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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23028699 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | mRNA Expression Microarray, Sequencing and Combined Bisulfite Restriction Analysis (COBRA). | Methylation | - | The frequency of CDO1 methylation in tumors was 100% (21/21) and that in normal methylation was 0% (0/21), indicating that CDO1 is hypermethylated in CRC. A high level of CDO1 promoter methylation was also found in CRC cell lines (5/5, 100%), consistent with the bisulfite-sequencing and COBRA results. These results indicate that CDO1 is cancer-specifically methylated in CRC with high frequency. CRC cell lines (HCT116, HT29, DLD-1, RKO and SW480) were used. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 5 |
| Location | 5q23.2 |
| Start | 115804733 |
| End | 115816954 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12222 |
| OMIM ID | 603943 |
| HGNC ID | HGNC:1795 |
| Unigene ID | Hs.442378 |
| Ensembl ID | ENSG00000129596 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001801.2 |
|---|---|
| Exon | join(247..727,3697..3774,5640..5794,10437..10606, 11493..12222) | mRNA Sequence | Download Select all |
| Length | 1627 |
CDS Information
| Location | join(558..727,3697..3774,5640..5794,10437..10606, 11493..11522) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4121.1 |
Protein Information
| Protein ID | NP_001792.2 |
|---|---|
| Protein Name | Cysteine dioxygenase, type I |
| Molecular Wt. (Da) | 22841 |
| Protein Sequence | Download Select all |
| Length | 200 |
| Uniprot ID | P04114 |
| Ensembl Protein ID | ENSP00000233242 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 59 |
Enzyme Information
| EC | 1.13.11.20 |
|---|---|
| Name | cysteine dioxygenase cysteine oxidase |
| Class | Oxidoreductases; Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2; With incorporation of two atoms of oxygen |
| Sysname | L-cysteine:oxygen oxidoreductase |
| Substrate | L-cysteine [CPD:C00097]; O2 |
| Product | 3-sulfinoalanine |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cysteine and methionine metabolism | hsa00270 |
| Metabolic pathways | hsa01100 |
| Taurine and hypotaurine metabolism | hsa00430 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 133 |
|---|---|
| Molecular Class | Enzyme: Oxidoreductase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q16878 | DB00151 | L-Cysteine | SmallMoleculeDrug |