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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCR5 | 643 | chemokine (C-X-C motif) receptor 5 | 11 | MDR15, CD185 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25010623 | 2014 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 144 Stage : TNM Stage III,IV | Immunohistochemistry | Up-regulation | - | CXCR5 and CXCL13 may play a crucial role in the development, metastasis and relapse of advanced colon cancer. |
| 25726157 | 2015 | Cell line : - Source : Wuxi 4th People's Hospital Jiangsu. Sample Type : Tissue specimen No. of Sample : 236 paired CRC and normal tissues, 62 colorectal adenoma tissues Stage : TNM Stage I-IV. | Immunohistochemistry | Up-regulation | - | The expression of�CXCR5�and MMP-13 could promote the pathogenesis, development, metastasis, and relapse of�colorectal cancer.� |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "GPCR / Class A : Chemokine receptors : C-X-C motif" |
| Description | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | Chromosome | 11 |
| Location | 11q23.3 |
| Start | 118754475 |
| End | 118766980 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12506 |
| OMIM ID | 601613 |
| HGNC ID | HGNC:1060 |
| Unigene ID | Hs.113916 |
| Ensembl ID | ENSG00000160683 |
| PharmGKB ID | PA162383046 |
mRNA Information
| mRNA ID | NM_001716.4 |
|---|---|
| Exon | join(1..227,9831..12506) | mRNA Sequence | Download Select all |
| Length | 2919 |
Protein Information
| Protein ID | NP_001707.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) receptor 5 |
| Molecular Wt. (Da) | 41824 |
| Protein Sequence | Download Select all |
| Length | 372 |
| Uniprot ID | P24347 |
| Ensembl Protein ID | ENSP00000215743 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 74-322 | 7tm_1 |
| PHA03087 | 56-337 | PHA03087 |
| PHA02638 | 53-363 | PHA02638 |
| PHA02834 | 53-339 | PHA02834 |
| PHA03235 | 25-329 | PHA03235 |
| PHA03234 | 70-330 | PHA03234 |
Ontology Information
| HPRD ID | 3027 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.