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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12839935 | 2003 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 11 Stage : Duke Stage B,C,D | Immunoblotting,Immunohistochemistry,RT-PCR and Real Time RT- PCR,FISH . | Up-regulation | - | Overexpression of CENP-A could play an important role for aneuploidy in colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] | Chromosome | 2 |
| Location | 2p23.3 |
| Start | 27008857 |
| End | 27023935 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 15079 |
| OMIM ID | 117139 |
| HGNC ID | HGNC:1851 |
| Unigene ID | Hs.1594 |
| Ensembl ID | ENSG00000115163 |
| PharmGKB ID | PA26396 |
mRNA Information
| mRNA ID | NM_001809.3 |
|---|---|
| Exon | join(1..283,6118..6227,6743..6820,7132..7313,7799..8576) | mRNA Sequence | Download Select all |
| Length | 1431 |
Protein Information
| Protein ID | NP_001800.1 |
|---|---|
| Protein Name | centromere protein A |
| Molecular Wt. (Da) | 15859 |
| Protein Sequence | Download Select all |
| Length | 140 |
| Uniprot ID | Q92823 |
| Ensembl Protein ID | ENSP00000325269 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 7 |
| S | Phosphorylation | 17;- |
| S | Phosphorylation | 19;- |
| S | Phosphorylation | 17;- |
| S | Phosphorylation | 19;- |
| T | Phosphorylation | 23;- |
| T | Phosphorylation | 23;- |
| S | Phosphorylation | 27 |
| S | Phosphorylation | 27 |
| T | Phosphorylation | 21 |
| T | Phosphorylation | 21 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1729 | DIAPH1 | 3670 | NP_005210.3 | yeast 2-hybrid | 15085137 |
| 1730 | DIAPH2 | 2117 | NP_006720.1 | in vivo;yeast 2-hybrid | 15085137 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PLN00161 | 3-134 | PLN00161 |
| cl00074 | 3-134 | H2A superfamily |
| PLN00160 | 42-134 | PLN00160 |
| pfam00125 | 57-133 | Histone |
| COG2036 | 48-134 | HHT1 |
| smart00428 | 34-137 | H3 |
| PTZ00018 | 5-134 | PTZ00018 |
| PLN00121 | 5-134 | PLN00121 |
Ontology Information
| HPRD ID | 552 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Hydrolase activity (GO:0016787) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.