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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDT1 | 81620 | chromatin licensing and DNA replication factor 1 | 16 | DUP, RIS2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16273206 | 2005 | Cell line : Caco-2 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Western Blotting | Down-regulation | - | Cdt1 and Geminin expression are severely downregulated upon differentiation of Caco-2 cells |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011 | Chromosome | 16 |
| Location | 16q24.3 |
| Start | 88870186 |
| End | 88875666 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5481 |
| OMIM ID | 605525 |
| HGNC ID | HGNC:24576 |
| Unigene ID | Hs.122908 |
| Ensembl ID | ENSG00000167513 |
| PharmGKB ID | PA145008572 |
Protein Information
| Protein ID | NP_112190.2 |
|---|---|
| Protein Name | chromatin licensing and DNA replication factor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 546 |
| Uniprot ID | Q86UD0 |
| Ensembl Protein ID | ENSP00000386348 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 318 |
| T | Phosphorylation | 29 |
| S | Phosphorylation | 31 |
| S | Phosphorylation | 372 |
| S | Phosphorylation | 394 |
| T | Phosphorylation | 533 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 890 | CCNA2 | 453 | NP_001228.1 | in vitro;in vivo | 14993212 |
| 983 | CDK1 | 302 | NP_001777.1 | in vitro;in vivo | 14993212 |
| 988 | CDC5L | 4184 | NP_001244.1 | in vitro | 15232106 |
| 990 | CDC6 | 4022 | NP_001245.1 | in vitro;in vivo | 1 523 210 614 672 930 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro;in vivo | 14993212 |
| 4175 | MCM6 | 3485 | NP_005906.2 | in vitro;in vivo;yeast 2-hybrid | 12192004 |
| 4998 | ORC1L | 3544 | NP_004144.2 | in vitro | 15232106 |
| 4999 | ORC2L | 3112 | NP_006181.1 | in vitro | 15232106 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo | 1 640 725 216 482 210 |
| 6502 | SKP2 | 3256 | NP_005974.2 | in vitro;in vivo | 1 284 003 314 993 210 |
| 7314 | UBB | 6771 | NP_061828.1 | in vivo | 16407252 |
| 51053 | GMNN | 6783 | NP_056979.1 | in vitro;in vivo | 1 523 210 614 993 210 000 000 000 000 000 000 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08674 | 168-352 | Cdt1_m |
| cl07443 | 168-352 | Cdt1_m superfamily |
| cd08767 | 415-537 | Cdt1_c |
| cl14631 | 415-537 | Cdt1_c superfamily |
| smart01075 | 186-350 | CDT1 |
| pfam08839 | 186-350 | CDT1 |
| PRK07003 | 18-169 | PRK07003 |
| PRK07003 | 15-169 | PRK07003 |
| PHA03307 | 15-172 | PHA03307 |
| PHA03247 | 15-115 | PHA03247 |
| PTZ00449 | 13-159 | PTZ00449 |
| PRK14951 | 17-157 | PRK14951 |
| PRK12323 | 14-183 | PRK12323 |
Ontology Information
| HPRD ID | 11607 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.