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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL1 | 2919 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 4 | SCYB1, GROa, MGSA-a, NAP-3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26104296 | 2015 | Cell line : Murine NIH3T3, SW48, SW620 Source : ATCC and Tissue sample from Memorial Sloan-Kettering Cancer Center. Sample Type : - No. of Sample : - Stage : TNM Stage I-IV | Soft agar growth assay,Murine xenograft tumor assay,Elisa,Immunofluorescence,Expression profile of human mucosal tissues | Up-regulation | - | CXCL1 inhibition suppressed tumorigenic growth of KRAS mutant CRC cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014] | Chromosome | 4 |
| Location | 4q13.3 |
| Start | 74735109 |
| End | 74737019 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1911 |
| OMIM ID | 155730 |
| HGNC ID | HGNC:4602 |
| Unigene ID | Hs.789 |
| Ensembl ID | - |
| PharmGKB ID | PA35050 |
mRNA Information
| mRNA ID | NM_001511.3 |
|---|---|
| Exon | join(1..179,278..401,515..598,1130..1911) | mRNA Sequence | Download Select all |
| Length | 1184 |
Protein Information
| Protein ID | NP_001502.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 107 |
| Uniprot ID | Q16799 |
| Ensembl Protein ID | ENSP00000267484 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| L | Proteolytic Cleavage | 41 |
| V | Proteolytic Cleavage | 62 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2532 | DARC | 192 | NP_001116423.1 | in vitro;in vivo | 7592830 |
| 3577 | CXCR1 | 908 | NP_000625.1 | in vivo | 13 795 938 702 798 |
| 3579 | CXCR2 | 907 | NP_001548.1 | in vivo | 8 550 564 894 012 180 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Legionellosis | hsa05134 |
| NOD-like receptor signaling pathway | hsa04621 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 40-102 | Chemokine_CXC |
| cl00134 | 40-102 | Chemokine superfamily |
| cd00169 | 44-101 | Chemokine |
| pfam00048 | 40-100 | IL8 |
| smart00199 | 40-100 | SCY |
| cd00272 | 45-100 | Chemokine_CC |
Ontology Information
| HPRD ID | 1577 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Ligand-dependent nuclear receptor activity (GO:0004879) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.