Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHD2 | 1106 | chromodomain helicase DNA binding protein 2  | 15 | FLJ38614, DKFZp547I1315, DKFZp781D1727, DKFZp686E01200  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21447119    | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 28 gastric cancers with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS Stage : - | Immunohistochemistry,MSI-L/MSS by SSCP | Frameshift Mutation | - | Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   | Chromosome | 15 |
| Location | 15q26 |
| Start | 93442286   |
| End | 93571237   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 128952   |
| OMIM ID | 602119    |
| HGNC ID | HGNC:1917    |
| Unigene ID | Hs.220864    |
| Ensembl ID | ENSG00000173575    |
| PharmGKB ID | PA26453    |
mRNA Information
| mRNA ID | NM_001271.3 |
|---|---|
| Exon | join(1..504,847..979,24001..24232,26924..27010, 28710..28771,37198..37305,39258..39398,41502..41635, 42523..42748,44095..44195,45501..45545,45718..45896, 48632..48756,53037..53253,55103..55192,56139..56329, 67005..67193,71445..71607,71945..72097,74559..74630, 77914..78063,78815..78963,80495..80591,81045..81137, 84010..84180,85178..85353,91156..91197,92539..92678, 96637..96775,96933..97083,98179..98301,100192..100320, 101857..101997,104297..104431,108825..109003, 112025..112124,114376..114589,119692..119938, 124052..127687)   | mRNA Sequence |    Download   Select all |
| Length | 9374   |
CDS Information
| Location | 576..6062 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10374.2 |    
Protein Information
| Protein ID | NP_001262.3 |
|---|---|
| Protein Name | chromodomain helicase DNA binding protein 2 |
| Molecular Wt. (Da) | 211213 |
| Protein Sequence |    Download   Select all |
| Length | 1828   |
| Uniprot ID | P04629 |    
| Ensembl Protein ID | ENSP00000357179   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 125 |
| K | Sumoylation | 623 |
| K | Sumoylation | 702 |
| K | Sumoylation | 842 |
| K | Sumoylation | 1285 |
| K | Sumoylation | 1347 |
| K | Sumoylation | 1356 |
| K | Sumoylation | 1379 |
| K | Sumoylation | 125 |
| T | Phosphorylation | 240 |
| S | Phosphorylation | 242 |
| T | Phosphorylation | 240 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 207 |
| S | Phosphorylation | 208 |
| S | Phosphorylation | 207 |
| S | Phosphorylation | 208 |
| S | Phosphorylation | 1364 |
| S | Phosphorylation | 1012 |
| S | Phosphorylation | 747 |
| S | Phosphorylation | 1441 |
| T | Phosphorylation | 164 |
| T | Phosphorylation | 164 |
| S | Phosphorylation | 1386 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00079 | 789-913  | HELICc |
| cl21455 | 789-913  | P-loop_NTPase superfamily |
| cd00046 | 503-648  | DEXDc |
| cl21455 | 503-648  | P-loop_NTPase superfamily |
| cd00024 | 282-344  | CHROMO |
| cl17459 | 282-344  | CHROMO superfamily |
| cd00024 | 402-447  | CHROMO |
| cl17459 | 402-447  | CHROMO superfamily |
| pfam13907 | 1468-1555  | DUF4208 |
| cl16467 | 1468-1555  | DUF4208 superfamily |
| smart00490 | 821-905  | HELICc |
| pfam00271 | 825-905  | Helicase_C |
| pfam00385 | 378-447  | Chromo |
| smart00298 | 300-346  | CHROMO |
| pfam00385 | 263-344  | Chromo |
| smart00298 | 380-449  | CHROMO |
| pfam04851 | 481-648  | ResIII |
| pfam00176 | 487-768  | SNF2_N |
| PLN03142 | 468-1021  | PLN03142 |
| COG0553 | 483-957  | HepA |
| smart00487 | 482-667  | DEXDc |
| COG1061 | 480-928  | SSL2 |
| pfam11496 | 721-932  | HDA2-3 |
| COG1111 | 476-987  | MPH1 |
| COG0513 | 790-905  | SrmB |
| TIGR04095 | 480-648  | dnd_restrict_1 |
Ontology Information
| HPRD ID | 3822 |    
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
