CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
11911970	2002	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemical analysis, polymerase chain reaction-single strand conformation polymorphism.	Up-regulation	-	The elevated expression levels of c-Crk-II might be related to the development of human cancers.

Gene Details

NC_000017.10 (1324647..1359561, complement)
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Gene Type	protein coding
Gene Family	SH2 domain containing
Description	This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17p13
Start	1324647
End	1359561
Strand	-
Gene Sequence	Download Select all
Length	34915
OMIM ID	164762
HGNC ID	HGNC:2362
Unigene ID	Hs.461896
Ensembl ID	ENSG00000167193
PharmGKB ID	PA26880

mRNA Information

mRNA ID	NM_005206.4
Exon	join(1..391,19113..19478,32618..34915)
mRNA Sequence	Download Select all
Length	3055

CDS Information

Location	151..765
CDS Sequence	Download Select all
CCDS ID	CCDS11002.1

Protein Information

Protein ID	NP_005197.3
Protein Name	v-crk avian sarcoma virus CT10 oncogene homolog
Molecular Wt. (Da)	22774
Protein Sequence	Download Select all
Length	204
Uniprot ID	P09619
Ensembl Protein ID	ENSP00000261799

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	41
S	Phosphorylation	41
Y	Phosphorylation	221
Y	Phosphorylation	221
Y	Phosphorylation	221
Y	Phosphorylation	221
Y	Phosphorylation	239;-
S	Phosphorylation	74
S	Phosphorylation	83
S	Phosphorylation	74
S	Phosphorylation	83
S	Phosphorylation	40
S	Phosphorylation	40
T	Phosphorylation	42
T	Phosphorylation	42
S	Phosphorylation	304
S	Phosphorylation	194
S	Phosphorylation	85
S	Phosphorylation	85
S	Phosphorylation	125
S	Phosphorylation	125
S	Phosphorylation	196

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
613	BCR	1044	NP_004318.3	yeast 2-hybrid	8978305
699	BUB1	3907	NP_004327.1	yeast 2-hybrid	16189514
2321	FLT1	1297	NP_002010.2	in vitro	9722576
2885	GRB2	150	NP_002077.1	in vitro;in vivo	866 290 710 970 810
3643	INSR	975	NP_000199.2	yeast 2-hybrid	15522217
3791	KDR	1867	NP_002244.1	in vitro	15051508
3815	KIT	1287	NP_000213.1	in vitro;in vivo	909 257 412 878 163
4690	NCK1	2740	NP_006144.1	in vivo	9837978
4914	NTRK1	1869	NP_002520.2	in vitro;in vivo	75 094 497 657 647
5295	PIK3R1	1381	NP_852664.1	in vivo	12878163
5359	PLSCR1	8855	NP_066928.1	yeast 2-hybrid	16189514
5706	PSMC6	4086	NP_002797.3	yeast 2-hybrid	16189514
5747	PTK2	2859	NP_005598.3	in vitro;in vivo	113 140 307 509 446 000 000 000 000 000
6310	ATXN1	3333	NP_000323.2	yeast 2-hybrid	16713569
6464	SHC1	2780	NP_001123512.1	in vitro;in vivo	803 582 594 615 879 000 000
6776	STAT5A	3301	NP_003143.2	in vitro;in vivo	11097834
6777	STAT5B	5037	NP_036580.2	in vitro;in vivo	11 097 834 107 206 900 000 000
8660	IRS2	2878	NP_003740.2	in vitro	8621590
9564	BCAR1	4248	NP_055382.2	in vivo	102 084 191 075 382 000 000 000
10818	FRS2	6372	NP_006645.3	in vitro	1 009 267 812 154 000
55211	DPPA4	16836	NP_060659.3	yeast 2-hybrid	16189514

Pathway Information

Pathway Name	Pathway ID
Bacterial invasion of epithelial cells	hsa05100
Chemokine signaling pathway	hsa04062
Chronic myeloid leukemia	hsa05220
ErbB signaling pathway	hsa04012
Fc gamma R-mediated phagocytosis	hsa04666
Focal adhesion	hsa04510
Insulin signaling pathway	hsa04910
MAPK signaling pathway	hsa04010
MicroRNAs in cancer	hsa05206
Neurotrophin signaling pathway	hsa04722
Pathways in cancer	hsa05200
Rap1 signaling pathway	hsa04015
Regulation of actin cytoskeleton	hsa04810
Renal cell carcinoma	hsa05211
Shigellosis	hsa05131

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd09926	5-122	SH2_CRK_like
cl15255	5-122	SH2 superfamily
cd11758	135-189	SH3_CRK_N
cl17036	135-189	SH3 superfamily
cd11759	237-293	SH3_CRK_C
cl17036	237-293	SH3 superfamily
smart00252	13-109	SH2
cd00173	12-104	SH2
pfam00017	13-104	SH2
smart00326	133-188	SH3
cd11770	136-189	SH3_Nephrocystin
cd11769	139-189	SH3_CSK
cd10337	13-104	SH2_BCAR3
cd10347	Dec-63	SH2_Nterm_shark_like
cd00174	136-186	SH3
cd09931	13-105	SH2_C-SH2_SHP_like
cd09937	13-105	SH2_csk_like
pfam07653	239-292	SH3_2
pfam00018	138-184	SH3_1
cd11805	136-189	SH3_GRB2_like_C
cd11845	137-186	SH3_Src_like
cd11767	137-188	SH3_Nck_3
cd09941	12-123	SH2_Grb2_like
cd09943	11-105	SH2_Nck_family
cd09933	Jun-62	SH2_Src_family
cd09935	Sep-63	SH2_ABL
cd09923	Dec-52	SH2_SOCS_family
cd09925	10-103	SH2_SHC
cd09942	13-51	SH2_nSH2_p85_like
cd09944	13-62	SH2_Grb7_family
cd11768	137-189	SH3_Tec_like
cd11772	137-188	SH3_OSTF1
cd11862	136-183	SH3_MPP
cd10341	13-113	SH2_N-SH2_PLC_gamma_like
cd09932	9-109	SH2_C-SH2_PLC_gamma_like
cd11904	137-187	SH3_Nck1_3
cd11786	136-188	SH3_SH3RF_1
cd09930	Jul-63	SH2_cSH2_p85_like
pfam07653	136-189	SH3_2
cd11855	137-188	SH3_Sho1p
cd10370	Sep-62	SH2_Src_Src42
cd11804	138-187	SH3_GRB2_like_N
cd12033	136-183	SH3_MPP7
cd10354	13-62	SH2_Cterm_RasGAP
cd10360	13-62	SH2_Srm
cd10413	13-62	SH2_Grb7
cd12046	136-188	SH3_p67phox_C
cd11956	139-187	SH3_srGAP4
cd10414	Dec-62	SH2_Grb14
cd11903	137-187	SH3_Nck2_3
cd11951	136-187	SH3_GRAP_C
cd09934	Sep-62	SH2_Tec_family
cd10408	13-129	SH2_Nck1
cd11840	137-188	SH3_Intersectin_5
cd11842	136-188	SH3_Ysc84p_like
cd11964	137-187	SH3_STAM1
cd11905	135-187	SH3_Tec
cd11861	136-183	SH3_DLG-like
cd11823	138-188	SH3_Nostrin
cd10348	13-62	SH2_Cterm_shark_like
cd09945	13-118	SH2_SHB_SHD_SHE_SHF_like
cd11949	136-188	SH3_GRB2_C
cd09938	13-62	SH2_N-SH2_Zap70_Syk_like
pfam14604	139-188	SH3_9
cd09940	13-109	SH2_Vav_family
cd11948	139-188	SH3_GRAP_N
cd11928	136-188	SH3_SH3RF3_1
cd11877	137-188	SH3_PIX
cd10361	13-105	SH2_Fps_family
cd11824	138-189	SH3_PSTPIP1
cd11803	138-188	SH3_Endophilin_A
cd11963	134-187	SH3_STAM2
cd11998	137-188	SH3_PACSIN1-2
cd11946	139-188	SH3_GRB2_N
cd12035	136-185	SH3_MPP1-like
cd10383	Oct-52	SH2_SOCS2
cd11883	136-183	SH3_Sdc25
cd09927	13-51	SH2_Tensin_like
cd10365	13-62	SH2_Src_Src
cd11806	135-187	SH3_PRMT2
cd11858	138-188	SH3_Myosin-I_fungi
cd10346	13-59	SH2_SH2B_family
cd10387	Oct-55	SH2_SOCS6
cd10412	Nov-59	SH2_SH2B3
cd11920	138-189	SH3_Sorbs2_1
cd10388	Nov-60	SH2_SOCS7
cd12009	136-187	SH3_Blk
cd10415	13-107	SH2_Grb10
cd11781	138-188	SH3_Sorbs_1
cd12007	139-187	SH3_Yes
cd11763	136-188	SH3_SNX9_like
cd11819	138-188	SH3_Cortactin_like
cd11782	138-188	SH3_Sorbs_2
cd11771	136-188	SH3_Pex13p_fungal
cd11875	136-188	SH3_CD2AP-like_3
cd11839	246-293	SH3_Intersectin_4
cd09929	Jun-57	SH2_BLNK_SLP-76
cd11860	136-187	SH3_DLG5
cd10352	14-60	SH2_a2chimerin_b2chimerin
cd12142	239-287	SH3_D21-like
cd11837	137-187	SH3_Intersectin_2
cd10409	11-105	SH2_Nck2
cd11996	137-188	SH3_Intersectin2_5
cd11820	137-189	SH3_STAM
cd12036	136-183	SH3_MPP5
cd11817	136-186	SH3_Eve1_4
cd10718	Sep-52	SH2_CIS
cd12006	139-187	SH3_Fyn_Yrk
cd11908	137-189	SH3_ITK
cd11843	137-188	SH3_PACSIN
cd10384	Sep-55	SH2_SOCS3
cd12081	136-185	SH3_CASK
cd12008	139-187	SH3_Src
cd11919	138-188	SH3_Sorbs1_1
cd11762	136-188	SH3_FCHSD_2
cd11997	137-188	SH3_PACSIN3
cd10340	13-104	SH2_N-SH2_SHP_like
cd11809	139-187	SH3_srGAP
cd11999	137-188	SH3_PACSIN_like
cd11818	138-186	SH3_Eve1_5
cd11906	137-187	SH3_BTK
cd12061	137-189	SH3_betaPIX
cd11773	137-186	SH3_Sla1p_1
cd11829	138-187	SH3_GAS7
cd12039	136-183	SH3_MPP3
cd11960	137-188	SH3_Abp1_eu
cd11851	137-189	SH3_RIM-BP
cd10356	Dec-59	SH2_ShkA_ShkC
cd11978	250-291	SH3_VAV3_2
cd12004	137-189	SH3_Lyn
cd11827	137-189	SH3_MyoIe_If_like
cd10344	13-62	SH2_SLAP
cd11790	137-189	SH3_Amphiphysin
cd10362	Sep-62	SH2_Src_Lck
cd11961	137-188	SH3_Abp1_fungi_C2
cd11828	136-187	SH3_ARHGEF9_like
cd12056	135-183	SH3_CD2AP_3
cd10411	13-59	SH2_SH2B2
cd10367	13-62	SH2_Src_Fgr
cd11812	137-187	SH3_AHI-1
cd11849	137-188	SH3_SPIN90
cd12030	134-183	SH3_DLG4
cd11823	248-291	SH3_Nostrin
cd11864	138-188	SH3_PEX13_eumet
cd11947	138-188	SH3_GRAP2_N
cd12080	136-185	SH3_MPP1
cd11907	137-187	SH3_TXK
cd11934	138-188	SH3_Lasp1_C
cd11813	138-188	SH3_SGSM3
cd10355	12-104	SH2_DAPP1_BAM32_like
cd10358	13-62	SH2_PTK6_Brk
cd11875	239-287	SH3_CD2AP-like_3
cd10418	13-62	SH2_Src_Fyn_isoform_a_like
cd11976	138-189	SH3_VAV1_2
cd11829	256-291	SH3_GAS7
cd11953	137-183	SH3_ASPP2
cd10402	Jul-63	SH2_C-SH2_Zap70
cd10349	13-63	SH2_SH2D2A_SH2D7
cd12005	137-189	SH3_Lck
cd10368	13-62	SH2_Src_Fyn
cd10396	9-105	SH2_Tec_Itk
cd10391	Dec-62	SH2_SHE
cd11970	137-189	SH3_PLCgamma1
cd12060	137-191	SH3_alphaPIX
cd12142	136-188	SH3_D21-like
cd11935	138-188	SH3_Nebulette_C
cd11873	137-189	SH3_CD2AP-like_1
cd10353	Nov-62	SH2_Nterm_RasGAP
cd12054	138-189	SH3_CD2AP_2
cd11764	136-183	SH3_Eps8
cd10343	12-105	SH2_SHIP
cd11927	138-188	SH3_SH3RF1_1
cd00174	239-290	SH3
cd11995	137-188	SH3_Intersectin1_5
cd11830	139-189	SH3_VAV_2
cd11825	137-189	SH3_PLCgamma
cd10366	13-62	SH2_Src_Yes
cd11950	137-188	SH3_GRAP2_C
cd12034	136-183	SH3_MPP4
cd11933	137-188	SH3_Nebulin_C
cd11821	137-186	SH3_ASAP
cd11808	136-189	SH3_Alpha_Spectrin
cd11968	240-293	SH3_SASH3
cd12032	131-183	SH3_DLG2
smart00326	249-292	SH3
cd10369	Sep-62	SH2_Src_Frk
cd11830	250-291	SH3_VAV_2
cd11882	137-188	SH3_GRAF-like
cd10392	13-59	SH2_SHF
cd12031	136-172	SH3_DLG1
cd11775	135-188	SH3_Sla1p_3
cd12021	138-188	SH3_p47phox_1
cd10386	14-52	SH2_SOCS5
cd10406	13-112	SH2_Vav2
cd11841	137-187	SH3_SH3YL1_like
cd10382	Sep-51	SH2_SOCS1
cd11955	139-187	SH3_srGAP1-3
cd11974	136-187	SH3_ASEF2
cd10405	13-112	SH2_Vav1
cd11850	139-187	SH3_Abl
cd11962	140-188	SH3_Abp1_fungi_C1
cd11866	136-187	SH3_SKAP1-like
cd12072	136-188	SH3_FNBP1L
cd11897	138-188	SH3_SNX18
cd10399	Dec-60	SH2_Tec_Bmx
cd10417	13-63	SH2_SH2D7
cd10397	Jun-62	SH2_Tec_Btk
cd11865	139-188	SH3_Nbp2-like
cd11894	136-188	SH3_FCHSD2_2
cd10410	13-59	SH2_SH2B1
cd10363	Sep-62	SH2_Src_HCK
cd12073	139-188	SH3_HS1
cd11958	137-186	SH3_RUSC1
cd09946	13-63	SH2_HSH2_like
cd11847	139-187	SH3_Brk
cd11800	136-189	SH3_DNMBP_C2_like
cd11978	139-189	SH3_VAV3_2
cd10385	14-52	SH2_SOCS4
cd11787	138-180	SH3_SH3RF_2
cd10419	13-62	SH2_Src_Fyn_isoform_b_like
cd11870	137-188	SH3_p67phox-like_C
cd11822	240-290	SH3_SASH_like
cd11816	138-187	SH3_Eve1_3
cd10351	Jun-63	SH2_SH2D4B
cd10350	13-63	SH2_SH2D4A
cd11954	137-183	SH3_ASPP1
cd11922	139-188	SH3_Sorbs1_2
cd11833	136-189	SH3_Stac_1
cd11929	138-188	SH3_SH3RF2_1
cd12014	144-189	SH3_RIM-BP_1
cd12061	256-292	SH3_betaPIX
cd10364	Sep-62	SH2_Src_Lyn
cd10390	13-59	SH2_SHD
cd11994	256-294	SH3_Intersectin2_4
cd11789	137-189	SH3_Nebulin_family_C
cd11896	138-188	SH3_SNX33
cd11807	137-183	SH3_ASPP
cd11986	136-187	SH3_Stac3_1
cd12057	136-188	SH3_CIN85_3
cd11959	139-188	SH3_Cortactin
cd10389	13-59	SH2_SHB
cd11873	256-292	SH3_CD2AP-like_1
cd12053	141-191	SH3_CD2AP_1
cd12060	249-292	SH3_alphaPIX
cd11967	240-294	SH3_SASH1
cd12029	136-172	SH3_DLG3
cd12012	139-188	SH3_RIM-BP_2
cd11966	137-187	SH3_ASAP2
cd10357	Oct-59	SH2_ShkD_ShkE
cd11895	137-189	SH3_FCHSD1_2
cd12052	256-292	SH3_CIN85_1
cd11878	137-186	SH3_Bem1p_1
cd11898	138-188	SH3_SNX9
cd11856	138-189	SH3_p47phox_like
cd11900	133-189	SH3_Nck1_1
cd11836	136-189	SH3_Intersectin_1
cd11991	135-187	SH3_Intersectin1_3
cd12054	241-294	SH3_CD2AP_2
cd11810	137-186	SH3_RUSC1_like
cd12045	136-187	SH3_SKAP2
cd11826	136-188	SH3_Abi
cd12057	250-294	SH3_CIN85_3
cd11828	249-293	SH3_ARHGEF9_like
cd11985	136-189	SH3_Stac2_C
cd11887	137-189	SH3_Bbc1
cd10407	13-62	SH2_Vav3
cd11973	136-177	SH3_ASEF
cd12053	249-292	SH3_CD2AP_1
cd11796	256-287	SH3_DNMBP_N3
cd11965	137-187	SH3_ASAP1
cd12055	247-292	SH3_CIN85_2
cd11921	138-188	SH3_Vinexin_1
cd12055	138-189	SH3_CIN85_2
cd10401	9-104	SH2_C-SH2_Syk_like
cd11877	256-293	SH3_PIX
cd11844	136-183	SH3_CAS
cd11976	250-291	SH3_VAV1_2
cd11796	138-187	SH3_DNMBP_N3
cd11765	136-187	SH3_Nck_1
cd11930	138-187	SH3_SH3RF1_2
cd12003	138-183	SH3_EFS
cd11774	137-187	SH3_Sla1p_2
cd10371	Sep-62	SH2_Src_Blk
cd11779	137-189	SH3_Irsp53_BAIAP2L
cd10400	Sep-60	SH2_SAP1a
cd11910	138-188	SH3_PI3K_p85alpha
cd10398	Sep-59	SH2_Tec_Txk
cd11987	136-189	SH3_Intersectin1_1
cd11879	136-188	SH3_Bem1p_2
cd11832	256-287	SH3_Shank
cd11977	139-189	SH3_VAV2_2
cd11874	256-287	SH3_CD2AP-like_2
cd11859	136-163	SH3_ZO
cd10342	13-62	SH2_SAP1
cd12037	136-183	SH3_MPP2
cd12059	139-187	SH3_MLK1-3
cd12038	136-187	SH3_MPP6
cd12000	138-183	SH3_CASS4
cd11952	137-186	SH3_iASPP
cd11888	136-186	SH3_ARHGAP9_like
cd11805	256-291	SH3_GRB2_like_C
cd11826	251-291	SH3_Abi
cd11972	135-188	SH3_Abi2

Ontology Information

HPRD ID	3956
Molecular Class	Adapter molecule
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report