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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDKN1C | 1028 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 11 | P57, KIP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21538272 | 2011 | Cell line : Caco2 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Western-blotting,MTT assay, flow cytometry | Down-regulation | - | miR-221 inhibits CDKN1C/P57 expression by post-transcriptional gene silencing to promote CRC development and progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 2904448 |
| End | 2907063 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2616 |
| OMIM ID | 600856 |
| HGNC ID | HGNC:1786 |
| Unigene ID | Hs.106070 |
| Ensembl ID | ENSG00000129757 |
| PharmGKB ID | PA26320 |
mRNA Information
| mRNA ID | XM_005252732.3 |
|---|---|
| Exon | join(1..183,351..615,1683..1818,1907..2599) | mRNA Sequence | Download Select all |
| Length | 1277 |
Protein Information
| Protein ID | XP_005252789.1 |
|---|---|
| Protein Name | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| Molecular Wt. (Da) | 19656 |
| Protein Sequence | Download Select all |
| Length | 175 |
| Uniprot ID | Q99743 |
| Ensembl Protein ID | ENSP00000338283 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 268 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1019 | CDK4 | 447 | NP_000066.1 | in vivo | 9106657 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro;in vivo | 10764802 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo | 9465025 |
| 9134 | CCNE2 | 4801 | NP_477097.1 | yeast 2-hybrid | 9840943 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 3843 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.