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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | 10 | SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24482642 | 2013 | Cell line : - Source : Yongkang Veterans Hospital, Tainan Sample Type : Peripheral Blood No. of Sample : CRC patients 258 and healthy controls 300 Stage : - | Denaturing high performance liquid chromatography | Polymorhpism | - | CXCL12-G801A genotype may be associated with some clinical manifestations in CRC patients in Taiwan.The SNP distribution was higher in CRC patients with TNM stage II (117/258) than healthy controls (52/300). |
| 24493023 | 2014 | Cell line : CT26 Source : - Sample Type : - No. of Sample : - Stage : - | Cell migration assay, Flow cytomery, fluorescence microscopy, immunohistochemistry . | Up-regulation | - | Interaction of CXCL12 and CXCL11 during tumor angiogenesis ware obsereved. The combined blockade of both signaling pathways may provide an interesting anti-angiogenic approach for anti-tumor therapy. |
| 26078947 | 2015 | Cell line : LOVO, SW480, HTC116, SW620, HT29 Source : Shanghai Tongren Hospital Sample Type : CRC tumor and adjecent normal tissue No. of Sample : 35 Stage : - | real time RT- PCR and western blotting | Up-regulation | - | B7-H4 siRNA can effectively inhibit proliferation, invasion, and migration of LOVO cells by targeting CXCL12/CXCR4 and JAK2/STAT3 signaling, which can serve as a new target for colorectal carcinoma treatment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] | Chromosome | 10 |
| Location | 10q11.1 |
| Start | 44865601 |
| End | 44880545 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14945 |
| OMIM ID | 600835 |
| HGNC ID | HGNC:10672 |
| Unigene ID | Hs.522891 |
| Ensembl ID | ENSG00000107562 |
| PharmGKB ID | PA35602 |
mRNA Information
| mRNA ID | ?NM_000609.6 |
|---|---|
| Exon | join(1..153,4218..4265,12008..14945) | mRNA Sequence | Download Select all |
| Length | 3139 |
Protein Information
| Protein ID | NP_000600.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 12 |
| Molecular Wt. (Da) | 9207 |
| Protein Sequence | Download Select all |
| Length | 93 |
| Uniprot ID | P54578 |
| Ensembl Protein ID | ENSP00000261601 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| P | Proteolytic Cleavage | 23 |
| P | Proteolytic Cleavage | 23 |
| L | Proteolytic Cleavage | 26 |
| L | Proteolytic Cleavage | 26 |
| P | Proteolytic Cleavage | 23 |
| L | Proteolytic Cleavage | 26 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 920 | CD4 | 1740 | NP_000607.1 | in vitro | 10600606 |
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 11023498 |
| 4313 | MMP2 | 386 | NP_004521.1 | in vitro | 11571304 |
| 7852 | CXCR4 | 1217 | NP_001008540.1 | in vitro;in vivo | 102 338 518 752 281 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Intestinal immune network for IgA production | hsa04672 |
| Leukocyte transendothelial migration | hsa04670 |
| NF-kappa B signaling pathway | hsa04064 |
| Pathways in cancer | hsa05200 |
| Rheumatoid arthritis | hsa05323 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 27-88 | Chemokine_CXC |
| cl00134 | 27-88 | Chemokine superfamily |
| cd00169 | 31-87 | Chemokine |
| smart00199 | 27-85 | SCY |
| pfam00048 | 27-85 | IL8 |
Ontology Information
| HPRD ID | 4633 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P48061 | DB06822 | Tinzaparin | SmallMoleculeDrug |