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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24479816 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : Colon cancer (CC) patients and in a control population of healthy blood donors. 102 formalin fixed paraffin embedded (FFPE) colon cancer tissue, and 111 blood leukocyte DNA from blood/plasma donors Stage : TNM Stage I-IV | Pyrosequencing | Polymorhpism | - | The CLDN1 rs9869263 genotype (c.369C>T) was related to increased risk of colon cancer, and the CLDN7 rs4562 genotype (c.590C>T) was related to tumor differentiation and lymph node involvement in colon carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Claudins |
| Description | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] | Chromosome | 17 |
| Location | 17p13.1 |
| Start | 7163222 |
| End | 7166863 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3642 |
| OMIM ID | 609131 |
| HGNC ID | HGNC:2049 |
| Unigene ID | Hs.513915 |
| Ensembl ID | ENSG00000181885 |
| PharmGKB ID | PA26575 |
mRNA Information
| mRNA ID | NM_203415.1 |
|---|---|
| Exon | complement(<3254..>3291) | mRNA Sequence | Download Select all |
| Length | 1322 |
Protein Information
| Protein ID | NP_981960.1 |
|---|---|
| Protein Name | claudin 7 |
| Molecular Wt. (Da) | 34710 |
| Protein Sequence | Download Select all |
| Length | 316 |
| Uniprot ID | P01127 |
| Ensembl Protein ID | ENSP00000330382 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7082 | TJP1 | 3002 | NP_003248.3 | in vitro | 10601346 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Hepatitis C | hsa05160 |
| Leukocyte transendothelial migration | hsa04670 |
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00822 | 4-182 | PMP22_Claudin |
| cl21598 | 4-182 | Claudin_2 superfamily |
| pfam13903 | 15-183 | Claudin_2 |
Ontology Information
| HPRD ID | 1423 |
|---|---|
| Molecular Class | Cell junction protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.