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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24817059 | 2014 | Cell line : - Source : - Sample Type : Serum sample No. of Sample : 144 Stage : TNM Stage IV | - | Up-regulation | - | A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer |
| 23985781 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 288 CRC and 576 controls. Stage : TNM Stage I- IV | - | Up-regulation | - | Circulating CRP level is positively associated with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. | Chromosome | 1 |
| Location | 1q23.2 |
| Start | 159712289 |
| End | 159714609 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2321 |
| OMIM ID | 123260 |
| HGNC ID | HGNC:2367 |
| Unigene ID | Hs.76452 |
| Ensembl ID | ENSG00000132693 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011509207.1 |
|---|---|
| Exon | join(1..185,472..1107,1816..2321) | mRNA Sequence | Download Select all |
| Length | 1327 |
CDS Information
| Location | join(125..185,472..1085) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS30911.1 |
Protein Information
| Protein ID | NP_000558.2 |
|---|---|
| Protein Name | C-reactive protein, pentraxin-related |
| Molecular Wt. (Da) | 23047 |
| Protein Sequence | Download Select all |
| Length | 224 |
| Uniprot ID | P49841 |
| Ensembl Protein ID | ENSP00000264235 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 54;115 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 325 | APCS | 101 | NP_001630.1 | in vitro | 81 445 691 477 104 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1B09 |
|---|---|
| Resolution | 2.5 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | PROTEIN (C-REACTIVE PROTEIN) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00152 | 19-219 | PTX |
| cl22861 | 19-219 | LamG superfamily |
| smart00159 | 19-224 | PTX |
| pfam00354 | 26-220 | Pentaxin |
| pfam13385 | 25-189 | Laminin_G_3 |
Ontology Information
| HPRD ID | 7290 |
|---|---|
| Molecular Class | Complement protein |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02741 | DB05278 | inhaled insulin | SmallMoleculeDrug |