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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CEACAM3 | 1084 | Carcinoembryonic antigen-related cell adhesion molecule 3 | 19 | CEA; CGM1; W264; W282; CD66D |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14512395 | 2003 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 505 Stage : - | Tumor Microarrays, Immunohistochemistry | Up-regulation | - | CEACAM6 expression might become useful as a marker to identify patients who are at especially high-risk of relapse. Expression of the cell adhesion molecule CEACAM6 in CRC is an independent prognostic factor allowing subdivision of patients into low- and high-risk groups. The prognostic significance of immunohistochemically detectable overexpression of CEACAM6 in patients with resectable CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, Immunoglobulin superfamily / V-set domain containing |
| Description | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] | Chromosome | 19 |
| Location | 19q13.2 |
| Start | 41796590 |
| End | 41811553 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14964 |
| OMIM ID | 609142 |
| HGNC ID | HGNC:1815 |
| Unigene ID | Hs.11 |
| Ensembl ID | ENSG00000170956 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001815.4 |
|---|---|
| Exon | join(1..152,1000..1359,12224..12341,13376..13428, 13734..13765,14243..14308,14583..14964) | mRNA Sequence | Download Select all |
| Length | 1163 |
CDS Information
| Location | join(89..152,1000..1359,12224..12341,13376..13428, 13734..13765,14243..14308,14583..14648) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12586.2 |
Protein Information
| Protein ID | NP_001264092.1 |
|---|---|
| Protein Name | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| Molecular Wt. (Da) | 19068 |
| Protein Sequence | Download Select all |
| Length | 212 |
| Uniprot ID | P02649 |
| Ensembl Protein ID | ENSP00000252486 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 634 | CEACAM1 | 191 | NP_001703.2 | in vitro | 8018919 |
| 6279 | S100A8 | 471 | NP_002955.2 | in vivo | 11708798 |
| 6714 | SRC | 1819 | NP_005408.1 | in vitro;in vivo | 11708798 |
| 122011 | CSNK1A1L | 13095 | NP_660204.1 | in vitro | 11708798 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05774 | 36-140 | Ig_CEACAM_D1 |
| cl11960 | 36-140 | Ig superfamily |
| cd05741 | 48-140 | Ig_CEACAM_D1_like |
| pfam07686 | 42-140 | V-set |
| cd05734 | 85-124 | Ig7_DSCAM |
| cd00096 | 65-124 | Ig |
| cd04969 | 96-121 | Ig5_Contactin_like |
Ontology Information
| HPRD ID | 135 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.