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General Information
- Evidence
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- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16507901 | 2006 | Cell line : - Source : Kumamoto University School of Medicine. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 14 Stage : Duke Stage A,B,C. | Immunohistochemistry,In Situ Hybridization,RT-PCR,Bisulfite Sequencing,Luciferase Assays. | Hypermethylation | - | The hypermethylation of the bidirectional promoter region of COL4A5/COL4A6 is one of the events that is responsible for the loss of expression of the alpha5(IV)/alpha6(IV) chains and the remodeling of the epithelial BM during cancer cell invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Collagens |
| Description | This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] | Chromosome | X |
| Location | Xq22 |
| Start | 107683019 |
| End | 107940775 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 257757 |
| OMIM ID | 303630 |
| HGNC ID | HGNC:2207 |
| Unigene ID | Hs.369089 |
| Ensembl ID | ENSG00000188153 |
| PharmGKB ID | PA26722 |
mRNA Information
| mRNA ID | XM_006724616.2 |
|---|---|
| Exon | join(1..60,271..471,100011..100070,119329..119418, 124147..124191,128894..128938,129024..129086, 131678..131731,132076..132102,133839..133919, 136175..136237,138217..138252,138343..138384, 138556..138648,140798..140851,140947..141003, 141248..141292,143149..143202,144749..144790, 146880..147012,151323..151496,151826..151909, 155774..155866,157263..157333,157642..157833, 158967..159135,161658..161750,162150..162254, 163229..163326,167007..167157,175176..175289, 180524..180691,182068..182157,182941..183090, 184501..184599,185970..186059,186475..186614, 215596..215722,225772..225852,226761..226859, 227398..227448,228584..228769,230493..230501, 235010..235018,237765..237898,240944..241016, | mRNA Sequence | Download Select all |
| Length | 6423 |
Protein Information
| Protein ID | XP_006724679.1 |
|---|---|
| Protein Name | collagen, type IV, alpha 5 |
| Molecular Wt. (Da) | 161501 |
| Protein Sequence | Download Select all |
| Length | 1691 |
| Uniprot ID | P05121 |
| Ensembl Protein ID | ENSP00000223095 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 543;- |
| S | Phosphorylation | 543;- |
| S | Phosphorylation | 543;- |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 | APP | 100 | NP_000475.1 | in vitro | 9136074 |
| 1634 | DCN | 501 | NP_001911.1 | in vivo | 10382266 |
| 2199 | FBLN2 | 630 | NP_001004019.1 | in vivo | 7500359 |
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 3997552 |
| 4318 | MMP9 | 387 | NP_004985.2 | in vivo | 9878537 |
| 5008 | OSM | 1300 | NP_065391.1 | in vitro | 11711546 |
| 5270 | SERPINE2 | 1510 | NP_001130002.1 | in vivo | 8006028 |
| 9921 | RNF10 | 11496 | NP_055683.3 | yeast 2-hybrid | 16169070 |
| 22918 | CD93 | 396 | NP_036204.2 | in vitro;in vivo | 1377218 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amoebiasis | hsa05146 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Protein digestion and absorption | hsa04974 |
| Small cell lung cancer | hsa05222 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01413 | 1461-1570 | C4 |
| cl02467 | 1461-1570 | C4 superfamily |
| smart00111 | 1571-1684 | C4 |
| cl02467 | 1571-1684 | C4 superfamily |
| pfam01413 | 1571-1684 | C4 |
| smart00111 | 1461-1570 | C4 |
| pfam01391 | 1285-1344 | Collagen |
| cl22949 | 1285-1344 | Collagen superfamily |
| pfam01391 | 1288-1346 | Collagen |
| pfam01391 | 515-587 | Collagen |
| cl22949 | 515-587 | Collagen superfamily |
| pfam01391 | 638-700 | Collagen |
| cl22949 | 638-700 | Collagen superfamily |
| pfam01391 | 1057-1116 | Collagen |
| cl22949 | 1057-1116 | Collagen superfamily |
Ontology Information
| HPRD ID | 3967 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.