Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CEACAM6 | 4680 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 19 | NCA; CEAL; CD66c |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23027178 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Flow cytometry, immunohistochemistry | Up-regulation | - | CD66c expression was significantly higher in colon cancers than in contiguous normal colon tissues and paralleled cancer stage. CD66c(bright) expression was associated with colon cancer stem cells and CD66c silencing blocked tumor growth, thereby opening the way to a potential new treatment for colon cancer. |
| 22975528 | 2013 | Cell line : - Source : Department of Surgery, Eulji University Hospital (Daejeon, South Korea) Sample Type : CRC tumor and normal tissue No. of Sample : 143 Stage : - | Tissue microarray, RT-PCR and immunohistochemistry | Up-regulation | - | CEACAM6 is significantly upregulated in colon cancer tissues and is closely associated with poor prognosis, indicating that CEACAM6 might be used as a tumor biomarker and a potential therapeutic target for colon cancer |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, Immunoglobulin superfamily / V-set domain containing, Immunoglobulin superfamily / Immunoglobulin-like domain containing |
| Description | Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA (Barnett et al., 1988 [PubMed 3220478]). For background information on the CEA family of genes, see CEACAM1 (MIM 109770).[supplied by OMIM, Mar 2008] | Chromosome | 19 |
| Location | 19q13.2 |
| Start | 41755421 |
| End | 41772211 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16791 |
| OMIM ID | 163980 |
| HGNC ID | HGNC:1818 |
| Unigene ID | Hs.466814 |
| Ensembl ID | ENSG00000086548 |
| PharmGKB ID | PA26362 |
mRNA Information
| mRNA ID | XM_011526990.1 |
|---|---|
| Exon | join(1..282,1180..1539,5829..6107,6549..6803,15382..16791) | mRNA Sequence | Download Select all |
| Length | 2631 |
CDS Information
| Location | join(219..282,1180..1539,5829..6107,6549..6803, 15382..15398) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_002474.4 |
|---|---|
| Protein Name | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| Molecular Wt. (Da) | 33526 |
| Protein Sequence | Download Select all |
| Length | 344 |
| Uniprot ID | P36222 |
| Ensembl Protein ID | ENSP00000255409 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 104 |
| N | Glycosylation | 111 |
| N | Glycosylation | 115 |
| N | Glycosylation | 152 |
| N | Glycosylation | 256 |
| N | Glycosylation | 274 |
| N | Glycosylation | 288 |
| N | Glycosylation | 292 |
| G | Glycosyl phosphatidyl inositol GPI | 320 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 634 | CEACAM1 | 191 | NP_001703.2 | in vitro | 8018919 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05774 | 36-140 | Ig_CEACAM_D1 |
| cl11960 | 36-140 | Ig superfamily |
| cd00096 | 255-313 | Ig |
| cl11960 | 255-313 | Ig superfamily |
| cd05740 | 146-234 | Ig_CEACAM_D4 |
| cl11960 | 146-234 | Ig superfamily |
| cd05741 | 48-140 | Ig_CEACAM_D1_like |
| pfam13895 | 239-318 | Ig_2 |
| pfam00047 | 252-301 | ig |
| pfam13927 | 241-303 | Ig_3 |
| cd05736 | 256-305 | Ig2_Follistatin_like |
| cd05850 | 251-303 | Ig1_Contactin-2 |
| pfam13927 | 146-219 | Ig_3 |
| cd05728 | 173-219 | Ig4_Contactin-2-like |
| cd05728 | 252-303 | Ig4_Contactin-2-like |
| cd00096 | 163-221 | Ig |
| pfam13895 | 146-233 | Ig_2 |
| cd04967 | 257-304 | Ig1_Contactin |
| cd05743 | 163-219 | Ig_Perlecan_D2_like |
| cd05724 | 168-233 | Ig2_Robo |
| pfam00047 | 161-216 | ig |
| cd05751 | 145-233 | Ig1_LILRB1_like |
| cd05729 | 257-311 | Ig2_FGFR_like |
| cd05753 | 252-299 | Ig2_FcgammaR_like |
| cd05752 | 252-305 | Ig1_FcgammaR_like |
| pfam07686 | 41-140 | V-set |
| cd05848 | 257-304 | Ig1_Contactin-5 |
| cd05857 | 252-311 | Ig2_FGFR |
| cd05749 | 241-304 | Ig2_Tyro3_like |
| cd05863 | 257-310 | Ig2_VEGFR-3 |
| cd05752 | 160-233 | Ig1_FcgammaR_like |
| cd00096 | 54-124 | Ig |
| cd05745 | 163-225 | Ig3_Peroxidasin |
| pfam07686 | 251-318 | V-set |
| cd04968 | 252-304 | Ig3_Contactin_like |
| cd04969 | 96-121 | Ig5_Contactin_like |
| cd05748 | 169-233 | Ig_Titin_like |
| cd05850 | 175-220 | Ig1_Contactin-2 |
| cd05856 | 250-311 | Ig2_FGFRL1-like |
| cd04977 | 241-315 | Ig1_NCAM-1_like |
| cd05734 | 85-124 | Ig7_DSCAM |
| cd04970 | 253-305 | Ig6_Contactin_like |
| smart00410 | 244-312 | IG_like |
| smart00410 | 157-233 | IG_like |
| smart00409 | 244-312 | IG |
| pfam07679 | 241-305 | I-set |
| smart00408 | 251-305 | IGc2 |
| pfam07679 | 161-233 | I-set |
| smart00409 | 157-233 | IG |
| smart00408 | 161-222 | IGc2 |
| PHA02826 | 106-217 | PHA02826 |
Ontology Information
| HPRD ID | 8351 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Phospholipase activity (GO:0004620) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.