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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL14 | 9547 | chemokine (C-X-C motif) ligand 14 | 5 | BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24938992 | 2014 | Cell line : HT29 Source : - Sample Type : CRC tumor and adjacent normal tissues No. of Sample : - Stage : - | RT-PCR, immunohistochemistry | Down-regulation | - | Downregulation of�CXCL14�expression in tumors was associated with lymph metastasis, tumor location, and clinicopathological stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014] | Chromosome | 5 |
| Location | 5q31 |
| Start | 134906369 |
| End | 134914969 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8601 |
| OMIM ID | 604186 |
| HGNC ID | HGNC:10640 |
| Unigene ID | Hs.483444 |
| Ensembl ID | ENSG00000145824 |
| PharmGKB ID | PA35571 |
Protein Information
| Protein ID | NP_004878.2 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 14 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 111 |
| Uniprot ID | Q9NTG7 |
| Ensembl Protein ID | ENSP00000372191 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00048 | 45-97 | IL8 |
| cl00134 | 45-97 | Chemokine superfamily |
| cd00273 | 36-97 | Chemokine_CXC |
Ontology Information
| HPRD ID | 9789 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.