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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CEACAM5 1048 carcinoembryonic antigen-related cell adhesion molecule 5  19CD66e 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24293105   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Unknown-CEA level may be a suitable biomarker for predicting tumor response to 5-FU-based chemotherapy in CRC.

20799911   2011Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 4509

Stage : -

EndoscopyUp-regulation-The validation study supports the use of the combination of plasma TIMP-1 and CEA protein measurements as a potential aid in early detection of CRC and specifically of CC.


Gene Details



Chromosome 19 - NC_000019.10 (41708611..41730433)

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Gene Type protein coding
Gene Family CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / I-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[  
Chromosome 19
Location 19q13.1-q1
Start 41708611  
End 41730433  
Strand +  
Gene Sequence

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Length 21823  
OMIM ID 114890   
HGNC ID HGNC:1817   
Unigene ID Hs.709196   
Ensembl ID ENSG00000105388   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004363.4
Exon join(1..185,1070..1429,6361..6639,7040..7294,8845..9123, 9518..9772,11320..11598,12312..12566,18624..18742, 20574..21823)  
mRNA Sequence

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Length 3516  



CDS Information


   
Location join(122..185,1070..1429,6361..6639,7040..7294,8845..9123, 9518..9772,11320..11598,12312..12566,18624..18706)
CDS Sequence

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CCDS ID CCDS12584.1



Protein Information


      
Protein IDNP_001278413.1
Protein Namecarcinoembryonic antigen-related cell adhesion molecule 5
Molecular Wt. (Da)71329
Protein Sequence

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Length 702  
Uniprot IDP07203
Ensembl Protein ID ENSP00000391316  



Post-translational Modification Information (Source : HPRD)


Residue Type site
AGlycosyl phosphatidyl inositol GPI676

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2130EWSR1592NP_053733.2yeast 2-hybrid16189514   
57540PTCHD213852NP_065831.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0577436-140  Ig_CEACAM_D1
cl1196036-140  Ig superfamily
cd05740146-234  Ig_CEACAM_D4
cl11960146-234  Ig superfamily
cd05740324-412  Ig_CEACAM_D4
cl11960324-412  Ig superfamily
cd00096433-491  Ig
cl11960433-491  Ig superfamily
cd00096255-313  Ig
cl11960255-313  Ig superfamily
cd05740502-590  Ig_CEACAM_D4
cl11960502-590  Ig superfamily
cd0574148-140  Ig_CEACAM_D1_like
pfam13895239-318  Ig_2
pfam13895418-496  Ig_2
pfam13895596-674  Ig_2
cl11960596-674  Ig superfamily
pfam00047252-301  ig
pfam13927241-303  Ig_3
cd05728422-500  Ig4_Contactin-2-like
cd05850244-303  Ig1_Contactin-2
cd05736434-483  Ig2_Follistatin_like
cd05736256-303  Ig2_Follistatin_like
pfam13927419-481  Ig_3
cd05728244-303  Ig4_Contactin-2-like
cd04967434-482  Ig1_Contactin
cd05728601-659  Ig4_Contactin-2-like
cd04967244-304  Ig1_Contactin
pfam00047608-657  ig
pfam07686252-318  V-set
cd04968600-665  Ig3_Contactin_like
cd00096611-669  Ig
cd04978608-659  Ig4_L1-NrCAM_like
cd05851602-660  Ig3_Contactin-1
cd05848433-482  Ig1_Contactin-5
cd05856428-492  Ig2_FGFRL1-like
cd05850422-481  Ig1_Contactin-2
pfam13927597-659  Ig_3
pfam00047432-479  ig
cd04968244-313  Ig3_Contactin_like
pfam13895146-233  Ig_2
cd05763435-496  Ig_1
cd05729244-311  Ig2_FGFR_like
cd07694601-668  Ig2_CD4
cd05752241-304  Ig1_FcgammaR_like
cd00096163-221  Ig
cd05854432-492  Ig6_Contactin-2
cd05857251-311  Ig2_FGFR
cd05753252-299  Ig2_FcgammaR_like
cd04968415-482  Ig3_Contactin_like
cd05742284-317  Ig1_VEGFR_like
cd05730240-303  Ig3_NCAM-1_like
pfam13895502-589  Ig_2
cd05743519-576  Ig_Perlecan_D2_like
cd05749241-317  Ig2_Tyro3_like
cd05856608-670  Ig2_FGFRL1-like
cd04970253-304  Ig6_Contactin_like
pfam13927502-575  Ig_3
cd05876341-407  Ig3_L1-CAM
pfam00047517-571  ig
smart00410244-318  IG_like
smart00410422-496  IG_like
smart00410513-589  IG_like
smart00408607-659  IGc2
smart00408161-222  IGc2
smart00408339-400  IGc2
smart00409244-318  IG
smart00409422-496  IG
pfam07679241-304  I-set
smart00408251-304  IGc2
smart00408429-484  IGc2
smart00409600-659  IG
smart00410600-659  IG_like
smart00410157-219  IG_like
smart00409157-219  IG
PHA02826434-573  PHA02826
smart00409513-589  IG
pfam07679433-500  I-set
pfam07679161-233  I-set
pfam07679339-398  I-set
smart00409339-411  IG
smart00410339-411  IG_like
pfam07679517-577  I-set
PHA02826106-215  PHA02826
PHA02826350-395  PHA02826
PHA02785200-345  PHA02785
smart00408517-578  IGc2


Ontology Information


   
HPRD ID1119
Molecular ClassAdhesion molecule
Molecular FunctionChemokine activity (GO:0008009)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO