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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25652886 | 2015 | Cell line : HCT116, SW480 Source : Yixing People's Hospital, Yixing City in the south of Xiangsu Provinsce. Sample Type : CRC Tumor and normal tissue No. of Sample : 7 Stage : - | Immunohistochemistry | Up-regulation | - | CUL1 may serve as promising prognostic markers in CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 7 |
| Location | 7q36.1 |
| Start | 148395631 |
| End | 148498202 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 102572 |
| OMIM ID | 603134 |
| HGNC ID | HGNC:2551 |
| Unigene ID | Hs.146806 |
| Ensembl ID | ENSG00000055130 |
| PharmGKB ID | PA27047 |
mRNA Information
| mRNA ID | ?NM_003592.2 |
|---|---|
| Exon | join(1..82,31785..32085,55799..55973,58806..58973, 61127..61177,61371..61461,62156..62319,68384..68546, 69442..69572,85606..85713,85794..85900,88374..88422, 88812..88943,90380..90497,91573..91649,92133..92264, 94549..94641,99635..99682,99760..99842,100395..100500, 101098..101211,102325..102933) | mRNA Sequence | Download Select all |
| Length | 3102 |
Protein Information
| Protein ID | NP_003583.2 |
|---|---|
| Protein Name | cullin 1 |
| Molecular Wt. (Da) | 59263 |
| Protein Sequence | Download Select all |
| Length | 776 |
| Uniprot ID | Q9UGL1 |
| Ensembl Protein ID | ENSP00000356233 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Neddylation | 720 |
| S | Phosphorylation | 70 |
| T | Phosphorylation | 101 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1147 | CHUK | 2811 | NP_001269.3 | in vivo | 17914462 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 10559858 |
| 4793 | NFKBIB | 7260 | NP_002494.2 | in vitro | 14743216 |
| 4794 | NFKBIE | 5181 | NP_004547.2 | in vitro | 14743216 |
| 5880 | RAC2 | 3628 | NP_002863.1 | yeast 2-hybrid | 11445862 |
| 6500 | SKP1 | 3255 | NP_733779.1 | in vitro;in vivo | 982 754 217 290 223 |
| 6502 | SKP2 | 3256 | NP_005974.2 | in vitro;in vivo | 9430629 |
| 28996 | HIPK2 | 6039 | NP_073577.3 | in vivo | 18765672 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Circadian rhythm | hsa04710 |
| Herpes simplex infection | hsa05168 |
| Oocyte meiosis | hsa04114 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| TGF-beta signaling pathway | hsa04350 |
| Ubiquitin mediated proteolysis | hsa04120 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00182 | 455-590 | CULLIN |
| cl10551 | 455-590 | CULLIN superfamily |
| pfam10557 | 703-770 | Cullin_Nedd8 |
| cl11186 | 703-770 | Cullin_Nedd8 superfamily |
| smart00884 | 703-770 | Cullin_Nedd8 |
| pfam00888 | 21-671 | Cullin |
| COG5647 | 11-776 | COG5647 |
Ontology Information
| HPRD ID | 5107 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.