Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CLIC4 | 25932 | chloride intracellular channel 4 | 1 | DKFZP566G223, CLIC4L, P64H1, H1, huH1, p64H1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24916695 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : Stage I-IV | Immunohistochemistry | Unknown | - | CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Chloride channels : Intracellular |
| Description | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p |
| Start | 25071760 |
| End | 25170815 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 99056 |
| OMIM ID | 606536 |
| HGNC ID | HGNC:13518 |
| Unigene ID | Hs.440544 |
| Ensembl ID | ENSG00000169504 |
| PharmGKB ID | PA26591 |
Protein Information
| Protein ID | NP_039234.1 |
|---|---|
| Protein Name | chloride intracellular channel 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 253 |
| Uniprot ID | Q8TAV3 |
| Ensembl Protein ID | ENSP00000310149 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | S-Nitrosylation | 234 |
| K | Acetylation | 130 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vivo | 11563969 |
| 1759 | DNM1 | 3851 | NP_004399.2 | in vitro | 11563969 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vitro | 11563969 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10296 | 111-251 | GST_C_CLIC4 |
| cl02776 | 111-251 | GST_C_family superfamily |
| cd03061 | 14-104 | GST_N_CLIC |
| cl00388 | 14-104 | Thioredoxin_like superfamily |
| cd10297 | 111-251 | GST_C_CLIC5 |
| cd10301 | 111-250 | GST_C_CLIC6 |
| cd10300 | 111-249 | GST_C_CLIC1 |
| cd10298 | 111-249 | GST_C_CLIC2 |
| cd03198 | 111-245 | GST_C_CLIC |
| cd10299 | 111-245 | GST_C_CLIC3 |
| cd03201 | 112-240 | GST_C_DHAR |
| pfam13409 | 35-97 | GST_N_2 |
| cd00570 | 34-96 | GST_N_family |
| pfam13417 | 35-97 | GST_N_3 |
| cd03060 | 35-96 | GST_N_Omega_like |
| cd03059 | 34-97 | GST_N_SspA |
| cd00299 | 88-209 | GST_C_family |
| pfam13410 | 134-221 | GST_C_2 |
| pfam00043 | 116-193 | GST_C |
| pfam14497 | 132-221 | GST_C_3 |
| cd03055 | 35-64 | GST_N_Omega |
| TIGR00862 | 17-252 | O-ClC |
| PLN02817 | 16-233 | PLN02817 |
| PLN02378 | 19-240 | PLN02378 |
| PRK15113 | 36-113 | PRK15113 |
Ontology Information
| HPRD ID | 7944 |
|---|---|
| Molecular Class | Intracellular ligand gated channel |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.