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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CHD2 1106 chromodomain helicase DNA binding protein 2  15FLJ38614, DKFZp547I1315, DKFZp781D1727, DKFZp686E01200 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21447119   2011Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 28 gastric cancers with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS

Stage : -

Immunohistochemistry,MSI-L/MSS by SSCP Frameshift Mutation-Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H.


Gene Details



NC_000015.9 (93442286..93571237)

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Gene Type protein coding
Gene Family -
Description The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q26
Start 93442286  
End 93571237  
Strand +  
Gene Sequence

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Length 128952  
OMIM ID 602119   
HGNC ID HGNC:1917   
Unigene ID Hs.220864   
Ensembl ID ENSG00000173575   
PharmGKB ID PA26453   

mRNA Information


mRNA ID NM_001271.3
Exon join(1..504,847..979,24001..24232,26924..27010, 28710..28771,37198..37305,39258..39398,41502..41635, 42523..42748,44095..44195,45501..45545,45718..45896, 48632..48756,53037..53253,55103..55192,56139..56329, 67005..67193,71445..71607,71945..72097,74559..74630, 77914..78063,78815..78963,80495..80591,81045..81137, 84010..84180,85178..85353,91156..91197,92539..92678, 96637..96775,96933..97083,98179..98301,100192..100320, 101857..101997,104297..104431,108825..109003, 112025..112124,114376..114589,119692..119938, 124052..127687)  
mRNA Sequence

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Length 9374  



CDS Information


   
Location 576..6062
CDS Sequence

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CCDS ID CCDS10374.2



Protein Information


      
Protein IDNP_001262.3
Protein Namechromodomain helicase DNA binding protein 2
Molecular Wt. (Da)211213
Protein Sequence

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Length 1828  
Uniprot IDP04629
Ensembl Protein ID ENSP00000357179  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation125
KSumoylation623
KSumoylation702
KSumoylation842
KSumoylation1285
KSumoylation1347
KSumoylation1356
KSumoylation1379
KSumoylation125
TPhosphorylation240
SPhosphorylation242
TPhosphorylation240
SPhosphorylation242
SPhosphorylation207
SPhosphorylation208
SPhosphorylation207
SPhosphorylation208
SPhosphorylation1364
SPhosphorylation1012
SPhosphorylation747
SPhosphorylation1441
TPhosphorylation164
TPhosphorylation164
SPhosphorylation1386

Enzyme Information


No matching records could be found.

PPi Information


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No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00079789-913  HELICc
cl21455789-913  P-loop_NTPase superfamily
cd00046503-648  DEXDc
cl21455503-648  P-loop_NTPase superfamily
cd00024282-344  CHROMO
cl17459282-344  CHROMO superfamily
cd00024402-447  CHROMO
cl17459402-447  CHROMO superfamily
pfam139071468-1555  DUF4208
cl164671468-1555  DUF4208 superfamily
smart00490821-905  HELICc
pfam00271825-905  Helicase_C
pfam00385378-447  Chromo
smart00298300-346  CHROMO
pfam00385263-344  Chromo
smart00298380-449  CHROMO
pfam04851481-648  ResIII
pfam00176487-768  SNF2_N
PLN03142468-1021  PLN03142
COG0553483-957  HepA
smart00487482-667  DEXDc
COG1061480-928  SSL2
pfam11496721-932  HDA2-3
COG1111476-987  MPH1
COG0513790-905  SrmB
TIGR04095480-648  dnd_restrict_1


Ontology Information


   
HPRD ID3822
Molecular ClassDNA binding protein
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO