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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18360708 | 2008 | Cell line : HCT 116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray,Plasmids, transient transfections and luciferase assay,RT-PCR and real-time PCR | Up-regulation | - | CSTA, DAP13, TAF12, RIS1, CDKN3 and MAGOH were up-regulated, and KLHL11 and NCOA2 were down-regulated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q21 |
| Start | 122044011 |
| End | 122060816 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16806 |
| OMIM ID | 184600 |
| HGNC ID | HGNC:2481 |
| Unigene ID | Hs.518198 |
| Ensembl ID | ENSG00000121552 |
| PharmGKB ID | PA26983 |
mRNA Information
| mRNA ID | NM_005213.3 |
|---|---|
| Exon | join(1..195,12384..12485,16276..16806) | mRNA Sequence | Download Select all |
| Length | 838 |
Protein Information
| Protein ID | NP_005204.1 |
|---|---|
| Protein Name | cystatin A (stefin A) |
| Molecular Wt. (Da) | 10875 |
| Protein Sequence | Download Select all |
| Length | 98 |
| Uniprot ID | P18669 |
| Ensembl Protein ID | ENSP00000359991 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1508 | CTSB | 287 | NP_680090.1 | in vitro;in vivo | 10 353 845 145 038 800 000 000 |
| 1512 | CTSH | 288 | NP_004381.2 | in vitro | 12581647 |
| 1514 | CTSL1 | 293 | NP_001903.1 | in vitro | 129 217 799 585 570 |
| 5764 | PTN | 1199 | NP_002816.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00042 | Apr-61 | CY |
| cl09238 | Apr-61 | CY superfamily |
| pfam00031 | Apr-92 | Cystatin |
| smart00043 | Jan-61 | CY |
| PRK00137 | Feb-91 | rplI |
Ontology Information
| HPRD ID | 3076 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.