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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24934327 | 2015 | Cell line : SW480, SW620 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 27 tissue specimens (14 CRC and 13 normal tissue) and 125 LNs were dissected from 14 patients with CRC. Stage : Dukes' stage A, B, and C groups | Human Whole Genome Bioarray | Up-regulation | - | AKR1C3 and CNN3 expressions are accurate and suitable markers for the diagnosis of LN metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p22-p21 |
| Start | 95362507 |
| End | 95392735 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 30229 |
| OMIM ID | 602374 |
| HGNC ID | HGNC:2157 |
| Unigene ID | Hs.483454 |
| Ensembl ID | ENSG00000117519 |
| PharmGKB ID | PA26667 |
mRNA Information
| mRNA ID | NM_001286055.1 |
|---|---|
| Exon | join(1..386,23700..23821,24036..24102,25439..25555, 27707..27853,29141..30275) | mRNA Sequence | Download Select all |
| Length | 1974 |
Protein Information
| Protein ID | NP_001272984.1 |
|---|---|
| Protein Name | calponin 3, acidic |
| Molecular Wt. (Da) | 31249 |
| Protein Sequence | Download Select all |
| Length | 283 |
| Uniprot ID | P19652 |
| Ensembl Protein ID | ENSP00000394936 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 261 |
| S | Phosphorylation | 323;- |
| S | Phosphorylation | 296;- |
| T | Phosphorylation | 290;- |
| S | Phosphorylation | 244 |
| S | Phosphorylation | 162 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3936 | LCP1 | 1082 | NP_002289.2 | in vivo | 11591653 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 28-125 | CH |
| cl00030 | 28-125 | CH superfamily |
| smart00033 | 30-125 | CH |
| pfam00307 | 29-125 | CH |
| pfam00402 | 164-189 | Calponin |
| cl02859 | 164-189 | Calponin superfamily |
| pfam00402 | 243-268 | Calponin |
| cl02859 | 243-268 | Calponin superfamily |
| pfam00402 | 204-229 | Calponin |
| cl02859 | 204-229 | Calponin superfamily |
| COG5199 | 16-188 | SCP1 |
| COG5261 | 30-133 | IQG1 |
Ontology Information
| HPRD ID | 6850 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.