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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL11 | 6373 | chemokine (C-X-C motif) ligand 11 | 4 | H174, b-R1, I-TAC, IP-9 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24493023 | 2014 | Cell line : GFP-transfected CT26 Source : - Sample Type : - No. of Sample : Mouse model Stage : - | Intravital fluorescence microscopy and immunohistochemistry | Up-regulation and polymorphism | - | The results of the present study underline the interaction of CXCL12 and CXCL11 during tumor angiogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] | Chromosome | 4 |
| Location | 4q21 |
| Start | 76954835 |
| End | 76957350 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2516 |
| OMIM ID | 604852 |
| HGNC ID | HGNC:10638 |
| Unigene ID | Hs.632592 |
| Ensembl ID | ENSG00000169248 |
| PharmGKB ID | PA35569 |
mRNA Information
| mRNA ID | ?NM_001302123.1 |
|---|---|
| Exon | join(1..271,856..982,1079..1151,1386..2516) | mRNA Sequence | Download Select all |
| Length | 1603 |
Protein Information
| Protein ID | NP_001289052.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 11 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 94 |
| Uniprot ID | O43290 |
| Ensembl Protein ID | ENSP00000310448 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| P | Proteolytic Cleavage | 23 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1232 | CCR3 | 3167 | NP_001828.1 | in vitro | 11110785 |
| 2833 | CXCR3 | 2936 | AAP55851.1 | in vitro;in vivo | 152 733 039 625 760 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 28-90 | Chemokine_CXC |
| cl00134 | 28-90 | Chemokine superfamily |
| pfam00048 | 29-89 | IL8 |
| smart00199 | 29-88 | SCY |
Ontology Information
| HPRD ID | 6279 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.