Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHI3L1 | 1116 | chitinase 3-like 1 (cartilage glycoprotein-39) | 1 | GP39, YKL40 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22056877 | 2012 | Cell line : - Source : Kyoto University Hospital Sample Type : CRC tumor and Normal tissue No. of Sample : 61 Stage : TNM stage I-IV | real time RT-PCR, Western blotting, ELISA, immunohistochemistry | Up-regulation | - | Inhibition of CHI3L1 activity may be a novel therapeutic strategy for human colorectal cancer. CHI3L1 expressed in colon cancer cells promotes cancer cell proliferation, macrophage recruitment and angiogenesis. Plasma protein and tissue mRNA expression levels of CHI3L1 in colorectal cancer were strongly upregulated |
| 24996799 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 86 CRC and 20 healthy controls Stage : TNM stage I-IV | - | Up-regulation | - | The pretreatment serum YKL-40 level was identified as a new, independent prognostic biomarker in patients with colorectal cancer and may help to determine the individual prognosis of these patients. Expression of serum YKL-40 levels was significantly higher in colorectal cancer patients compared with healthy controls. |
| 24498368 | 2014 | Cell line : - Source : NORDIC VII Study Sample Type : - No. of Sample : 510 CRC patient and 3130 healthy control Stage : - | ELISA | Up-regulation | - | Plasma YKL-40 is an independent prognostic biomarker in patients with mCRC treated with first-line oxaliplatin-based therapy alone or combined with cetuximab. Pretreatment plasma YKL-40 was elevated in 204 patients (40%), and median YKL-40 was higher in patients with mCRC than in healthy subjects (age adjusted, P<0.001). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. | Chromosome | 1 |
| Location | 1q32.1 |
| Start | 203178931 |
| End | 203186960 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8030 |
| OMIM ID | 601525 |
| HGNC ID | HGNC:1932 |
| Unigene ID | Hs.382202 |
| Ensembl ID | ENSG00000133048 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011509108.1 |
|---|---|
| Exon | join(1..362,616..645,1576..1777,2329..2385,3152..3320, 4109..4230,5676..5799,7084..7200,7376..8030) | mRNA Sequence | Download Select all |
| Length | 1867 |
CDS Information
| Location | join(338..362,616..645,1576..1777,2329..2385,3170..3320, 4109..4230,5676..5799,6309..6491,7084..7200,7376..7516) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1435.1 |
Protein Information
| Protein ID | NP_001267.2 |
|---|---|
| Protein Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
| Molecular Wt. (Da) | 40489 |
| Protein Sequence | Download Select all |
| Length | 383 |
| Uniprot ID | P36969 |
| Ensembl Protein ID | ENSP00000346103 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02872 | 24-380 | GH18_chitolectin_chitotriosidase |
| cl10447 | 24-380 | GH18_chitinase-like superfamily |
| cd06548 | 25-357 | GH18_chitinase |
| cd02873 | 23-380 | GH18_IDGF |
| cd02879 | 27-358 | GH18_plant_chitinase_class_V |
| cd00598 | 24-207 | GH18_chitinase-like |
| cd02878 | 23-357 | GH18_zymocin_alpha |
| cd02874 | 89-358 | GH18_CFLE_spore_hydrolase |
| cd02875 | 111-361 | GH18_chitobiase |
| cd02876 | 83-280 | GH18_SI-CLP |
| cd06545 | 52-266 | GH18_3CO4_chitinase |
| cd06549 | 64-262 | GH18_trifunctional |
| cd06544 | 83-165 | GH18_narbonin |
| cd02871 | 91-161 | GH18_chitinase_D-like |
| PRK05910 | 154-204 | PRK05910 |
| cl07980 | 154-204 | FHIPEP superfamily |
| smart00636 | 23-357 | Glyco_18 |
| pfam00704 | 22-357 | Glyco_hydro_18 |
| COG3325 | 21-383 | ChiA |
| COG3858 | 80-358 | YaaH |
Ontology Information
| HPRD ID | 5418 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.