Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| COPS2 | 9318 | COP9 signalosome subunit 2 | 15 | TRIP15, ALIEN, CSN2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26148070 | 2015 | Cell line : SW480 Source : VU University Medical Center in Amsterdam Sample Type : CRC tumor and normal tissue No. of Sample : 100 CRC (48 adenomas and 52 carcinomas) Stage : - | real time RT-PCR,Cell viability | Down-regulation | - | Sgnificant overexpression of miR-15a-3p due to gain of 13q is functionally relevant in CRC, with UCP2 and COPS2 as candidate target genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 15 |
| Location | 15q21.2 |
| Start | 49417471 |
| End | 49447854 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 30384 |
| OMIM ID | 604508 |
| HGNC ID | HGNC:30747 |
| Unigene ID | Hs.369614 |
| Ensembl ID | - |
| PharmGKB ID | PA134952445 |
Protein Information
| Protein ID | NP_001137359.1 |
|---|---|
| Protein Name | COP9 signalosome subunit 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 443 |
| Uniprot ID | Q8IWU6 |
| Ensembl Protein ID | ENSP00000260128 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 279 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2671 | GFER | 2954 | NP_005253.3 | in vivo | 15304329 |
| 3394 | IRF8 | 3336 | NP_002154.1 | in vitro;in vivo | 10991940 |
| 5914 | RARA | 6769 | NP_000955.1 | yeast 2-hybrid | 10207062 |
| 6256 | RXRA | 1577 | NP_002948.1 | in vitro;yeast 2-hybrid | 7776974 |
| 7025 | NR2F1 | 584 | NP_005645.1 | in vitro | 10207062 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro | 11285227 |
| 8065 | CUL5 | 3444 | NP_003469.2 | in vitro | 11337588 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01399 | 309-413 | PCI |
| cl02111 | 309-413 | PCI superfamily |
| smart00753 | 346-427 | PAM |
| smart00088 | 346-427 | PINT |
| pfam10075 | 272-415 | PCI_Csn8 |
| cl19397 | 272-415 | PCI_Csn8 superfamily |
| COG5159 | 40-434 | RPN6 |
| COG5187 | 315-426 | RPN7 |
Ontology Information
| HPRD ID | 15145 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.