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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20666480 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 84 CRC and healthy individuals Stage : - | 372-dots tissue array, Methylation isotope labeling assistant gel-enhanced liquid chromatography-mass spectrometry (GeLC-MS) | Down-regulation | - | Combined CTSD and A1AT should be strongly considered for clinical use in early diagnosis of early stage CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cathepsins |
| Description | This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015] | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 1773982 |
| End | 1785222 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11241 |
| OMIM ID | 116840 |
| HGNC ID | HGNC:2529 |
| Unigene ID | Hs.654447 |
| Ensembl ID | ENSG00000117984 |
| PharmGKB ID | PA27029 |
mRNA Information
| mRNA ID | NM_001909.4 |
|---|---|
| Exon | join(1..201,2525..2684,4354..4477,4906..5024,6437..6669, 8965..9087,9855..9999,10092..10190,10323..11241) | mRNA Sequence | Download Select all |
| Length | 2141 |
Protein Information
| Protein ID | NP_001900.1 |
|---|---|
| Protein Name | cathepsin D |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 412 |
| Uniprot ID | P08183 |
| Ensembl Protein ID | ENSP00000265724 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 134 |
| N | Glycosylation | 263 |
| E | Proteolytic Cleavage | 64 |
| S | Phosphorylation | 252 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 | APP | 100 | NP_000475.1 | in vitro;in vivo | 1 060 582 589 432 320 000 000 000 000 000 000 000 |
| 632 | BGLAP | 205 | NP_954642.1 | in vivo | 9076588 |
| 1471 | CST3 | 5056 | NP_000090.1 | in vitro | 2013314 |
| 1508 | CTSB | 287 | NP_680090.1 | in vitro | 10876156 |
| 3482 | IGF2R | 928 | NP_000867.2 | in vivo | 15258139 |
| 3486 | IGFBP3 | 899 | NP_001013416.1 | in vitro | 9275067 |
| 3487 | IGFBP4 | 900 | NP_001543.2 | in vitro | 9275067 |
| 3630 | INS | 1455 | NP_000198.1 | in vitro;in vivo | 11779865 |
| 5267 | SERPINA4 | 1004 | NP_006206.2 | in vitro | 1 134 192 111 258 660 |
| 6366 | CCL21 | 4113 | NP_002980.1 | in vitro | 12651610 |
| 6462 | SHBG | 1646 | NP_001031.2 | yeast 2-hybrid | 15862967 |
| 7038 | TG | 1782 | NP_003226.4 | in vitro | 1939080 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Lysosome | hsa04142 |
| Sphingolipid signaling pathway | hsa04071 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05490 | 73-408 | Cathepsin_D2 |
| cl11403 | 73-408 | pepsin_retropepsin_like superfamily |
| cd05485 | 68-408 | Cathepsin_D_like |
| cd06098 | 71-408 | phytepsin |
| cd05487 | 71-409 | renin_like |
| cd05478 | 69-407 | pepsin_A |
| cd05486 | 79-407 | Cathespin_E |
| cd05488 | 71-408 | Proteinase_A_fungi |
| cd05471 | 79-407 | pepsin_like |
| cd05477 | 76-409 | gastricsin |
| cd06097 | 79-407 | Aspergillopepsin_like |
| cd05473 | 79-407 | beta_secretase_like |
| cd05474 | 79-409 | SAP_like |
| cd05470 | 81-201 | pepsin_retropepsin_like |
| cd06096 | 77-409 | Plasmepsin_5 |
| cd05476 | 78-409 | pepsin_A_like_plant |
| pfam14543 | 79-207 | TAXi_N |
| cd05472 | 78-410 | cnd41_like |
| pfam07966 | 22-49 | A1_Propeptide |
| cl06833 | 22-49 | A1_Propeptide superfamily |
| pfam14541 | 334-407 | TAXi_C |
| cl19162 | 334-407 | TAXi_C superfamily |
| cd05475 | 78-405 | nucellin_like |
| pfam00026 | 78-409 | Asp |
| PTZ00165 | 24-410 | PTZ00165 |
| PTZ00147 | 71-411 | PTZ00147 |
| PTZ00013 | 71-409 | PTZ00013 |
| PLN03146 | 78-172 | PLN03146 |
Ontology Information
| HPRD ID | 2463 |
|---|---|
| Molecular Class | Aspartic protease |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07339 | DB00030 | Insulin Regular | BiotechDrug |
| P07339 | DB00071 | Insulin, porcine | BiotechDrug |