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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CHD7 55636 chromodomain helicase DNA binding protein 7  8KIAA1416, FLJ20357, FLJ20361 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21447119   2011Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 29 gastric cancers (GCs) with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS.

Stage : -

SSCP, immunohistochemistry Loss of expression mutation-Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H.


Gene Details



NC_000008.10 (61591321..61780587)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]  
Chromosome 8
Location 8q12.2
Start 61591321  
End 61780587  
Strand +  
Gene Sequence

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Length 189267  
OMIM ID 608892   
HGNC ID HGNC:20626   
Unigene ID Hs.20395   
Ensembl ID -   
PharmGKB ID PA134948695   

mRNA Information


mRNA ID ?NM_001316690.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS47865.1



Protein Information


      
Protein IDNP_001303619.1
Protein Namechromodomain helicase DNA binding protein 7
Molecular Wt. (Da)0
Protein Sequence

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Length 2997  
Uniprot IDQ9H3R1
Ensembl Protein ID ENSP00000264363  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2254;-
SPhosphorylation2255;-
SPhosphorylation2141
TPhosphorylation2153
TPhosphorylation2350
SPhosphorylation2356
SPhosphorylation2533
TPhosphorylation2551
SPhosphorylation2559
TPhosphorylation2965
SPhosphorylation1874
SPhosphorylation2956
SPhosphorylation2961
TPhosphorylation786
SPhosphorylation2272
SPhosphorylation2275
SPhosphorylation2969
SPhosphorylation2983
SPhosphorylation725
TPhosphorylation730
SPhosphorylation734
SPhosphorylation637
SPhosphorylation708
SPhosphorylation1577
SPhosphorylation1581
SPhosphorylation1793
SPhosphorylation2251
SPhosphorylation2277
SPhosphorylation2395
TPhosphorylation2472
SPhosphorylation2619
TPhosphorylation1635

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000791290-1412  HELICc
cl214551290-1412  P-loop_NTPase superfamily
cd00046987-1136  DEXDc
cl21455987-1136  P-loop_NTPase superfamily
cd00024883-934  CHROMO
cl17459883-934  CHROMO superfamily
cd00024801-862  CHROMO
cl17459801-862  CHROMO superfamily
smart004901320-1404  HELICc
pfam002711324-1404  Helicase_C
smart005922642-2686  BRK
cl026882642-2686  BRK superfamily
pfam075332640-2684  BRK
pfam075332563-2604  BRK
cl026882563-2604  BRK superfamily
smart005922564-2604  BRK
pfam00385883-935  Chromo
pfam00385800-862  Chromo
smart00298801-863  CHROMO
smart00298883-934  CHROMO
pfam08430306-423  Fork_head_N
cl22540306-423  Fork_head_N superfamily
pfam00270969-1136  DEAD
pfam12533495-569  Neuro_bHLH
cl13910495-569  Neuro_bHLH superfamily
pfam00176971-1258  SNF2_N
PLN03142967-1566  PLN03142
COG0553847-1467  HepA
smart00487961-1159  DEXDc
pfam09606202-576  Med15
pfam0315729-572  Glutenin_hmw
pfam09770265-568  PAT1
pfam0960615-398  Med15
pfam09770364-642  PAT1
pfam03154207-576  Atrophin-1
pfam09606374-576  Med15
pfam07223235-561  DUF1421
COG1203922-1197  Cas3
pfam07223355-586  DUF1421
pfam0315729-561  Glutenin_hmw
TIGR01628446-577  PABP-1234
pfam07223171-426  DUF1421
pfam15258258-580  FAM222A
pfam0977067-314  PAT1
pfam07271447-558  Cytadhesin_P30
pfam09606354-570  Med15
pfam0722347-367  DUF1421
pfam03154241-561  Atrophin-1
pfam0315722-405  Glutenin_hmw
COG5068201-409  ARG80
pfam04503337-544  SSDP
smart00818491-572  Amelogenin
pfam03153221-409  TFIIA
pfam15240456-552  Pro-rich
smart00818489-544  Amelogenin
pfam15240446-561  Pro-rich
pfam04487288-413  CITED
pfam02948491-570  Amelogenin
pfam15258180-427  FAM222A
PHA03377391-568  PHA03377
pfam02948492-585  Amelogenin
TIGR01628409-545  PABP-1234


Ontology Information


   
HPRD ID6901
Molecular ClassDNA binding protein
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO