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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17549409 | 2007 | Cell line : - Source : Sample Type : CRC tumor and Plasma No. of Sample : CRC 80 and paired normal mucosa, plasma 62 CRC and controls 71 Stage : - | ELISA,TaqMan system,Immunohistochemistry | Polymorhpism | - | CXCL5 gene variants and their relation to expression of CXCL5 protein in human CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013] | Chromosome | 4 |
| Location | 4q13.3 |
| Start | 74861359 |
| End | 74864446 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3088 |
| OMIM ID | 600324 |
| HGNC ID | HGNC:10642 |
| Unigene ID | Hs.89714 |
| Ensembl ID | - |
| PharmGKB ID | PA35573 |
mRNA Information
| mRNA ID | ?NM_002994.4 |
|---|---|
| Exon | join(1..257,392..524,635..718,1075..3088) | mRNA Sequence | Download Select all |
| Length | 2505 |
Protein Information
| Protein ID | NP_002985.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 114 |
| Uniprot ID | O95935 |
| Ensembl Protein ID | ENSP00000358677 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| L | Proteolytic Cleavage | 44 |
| E | Proteolytic Cleavage | 46 |
| A | Proteolytic Cleavage | 41 |
| A | Proteolytic Cleavage | 42 |
| V | Proteolytic Cleavage | 43 |
| N | Proteolytic Cleavage | 65 |
| C | Proteolytic Cleavage | 75 |
| S | Proteolytic Cleavage | 83 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3577 | CXCR1 | 908 | NP_000625.1 | in vivo | 96 929 028 702 798 |
| 3579 | CXCR2 | 907 | NP_001548.1 | in vivo | 96 929 028 702 798 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Pertussis | hsa05133 |
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 46-107 | Chemokine_CXC |
| cl00134 | 46-107 | Chemokine superfamily |
| pfam00048 | 46-106 | IL8 |
| smart00199 | 46-106 | SCY |
| cd00169 | 51-107 | Chemokine |
| cd00271 | 40-106 | Chemokine_C |
Ontology Information
| HPRD ID | 7029 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.