Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CLIC1 | 1192 | chloride intracellular channel 1 | 6 | NCC27, p64CLCP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18710659 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 6 Stage : - | - | Up-regulation | 3 Fold | CLIC1 and TPD52 were significantly (P<0.05) up-regulated in all cases of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Chloride channels : Intracellular |
| Description | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 31698358 |
| End | 31705095 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6738 |
| OMIM ID | 602872 |
| HGNC ID | HGNC:2062 |
| Unigene ID | Hs.414565 |
| Ensembl ID | ENSG00000213719 |
| PharmGKB ID | PA26588 |
mRNA Information
| mRNA ID | NM_001287593.1 |
|---|---|
| Exon | join(1..523,969..1057,3056..3165,3358..3483,3647..3753, 4921..5102,6316..6738) | mRNA Sequence | Download Select all |
| Length | 1574 |
Protein Information
| Protein ID | NP_001274522.1 |
|---|---|
| Protein Name | chloride intracellular channel 1 |
| Molecular Wt. (Da) | 26792 |
| Protein Sequence | Download Select all |
| Length | 241 |
| Uniprot ID | P52948 |
| Ensembl Protein ID | ENSP00000316032 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 163 |
| K | Acetylation | 119 |
| K | Acetylation | 131 |
| K | Acetylation | 135 |
| K | Acetylation | 13 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6399 | TRAPPC2 | 2189 | NP_055378.1 | in vivo | 12681486 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10300 | 100-238 | GST_C_CLIC1 |
| cl02776 | 100-238 | GST_C_family superfamily |
| cd03061 | Mar-93 | GST_N_CLIC |
| cl00388 | Mar-93 | Thioredoxin_like superfamily |
| cd10296 | 100-240 | GST_C_CLIC4 |
| cd10297 | 100-240 | GST_C_CLIC5 |
| cd10301 | 100-238 | GST_C_CLIC6 |
| cd10298 | 100-238 | GST_C_CLIC2 |
| cd03198 | 100-234 | GST_C_CLIC |
| cd10299 | 101-233 | GST_C_CLIC3 |
| cd03201 | 101-229 | GST_C_DHAR |
| pfam13409 | 24-86 | GST_N_2 |
| cd00570 | 23-85 | GST_N_family |
| pfam13417 | 24-86 | GST_N_3 |
| pfam13410 | 159-210 | GST_C_2 |
| cd00299 | 80-210 | GST_C_family |
| cd03059 | 23-85 | GST_N_SspA |
| cd03054 | Aug-86 | GST_N_Metaxin |
| pfam00043 | 127-217 | GST_C |
| cd03186 | 124-219 | GST_C_SspA |
| TIGR00862 | 6-241 | O-ClC |
| PLN02817 | 20-229 | PLN02817 |
| PLN02378 | 8-229 | PLN02378 |
| COG0435 | 150-233 | ECM4 |
Ontology Information
| HPRD ID | 3582 |
|---|---|
| Molecular Class | Intracellular ligand gated channel |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.