Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 12 | RNF116; RNF196 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21551253 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 82 Stage : Stage II , III | Pyrosequencing | Methylation | - | The extent of CHFR promoter methylation correlates with RFS, indicating it is a promising epigenetic marker for recurrence. |
| 24928946 | 2014 | Cell line : - Source : Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : 173 Stage : Stage I-IV | - | Methylation | - | CHFR promoter CpG island methylation, which is associated with MSI, also occurs frequently in MSS CRCs and is a promising prognostic marker in stage II, MSS, BRAF WT CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ring finger proteins |
| Description | This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014] | Chromosome | 12 |
| Location | 12q24.33 |
| Start | 133416937 |
| End | 133481459 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 64523 |
| OMIM ID | 605209 |
| HGNC ID | HGNC:20455 |
| Unigene ID | Hs.720197 |
| Ensembl ID | ENSG00000072609 |
| PharmGKB ID | PA134898949 |
Protein Information
| Protein ID | NP_001154816.1 |
|---|---|
| Protein Name | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 664 |
| Uniprot ID | Q70SY1 |
| Ensembl Protein ID | ENSP00000329140 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| I | Ubiquitination | 306 |
| W | Ubiquitination | 332 |
| I | Ubiquitination | 265 |
| W | Ubiquitination | 291 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5371 | PML | 23 | NP_150241.2 | in vitro;in vivo | 15467728 |
| 6790 | AURKA | 4066 | NP_003591.2 | in vitro;in vivo | 15793587 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00060 | 16-105 | FHA |
| cl00062 | 16-105 | FHA superfamily |
| cd00162 | 303-346 | RING |
| cl17238 | 303-346 | RING superfamily |
| pfam00498 | 38-105 | FHA |
| pfam13923 | 304-342 | zf-C3HC4_2 |
| pfam13639 | 303-343 | zf-RING_2 |
| smart00184 | 304-342 | RING |
| pfam00097 | 304-342 | zf-C3HC4 |
| pfam13920 | 300-349 | zf-C3HC4_3 |
| pfam14835 | 296-345 | zf-RING_6 |
| TIGR00599 | 298-502 | rad18 |
| COG1716 | 31-140 | FHA |
| TIGR03354 | 31-105 | VI_FHA |
| COG5432 | 298-446 | RAD18 |
| COG5243 | 303-346 | HRD1 |
| COG3456 | 32-199 | COG3456 |
| pfam12678 | 303-343 | zf-rbx1 |
Ontology Information
| HPRD ID | 12029 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.