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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CFB | 629 | Complement factor B | 6 | BF; FB; BFD; GBG; CFAB; PBF2; AHUS4; FBI12; H2-Bf |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22799385 | 2012 | Cell line : - Source : Department of Gastrointestinal Surgery, Guangdong Provincial People Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 13 Stage : - | 2-D Gelelectrophoresis and MALDI-TOF mass spectrometry | Down-regulation | - | This Gene differentially expressed and analysed by 2-D Gel Electrophoresis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Complement system |
| Description | This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 31945944 |
| End | 31952084 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6141 |
| OMIM ID | 138470 |
| HGNC ID | HGNC:1037 |
| Unigene ID | Hs.69771 |
| Ensembl ID | ENSG00000243649 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001710.5 |
|---|---|
| Exon | join(1..342,430..663,1064..1249,1405..1578,1799..1900, 2002..2138,2431..2569,2887..3018,3300..3401,3477..3614, 4107..4204,4343..4460,4676..4829,4925..5001,5201..5301, 5398..5530,5612..5661,5932..6141) | mRNA Sequence | Download Select all |
| Length | 2646 |
CDS Information
| Location | join(279..342,430..663,1064..1249,1405..1578,1799..1900, 2002..2138,2431..2569,2887..3018,3300..3401,3477..3614, 4107..4204,4343..4460,4676..4829,4925..5001,5201..5301, 5398..5530,5612..5661,5932..6087) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4729.1 |
Protein Information
| Protein ID | NP_001701.2 |
|---|---|
| Protein Name | Complement factor B |
| Molecular Wt. (Da) | 83001 |
| Protein Sequence | Download Select all |
| Length | 764 |
| Uniprot ID | P30837 |
| Ensembl Protein ID | ENSP00000366927 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 285 |
| K | Glycation | 291 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 0 | C4B | 402 | NP_000583.2 | in vitro | 11341920 |
| 718 | C3 | 400 | NP_000055.2 | in vitro | 10 610 782 864 813 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Staphylococcus aureus infection | hsa05150 |
Structure Information
| PDB ID | 1DLE |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | COMPLEMENT FACTOR B |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01470 | 269-466 | vWA_complement_factors |
| cl00057 | 269-466 | vWFA superfamily |
| cd00190 | 488-755 | Tryp_SPc |
| cl21584 | 488-755 | Tryp_SPc superfamily |
| cd00033 | 103-158 | CCP |
| cl00043 | 103-158 | CCP superfamily |
| cd00033 | 165-219 | CCP |
| cl00043 | 165-219 | CCP superfamily |
| cd01450 | 269-453 | vWFA_subfamily_ECM |
| pfam00092 | 270-468 | VWA |
| smart00327 | 270-463 | VWA |
| cd00198 | 270-453 | vWFA |
| smart00032 | 103-158 | CCP |
| smart00032 | 165-218 | CCP |
| pfam00084 | 103-158 | Sushi |
| cd01469 | 269-464 | vWA_integrins_alpha_subunit |
| cd01471 | 269-435 | vWA_micronemal_protein |
| cd01472 | 270-390 | vWA_collagen |
| cd01480 | 267-450 | vWA_collagen_alpha_1-VI-type |
| pfam00084 | 165-218 | Sushi |
| cd01482 | 271-457 | vWA_collagen_alphaI-XII-like |
| pfam13519 | 261-445 | VWA_2 |
| smart00032 | 55-83 | CCP |
| cl00043 | 55-83 | CCP superfamily |
| COG3591 | 488-609 | eMpr |
| pfam00089 | 491-752 | Trypsin |
| smart00020 | 488-721 | Tryp_SPc |
| PHA02927 | 55-218 | PHA02927 |
| PHA02927 | 55-219 | PHA02927 |
| PHA02817 | 98-218 | PHA02817 |
| PHA02831 | 50-218 | PHA02831 |
| PHA02639 | 55-218 | PHA02639 |
| PHA02639 | 99-219 | PHA02639 |
| COG5640 | 502-720 | COG5640 |
| PHA02954 | 89-218 | PHA02954 |
| PHA02817 | 75-158 | PHA02817 |
Ontology Information
| HPRD ID | 5 |
|---|---|
| Molecular Class | Complement protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.