | 9811456 |
| 1019 | CDK4 | 447 | NP_000066.1 | in vitro;in vivo | 1 090 865 516 326 700 |
| 1020 | CDK5 | 449 | NP_004926.1 | in vitro | 15890360 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo;yeast 2-hybrid | 11278754 |
| 3839 | KPNA3 | 3536 | NP_002258.2 | in vitro | 15057270 |
| 3841 | KPNA5 | 5179 | NP_002260.2 | in vitro | 15057270 |
| 3925 | STMN1 | 1047 | NP_001138926.1 | in vitro;in vivo;yeast 2-hybrid | 15652749 |
| 4176 | MCM7 | 1154 | NP_005907.3 | in vitro;in vivo;yeast 2-hybrid | 16289477 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | yeast 2-hybrid | 16189514 |
| 7345 | UCHL1 | 1877 | NP_004172.2 | in vivo;yeast 2-hybrid | 12082530 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vitro;in vivo | 15057270 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vitro;in vivo | 15057270 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vitro;in vivo | 12042314 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo | 12042314 |
| 10987 | COPS5 | 6888 | NP_006828.2 | in vivo | 15688030 |
| 245711 | SPDYA | 18095 | NP_877433.2 | in vitro;in vivo;yeast 2-hybrid | 12972555 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Epstein-Barr virus infection | hsa05169 |
| ErbB signaling pathway | hsa04012 |
| FoxO signaling pathway | hsa04068 |
| Hepatitis B | hsa05161 |
| HIF-1 signaling pathway | hsa04066 |
| Measles | hsa05162 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
| Transcriptional misregulation in cancer | hsa05202 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1H27 |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C |
| Molecule | CELL DIVISION PROTEIN KINASE 2 |
| Model | View |
Ontology Information
| HPRD ID | 4520 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.