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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CNDP2 55748 CNDP dipeptidase 2 (metallopeptidase M20 family)  18FLJ10830, CN2, HsT2298, CPGL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24885395   2014Cell line : FHC, DLD 1, LS174T, LoVo, RKO HCT116, HT29, SW480

Source : ATCC,Tissue from First affiliated hospital of Sun Yat-Sen University.

Sample Type : CRC tumor and normal tissue

No. of Sample : 150 CRC and 33 colon polyp

Stage : TNM Stage I-IV

Immunohistochemistry,Western blotting,Flow cytometry,Cell growth assayUp-regulation-Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo.


Gene Details



NC_000018.9 (72163500..72190689)

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Gene Type protein coding
Gene Family -
Description CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]  
Chromosome 18
Location 18q22.3
Start 72163500  
End 72190689  
Strand +  
Gene Sequence

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Length 27190  
OMIM ID 169800   
HGNC ID HGNC:24437   
Unigene ID Hs.149185   
Ensembl ID ENSG00000133313   
PharmGKB ID PA134975242   

mRNA Information


mRNA ID ?NM_001168499.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12006.1



Protein Information


      
Protein IDNP_001161971.1
Protein NameCNDP dipeptidase 2 (metallopeptidase M20 family)
Molecular Wt. (Da)0
Protein Sequence

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Length 475  
Uniprot IDQ9H5V8
Ensembl Protein ID ENSP00000296129  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation9
SPhosphorylation299
SPhosphorylation313
SPhosphorylation315
SPhosphorylation324

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                        
Pathway Name Pathway ID
Arginine and proline metabolism hsa00330
beta-Alanine metabolism hsa00410
Histidine metabolism hsa00340
Metabolic pathways hsa01100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd056767-473  M20_dipept_like_CNDP
cl148767-473  Zinc_peptidase_like superfamily
cd0389319-469  M20_Dipept_like
cd0568022-470  M20_dipept_like_3
cd0567719-467  M20_dipept_like_DUG2_type
cd0568118-467  M20_dipept_like_4
PRK0790711-451  PRK07907
cd0567819-467  M20_dipept_like_1
cd0567917-269  M20_dipept_like_2
cd0865922-467  M20_ArgE_DapE_like
cd0568219-470  M20_dipept_like_5
cd038889-174  M20_PepV
cd0801142-412  M20_ArgE_DapE_like6
cd0387328-215  Zinc_peptidase_like
cd0567581-195  M20_yscS_like
cd0389522-172  M20_ArgE_DapE_like2
cd0565016-187  M20_ArgE_DapE_like1
PRK085964-304  PRK08596
cd0389181-167  M20_DapE_proteobac
cd0389422-177  M20_ArgE
cd0388518-177  M20_CPDG2
cd0565188-177  M20_ArgE_DapE_like5
cd0564919-151  M20_ArgE_DapE_like4
cd0567486-146  M20_yscS
cd0801379-180  M20_ArgE_DapE_like3
cd0564653-134  M20_AcylaseI_like
cd0801291-138  M20_ArgE-related
cd0389682-221  M20_PAAh_like
cd0565382-229  M20_ArgE_LysK
pfam07687293-367  M20_dimer
cd0269746-171  M20_like
cd0565299-172  M20_ArgE_DapE_like_fungal
cd0564784-182  M20_DapE_actinobac
PRK0820110-473  PRK08201
PRK091041-450  PRK09104
COG06247-469  ArgE
PRK0644616-473  PRK06446
pfam0154695-469  Peptidase_M20
PRK0707922-269  PRK07079
TIGR0191019-461  DapE-ArgE
PRK0865122-416  PRK08651
PRK0691510-172  PRK06915
TIGR0188791-174  dipeptidaselike
PRK0731890-174  PRK07318
PRK0913312-191  PRK09133
PRK072059-168  PRK07205
PRK1398312-187  PRK13983
TIGR0188683-174  dipeptidase
TIGR0189222-353  AcOrn-deacetyl
PRK0752298-156  PRK07522
TIGR0124619-193  dapE_proteo
PRK1300992-167  PRK13009
PRK0858891-172  PRK08588
PRK1301381-219  PRK13013
PRK0826286-172  PRK08262
PRK0855479-171  PRK08554
PRK0615690-173  PRK06156
PRK0790681-184  PRK07906
PRK0683779-151  PRK06837
PRK130047-143  PRK13004
PRK0613315-231  PRK06133
TIGR0352635-145  selenium_YgeY
PRK0511181-135  PRK05111
PRK0747341-179  PRK07473
PRK073386-170  PRK07338
TIGR0188060-184  Ac-peptdase-euk
PRK0873799-146  PRK08737
PRK0865261-172  PRK08652
PRK0444383-172  PRK04443
PRK0046698-229  PRK00466


Ontology Information


   
HPRD ID14817
Molecular ClassMetallo protease
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessCell differentiation (GO:0030154)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO