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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16424007 | 2006 | Cell line : - Source : Early Detection Research Network of the University of Pittsburgh Medical Center. Sample Type : CRC tumor and normal tissue No. of Sample : Colon adenocarcinoma samples and matched adjacent normal tissues (n = 9), normal colon tissue (n = 10) from donors, liver tumors from metastatic,colorectal cancer (n = 4), normal unaffected liver from the same subject, and normal livers from donors (n = 3) Stage : TNM Stage I-IV | 2D Gel Electrophoresis,SDS-PAGE and Immunoblotting,Mass Spectrometry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 14 |
| Location | 14q32.32 |
| Start | 103985995 |
| End | 103989196 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3202 |
| OMIM ID | 123280 |
| HGNC ID | HGNC:1991 |
| Unigene ID | Hs.173724 |
| Ensembl ID | ENSG00000166165 |
| PharmGKB ID | PA26528 |
mRNA Information
| mRNA ID | NM_001823.4 |
|---|---|
| Exon | join(1..94,355..559,683..837,910..1042,1426..1597, 2268..2391,2549..2738,2818..3202) | mRNA Sequence | Download Select all |
| Length | 1475 |
Protein Information
| Protein ID | NP_001814.2 |
|---|---|
| Protein Name | creatine kinase, brain |
| Molecular Wt. (Da) | 42513 |
| Protein Sequence | Download Select all |
| Length | 381 |
| Uniprot ID | Q16832 |
| Ensembl Protein ID | ENSP00000356898 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 35 |
| S | Phosphorylation | 199 |
| S | Phosphorylation | 4 |
| C | S-Nitrosylation | 254 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 140462 | ASB9 | 6452 | AAH13172.1 | yeast 2-hybrid | 16189514 |
| 387923 | SERP2 | 16590 | NP_001010897.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arginine and proline metabolism | hsa00330 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00716 | 16-373 | creatine_kinase_like |
| cl02823 | 16-373 | phosphagen_kinases superfamily |
| cd07931 | 23-366 | eukaryotic_phosphagen_kinases |
| pfam00217 | 120-367 | ATP-gua_Ptrans |
| cd00330 | 126-366 | phosphagen_kinases |
| cd07932 | 17-367 | arginine_kinase_like |
| pfam02807 | 21-100 | ATP-gua_PtransN |
| cl03723 | 21-100 | ATP-gua_PtransN superfamily |
| cd07930 | 126-366 | bacterial_phosphagen_kinase |
| PRK01059 | 118-364 | PRK01059 |
| COG3869 | 118-364 | McsB |
Ontology Information
| HPRD ID | 3974 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P12277 | DB00148 | Creatine | SmallMoleculeDrug |