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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CLCA1 | 1179 | Chloride channel, calcium activated, family member 1 | 1 | CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11445004 | 2001 | Cell line : T 84, HT 29,Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, | Down-regulation | - | CLCA1 and CLCA2, was significantly downregulated in approximately 80% of colorectal carcinomas. |
| 14988065 | 2004 | Cell line : Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR and Western blotting, Flow cytometry, Short-circuit current measurements and Patch-clamp | Down-regulation | - | pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line. pCLCA1 may function chiefly as a modulator of endogenous Cl conductance channels. |
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wroc$aw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Down-regulation | 0.031 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p22.3 |
| Start | 86468843 |
| End | 86500294 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31452 |
| OMIM ID | 603906 |
| HGNC ID | HGNC:2015 |
| Unigene ID | Hs.194659 |
| Ensembl ID | ENSG00000016490 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001285.3 |
|---|---|
| Exon | join(1..291,4575..4715,4887..5034,7606..7711,13363..13540, 16501..16719,17684..17911,20154..20328,22423..22529, 24542..24757,25345..25606,26663..26833,29730..29969, 30812..31452) | mRNA Sequence | Download Select all |
| Length | 3123 |
CDS Information
| Location | join(130..291,4575..4715,4887..5034,7606..7711, 13363..13540,16501..16719,17684..17911,20154..20328, 22423..22529,24542..24757,25345..25606,26663..26833, 29730..29969,30812..31203) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS709.1 |
Protein Information
| Protein ID | NP_001276.2 |
|---|---|
| Protein Name | Chloride channel, calcium activated, family member 1 |
| Molecular Wt. (Da) | 98005 |
| Protein Sequence | Download Select all |
| Length | 914 |
| Uniprot ID | P05067 |
| Ensembl Protein ID | ENSP00000284981 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pancreatic secretion | hsa04972 |
| Renin secretion | hsa04924 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00198 | 305-458 | vWFA |
| cl00057 | 305-458 | vWFA superfamily |
| pfam08434 | 1-261 | CLCA_N |
| cl07163 | 1-261 | CLCA_N superfamily |
| pfam09315 | 486-660 | DUF1973 |
| cl09605 | 486-660 | DUF1973 superfamily |
| smart00327 | 307-464 | VWA |
| pfam13519 | 307-471 | VWA_2 |
| COG4245 | 307-490 | TerY |
| cd01464 | 307-452 | vWA_subfamily |
| cd01465 | 308-438 | vWA_subgroup |
| cd01466 | 306-458 | vWA_C3HC4_type |
| cd01467 | 307-462 | vWA_BatA_type |
| cd01461 | 307-461 | vWA_interalpha_trypsin_inhibitor |
| pfam00092 | 307-458 | VWA |
| cd01451 | 305-416 | vWA_Magnesium_chelatase |
| cd01471 | 307-438 | vWA_micronemal_protein |
| cd01462 | 303-442 | VWA_YIEM_type |
| cd01456 | 307-465 | vWA_ywmD_type |
| cd01450 | 309-449 | vWFA_subfamily_ECM |
| cd01474 | 309-476 | vWA_ATR |
| TIGR00868 | 1-861 | hCaCC |
| COG1240 | 307-416 | ChlD |
| TIGR03436 | 309-472 | acidobact_VWFA |
| TIGR02442 | 307-420 | Cob-chelat-sub |
Ontology Information
| HPRD ID | 100 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.