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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CTBP1 1487 C-terminal binding protein 1  4BARS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16508011   2006Cell line : HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Yeast two-hybrid screen,Cell culture and transfections,Western blotting,GST pulldown assays,CoimmunoprecipitationsUp-regulation-CtBP proteins represent putative targets for p53-independent tumor suppression by ARF.

25483087   2014Cell line : HCT 116, HT 29, WiDR, LS174T, Colo 320

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

MTT assay,colonosphere formation,western blotting, immunoprecipitations, PCR, flow cytometry,dual Luciferase AssayUp-regulation-Overexpression of C-terminal binding protein (CtBP), an NADH dependent transcriptional regulator, is often observed in colon cancer.


Gene Details



NC_000004.11 (1205228..1242908, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]  
Chromosome 4
Location 4p16
Start 1205228  
End 1242908  
Strand -  
Gene Sequence

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Length 37681  
OMIM ID 602618   
HGNC ID HGNC:2494   
Unigene ID Hs.208597   
Ensembl ID ENSG00000159692   
PharmGKB ID PA26995   

mRNA Information


mRNA ID NM_001328.2
Exon join(1129..1333,11912..12066,21906..22050,24683..24889, 34044..34258,35776..35906,36644..36771,37219..37336, 37826..38809)  
mRNA Sequence

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Length 2288  



CDS Information


   
Location 166..1488
CDS Sequence

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CCDS ID CCDS3348.1



Protein Information


      
Protein IDNP_001319.1
Protein NameC-terminal binding protein 1
Molecular Wt. (Da)47404
Protein Sequence

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Length 440  
Uniprot IDP52209
Ensembl Protein ID ENSP00000270776  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation428
KSumoylation417
SPhosphorylation300;-
SPhosphorylation289;-
YPhosphorylation381
YPhosphorylation370
SPhosphorylation422
SPhosphorylation411

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
659BMPR22880NP_001195.2in vitro15188402   
672BRCA1218NP_009231.2in vitro;in vivo10196224   
1936EEF1D560NP_115754.2in vitro;yeast 2-hybrid10567582   
2004ELK32593NP_005221.2in vitro;in vivo;yeast 2-hybrid10369679   
2033EP3004078NP_001420.2in vitro;in vivo15834423   
2122MECOM1310NP_001098547.3in vitro;in vivo1   131   327   611   328   810   
3064HTT883NP_002102.4in vivo11739372   
3065HDAC13143NP_004955.2in vitro;in vivo9650586   
4842NOS11226NP_000611.1in vitro;in vivo11590170   
5925RB11574NP_000312.2in vivo11583618   
6935ZEB11798NP_110378.3in vivo10359772   
8204NRIP13927NP_003480.2in vitro;in vivo;yeast 2-hybrid1   150   966   115   060   170   
8850KAT2B6780NP_003875.3in vitro15834423   


Pathway Information


                        
Pathway Name Pathway ID
Chronic myeloid leukemia hsa05220
Notch signaling pathway hsa04330
Pathways in cancer hsa05200
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0529928-346  CtBP_dh
cl2145428-346  NADB_Rossmann superfamily
cd0519830-337  formate_dh_like
cd1217258-338  PGDH_like_2
cd1217382-342  PGDH_4
pfam0038932-352  2-Hacid_dh
cd1217882-352  2-Hacid_dh_13
cd1217578-344  2-Hacid_dh_11
cd1216892-341  Mand_dh_like
cd1216281-329  2-Hacid_dh_4
cd0530142-341  GDH
cd0161930-342  LDH_like
pfam02826133-317  2-Hacid_dh_C
cd0530380-315  PGDH_2
cd1217731-349  2-Hacid_dh_12
cd1217483-352  PGDH_like_3
cd1217161-337  2-Hacid_dh_10
cd1218658-341  LDH
cd1218781-342  LDH_like_1
PRK1324360-349  PRK13243
cd1216173-332  GDH_like_1
cd1216943-341  PGDH_like_1
cd1218380-323  LDH_like_2
PRK0648755-342  PRK06487
cd1218551-336  HGDH_LDH_like
cd0530276-315  FDH
cd1216780-360  2-Hacid_dh_8
PRK0693281-335  PRK06932
cd1217680-337  PGDH_3
cd1215758-341  PTDH
cd1215669-329  HPPR
cd1217983-321  2-Hacid_dh_14
cd1218480-329  HGDH_like
cd1216564-345  2-Hacid_dh_6
PRK1540959-352  PRK15409
cd1215880-320  ErythrP_dh
cd0530083-355  2-Hacid_dh_1
cd1215585-322  PGDH_1
cd12180170-342  2-Hacid_dh_15
PLN0292881-348  PLN02928
PLN02306101-341  PLN02306
PLN0313976-315  PLN03139
PRK1248086-323  PRK12480
cd1216484-339  GDH_like_2
cd1216682-347  2-Hacid_dh_7
cd12159114-317  2-Hacid_dh_2
cd12160129-342  2-Hacid_dh_3
cd12163135-321  2-Hacid_dh_5
cd1217057-337  2-Hacid_dh_9
PRK0643690-354  PRK06436
cd1215485-310  FDH_GDH_like
PRK1546990-340  ghrA
COG011155-354  SerA
COG105281-353  LdhA
PRK1358180-352  PRK13581
TIGR0132780-352  PGDH
PRK0841030-341  PRK08410
PRK0757481-335  PRK07574
PRK1179081-315  PRK11790
PRK0860592-323  PRK08605
PRK0025773-340  PRK00257
PRK1543873-320  PRK15438


Ontology Information


   
HPRD ID2412
Molecular ClassTranscription regulatory protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO