CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24395653	2014	Cell line : - Source : - Sample Type : - No. of Sample : 720 cases of colorectal cancer Stage : -	real time RT-PCR and immunohistochemistry	Up-regulation	-	CXCR4 protein may be a potential biomarker for liver metastasis and an independent marker for survival in colorectal cancer. CXCR4 expression was elevated in colorectal cancer tissues compared to pericancerous tissues.

Gene Details

Chromosome 2 - NC_000002.12136114349..136118155, complement)
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Gene Type	protein coding
Gene Family	CD molecules, "GPCR / Class A : Chemokine receptors : C-X-C motif"
Description	This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Chromosome	2
Location	2q21
Start	136114349
End	136118155
Strand	-
Gene Sequence	>gi\|568815596:c136118155-136114349 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly AACTTCAGTTTGTTGGCTGCGGCAGCAGGTAGCAAAGTGACGCCGAGGGCCTGAGTGCTCCAGTAGCCAC CGCATCTGGAGAACCAGCGGTTACCATGGAGGGGATCAGTGTAAGTCCAGTTTCAACCTGCTTTGTCATA AATGTACAAACGTTTGAACTTAGAGCGCAGCCCCTCTCCGAGCGGGCAGAAGCGGCCAGGACATTGGAGG TACCCGTACTCCAAAAAAGGGTCACCGAAAGGAGTTTTCTTGACCATGCCTATATAGTGCGGGTGGGTGG GGGGGGAGCAGGATTGGAATCTTTTTCTCTGTGAGTCGAGGAGAAACGACTGGAAAGAGCGTTCCAGTGG CTGCATGTGTCTCCCCCTTGAGTCCCGCCGCGCGCGGCGGCTTGCACGCTGTTTGCAAACGTAAGAACAT TCTGTGCACAAGTGCAGAGAAGGCGTGCGCGCTGCCTCGGGACTCAGACCACCGGTCTCTTCCTTGGGGA AGCGGGGATGTCTTGGAGCGAGTTACATTGTCTGAATTTAGAGGCGGAGGGCGGCGTGCCTGGGCTGAGT TCCCAGGAGGAGATTGCGCCCGCTTTAACTTCGGGGTTAAGCGCCTGGTGACTGTTCTTGACACTGGGTG CGTGTTTGTTAAACTCTGTGCGGCCGACGGAGCTGTGCCAGTCTCCCAGCACAGTAGGCAGAGGGCGGGA GAGGCGGGTGGACCCACCGCGCCGATCCTCTGAGGGGATCGAGTGGTGGCAGCAGCTAGGAGTTGATCCG CCCGCGCGCTTTGGGTTTGAGGGGGAAAACCTTCCCGCCGTCCGAAGCGCGCCTCTTCCCCACGGCCGCG AGTGGGTCCTGCAGTTCGAGAGTTTGGGGTCGTGCAGAGGTCAGCGGAGTGGTTTGACCTCCCCTTTGAC ACCGCGCAGCTGCCAGCCCTGAGATTTGCGCTCCGGGGATAGGAGCGGGTACGGGGTGAGGGGCGGGGGC GGTTAAGACCGCACCTGGGCTGCCAGGTCGCCGCCGCGAAGACTGGCAGGTGCAAGTGGGGAAACCGTTT GGCTCTCTCCGAGTCCAGTTGTGATGTTTAACCGTCGGTGGTTTCCAGAAACCTTTTGAAACCCTCTTGC TAGGGAGTTTTTGGTTTCCTGCAGCGGCGCGCAATTCAAAGACGCTCGCGGCGGAGCCGCCCAGTCGCTC CCCAGCACCCTGTGGGACAGAGCCTGGCGTGTCGCCCAGCGGAGCCCCTGCAGCGCTGCTTGCGGGCGGT TGGCGTGGGTGTAGTGGGCAGCCGCGGCGGCCCGGGGCTGGACGACCCGGCCCCCCGCGTGCCCACCGCC TGGAGGCTTCCAGCTGCCCACCTCCGGCCGGGTTAACTGGATCAGTGGCGGGGTAATGGGAAGCCACCCG GGAGAGTGAGGAAATGAAACTTGGGGCGAGGACCACGGGTGCAGACCCCGTTACCTTCTCCACCCAGGAA AATGCCCCGCTCCCTAACGTCCCAAACGCGCCAAGTGATAAACACGAGGATGGCAAGAGACCCACACACC GGAGGAGCGCCCGCTTGGGGGAGGAGGTGCCGTTTGTTCATTTTCTGACACTCCCGCCCAATATACCCCA AGCACCGAAGGGCCTTCGTTTTAAGACCGCATTCTCTTTACCCACTACAAGTTGCTTGAAGCCCAGAATG GTTTGTATTTAGGCAGGCGTGGGAAAATTAAGTTTTTGCGCTTTAGGAGAATGAGTCTTTGCAACGCCCC CGCCCTCCCCCCGTGATCCTCCCTTCTCCCCTCTTCCCTCCCTGGGCGAAAAACTTCTTACAAAAAGTTA ATCACTGCCCCTCCTAGCAGCACCCACCCCACCCCCCACGCCGCCTGGGAGTGGCCTCTTTGTGTGTATT TTTTTTTTCCTCCTAAGGAAGGTTTTTTTTCTTCCCTCTAGTGGGCGGGGCAGAGGAGTTAGCCAAGATG TGACTTTGAAACCCTCAGCGTCTCAGTGCCCTTTTGTTCTAAACAAAGAATTTTGTAATTGGTTCTACCA AAGAAGGATATAATGAAGTCACTATGGGAAAAGATGGGGAGGAGAGTTGTAGGATTCTACATTAATTCTC TTGTGCCCTTAGCCCACTACTTCAGAATTTCCTGAAGAAAGCAAGCCTGAATTGGTTTTTTAAATTGCTT TAAAAATTTTTTTTAACTGGGTTAATGCTTGCTGAATTGGAAGTGAATGTCCATTCCTTTGCCTCTTTTG CAGATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGGACTATGACTCCATGAAGGAACCCT GTTTCCGTGAAGAAAATGCTAATTTCAATAAAATCTTCCTGCCCACCATCTACTCCATCATCTTCTTAAC TGGCATTGTGGGCAATGGATTGGTCATCCTGGTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGAC AAGTACAGGCTGCACCTGTCAGTGGCCGACCTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGATG CCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCCATGTCATCTACACAGTCAACCTCTA CAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCCATCGTCCACGCCACCAACAGT CAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTATGTTGGCGTCTGGATCCCTGCCCTCCTGCTGA CTATTCCCGACTTCATCTTTGCCAACGTCAGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCC CAATGACTTGTGGGTGGTTGTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTC ATCCTGTCCTGCTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAGGCCC TCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTACATTGGGATCAGCAT CGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTTGAGAACACTGTGCACAAGTGGATT TCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTGAACCCCATCCTCTATGCTTTCCTTGGAGCCA AATTTAAAACCTCTGCCCAGCACGCACTCACCTCTGTGAGCAGAGGGTCCAGCCTCAAGATCCTCTCCAA AGGAAAGCGAGGTGGACATTCATCTGTTTCCACTGAGTCTGAGTCTTCAAGTTTTCACTCCAGCTAACAC AGATGTAAAAGACTTTTTTTTATACGATAAATAACTTTTTTTTAAGTTACACATTTTTCAGATATAAAAG ACTGACCAATATTGTACAGTTTTTATTGCTTGTTGGATTTTTGTCTTGTGTTTCTTTAGTTTTTGTGAAG TTTAATTGACTTATTTATATAAATTTTTTTTGTTTCATATTGATGTGTGTCTAGGCAGGACCTGTGGCCA AGTTCTTAGTTGCTGTATGTCTCGTGGTAGGACTGTAGAAAAGGGAACTGAACATTCCAGAGCGTGTAGT GAATCACGTAAAGCTAGAAATGATCCCCAGCTGTTTATGCATAGATAATCTCTCCATTCCCGTGGAACGT TTTTCCTGTTCTTAAGACGTGATTTTGCTGTAGAAGATGGCACTTATAACCAAAGCCCAAAGTGGTATAG AAATGCTGGTTTTTCAGTTTTCAGGAGTGGGTTGATTTCAGCACCTACAGTGTACAGTCTTGTATTAAGT TGTTAATAAAAGTACATGTTAAACTTA Download Select all
Length	3807
OMIM ID	162643
HGNC ID	HGNC:2561
Unigene ID	Hs.593413
Ensembl ID	ENSG00000121966
PharmGKB ID	-

mRNA Information

mRNA ID	NM_003467.2
Exon	join(1..110,2244..3807)
mRNA Sequence	>7852 TTTTTTTTCTTCCCTCTAGTGGGCGGGGCAGAGGAGTTAGCCAAGATGTGACTTTGAAACCCTC AGCGTCTCAGTGCCCTTTTGTTCTAAACAAAGAATTTTGTAATTGGTTCTACCAAAGAAGGATA TAATGAAGTCACTATGGGAAAAGATGGGGAGGAGAGTTGTAGGATTCTACATTAATTCTCTTGT GCCCTTAGCCCACTACTTCAGAATTTCCTGAAGAAAGCAAGCCTGAATTGGTTTTTTAAATTGC TTTAAAAATTTTTTTTAACTGGGTTAATGCTTGCTGAATTGGAAGTGAATGTCCATTCCTTTGC CTCTTTTGCAGATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGGACTATGACTC CATGAAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAATAAAATCTTCCTGCCCACCATC TACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGATTGGTCATCCTGGTCATGGGTTACC AGAAGAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGTCAGTGGCCGACCTCCTCTT TGTCATCACGCTTCCCTTCTGGGCAGTTGATGCCGTGGCAAACTGGTACTTTGGGAACTTCCTA TGCAAGGCAGTCCATGTCATCTACACAGTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCA TCAGTCTGGACCGCTACCTGGCCATCGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTT GGCTGAAAAGGTGGTCTATGTTGGCGTCTGGATCCCTGCCCTCCTGCTGACTATTCCCGACTTC ATCTTTGCCAACGTCAGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCCCAATGACT TGTGGGTGGTTGTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTCAT CCTGTCCTGCTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAG GCCCTCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTACATTG GGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTTGAGAACAC TGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTGAACCCCATC CTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTCACCTCTGTGAGCA GAGGGTCCAGCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGACATTCATCTGTTTCCACTGA GTCTGAGTCTTCAAGTTTTCACTCCAGCTAACACAGATGTAAAAGACTTTTTTTTATACGATAA ATAACTTTTTTTTAAGTTACACATTTTTCAGATATAAAAGACTGACCAATATTGTACAGTTTTT ATTGCTTGTTGGATTTTTGTCTTGTGTTTCTTTAGTTTTTGTGAAGTTTAATTGACTTATTTAT ATAAATTTTTTTTGTTTCATATTGATGTGTGTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTTG CTGTATGTCTCGTGGTAGGACTGTAGAAAAGGGAACTGAACATTCCAGAGCGTGTAGTGAATCA CGTAAAGCTAGAAATGATCCCCAGCTGTTTATGCATAGATAATCTCTCCATTCCCGTGGAACGT TTTTCCTGTTCTTAAGACGTGATTTTGCTGTAGAAGATGGCACTTATAACCAAAGCCCAAAGTG GTATAGAAATGCTGGTTTTTCAGTTTTCAGGAGTGGGTTGATTTCAGCACCTACAGTGTACAGT CTTGTATTAAGTTGTTAATAAAAGTACATGTTAAACTTAAAAAAAAAAAAAAAAAA Download Select all
Length	1912

CDS Information

Location	join(96..110,2244..3287)
CDS Sequence	>lcl\|NM_001008540.1_cds_NP_001008540.1_1 [gene=CXCR4] [protein=C-X-C chemokine receptor type 4 isoform a] [protein_id=NP_001008540.1] [location=305..1375] ATGTCCATTCCTTTGCCTCTTTTGCAGATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGG ACTATGACTCCATGAAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAATAAAATCTTCCTGCCCAC CATCTACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGATTGGTCATCCTGGTCATGGGTTACCAG AAGAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGTCAGTGGCCGACCTCCTCTTTGTCATCA CGCTTCCCTTCTGGGCAGTTGATGCCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCCA TGTCATCTACACAGTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTG GCCATCGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTATGTTGGCG TCTGGATCCCTGCCCTCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTCAGTGAGGCAGATGACAG ATATATCTGTGACCGCTTCTACCCCAATGACTTGTGGGTGGTTGTGTTCCAGTTTCAGCACATCATGGTT GGCCTTATCCTGCCTGGTATTGTCATCCTGTCCTGCTATTGCATTATCATCTCCAAGCTGTCACACTCCA AGGGCCACCAGAAGCGCAAGGCCCTCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCT GCCTTACTACATTGGGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTT GAGAACACTGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTGAACCCCA TCCTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTCACCTCTGTGAGCAGAGG GTCCAGCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGACATTCATCTGTTTCCACTGAGTCTGAGTCT TCAAGTTTTCACTCCAGCTAA Download Select all
CCDS ID	CCDS46420.1

Protein Information

Protein ID	NP_001008540.1
Protein Name	chemokine (C-X-C motif) receptor 4
Molecular Wt. (Da)	40090
Protein Sequence	>7852 MSIPLPLLQIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSV LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDR FYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACW LPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHA LTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS Download Select all
Length	356
Uniprot ID	P25025
Ensembl Protein ID	ENSP00000319635

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Sulfation	18
Y	Sulfation	21
S	Sulfation	22
Y	Sulfation	25
N	Glycosylation	11
N	Glycosylation	15
S	Phosphorylation	346;-
S	Phosphorylation	350;-
S	Phosphorylation	348;-
S	Phosphorylation	352;-
S	Phosphorylation	352;-
S	Phosphorylation	356;-
S	Phosphorylation	321;-
S	Phosphorylation	325;-
T	Phosphorylation	318;-
S	Phosphorylation	329;-
T	Phosphorylation	322;-
S	Phosphorylation	325;-
S	Phosphorylation	324;-
S	Phosphorylation	328;-
S	Phosphorylation	319
S	Phosphorylation	323
S	Phosphorylation	351
S	Phosphorylation	355
S	Phosphorylation	5
Y	Phosphorylation	7
S	Phosphorylation	18

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
157	ADRBK2	183	NP_005151.2	in vitro;in vivo	11668182
2770	GNAI1	756	NP_002060.4	in vivo	10506573
3717	JAK2	993	NP_004963.1	in vitro	10506573
4627	MYH9	1177	NP_002464.1	in vitro	12421915
5747	PTK2	2859	NP_005598.3	in vitro;in vivo	11668182
5781	PTPN11	1470	NP_002825.3	in vivo	11157475
5788	PTPRC	1050	NP_002829.2	in vivo	12519755
6385	SDC4	8366	NP_002990.2	in vivo	15819887
7409	VAV1	1284	NP_005419.2	in vivo	15618472
10672	GNA13	5100	NP_006563.2	in vivo	11994484

Pathway Information

Pathway Name	Pathway ID
Axon guidance	hsa04360
Chemokine signaling pathway	hsa04062
Cytokine-cytokine receptor interaction	hsa04060
Endocytosis	hsa04144
Intestinal immune network for IgA production	hsa04672
Leukocyte transendothelial migration	hsa04670
Pathways in cancer	hsa05200

Structure Information

PDB ID	2K03
Resolution
Method	SOLUTION NMR
Chains	B, D
Molecule	C-X-C chemokine receptor type 4
Model	View

Domain Information

ID	Location	Description
pfam12109	Jun-38	CXCR4_N
cl13535	Jun-38	CXCR4_N superfamily
pfam00001	61-302	7tm_1
PHA03087	4-332	PHA03087
PHA02638	23-310	PHA02638
PHA02834	40-310	PHA02834
PHA03235	12-311	PHA03235
PHA03234	61-310	PHA03234

Ontology Information

HPRD ID	2965
Molecular Class	G protein coupled receptor
Molecular Function	Transmembrane receptor activity (GO:0004888)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report

Uniprot ID	DrugBank ID	Name	Type
P61073	DB00452	Framycetin	SmallMoleculeDrug
P61073	DB06809	Plerixafor	SmallMoleculeDrug

CoReCG

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General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO