Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CYLD | 1540 | cylindromatosis (turban tumor syndrome) | 16 | KIAA0849, USPL2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24577083 | 2014 | Cell line : HCT116,SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting,Immunoprecipitation,Chromatin immunoprecepetaion,transfection,siRNA transfection,Flow cytometry,real time RT-PCR,Immunohistochemistry | Down-regulation | - | LEF1-binding site in the CYLD promoter as a potential target for combinational therapy as an alternative to cIAPs. |
| 25824771 | 2015 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Luciferase reporter assays | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16q12-q13 |
| Start | 50775961 |
| End | 50835847 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 59887 |
| OMIM ID | 605018 |
| HGNC ID | HGNC:2584 |
| Unigene ID | Hs.578973 |
| Ensembl ID | - |
| PharmGKB ID | PA27084 |
mRNA Information
| mRNA ID | NM_015247.2 |
|---|---|
| Exon | join(1..75,713..792,2681..2817,7527..8153,9555..9857, 12270..12375,33117..33125,34130..34228,35776..35892, 37616..37995,39197..39362,40276..40417,42280..42402, 44806..44897,45737..45803,49509..49641,50548..50656, 51497..51615,52163..52379,54275..59886) | mRNA Sequence | Download Select all |
| Length | 8730 |
Protein Information
| Protein ID | NP_056062.1 |
|---|---|
| Protein Name | cylindromatosis (turban tumor syndrome) |
| Molecular Wt. (Da) | 107185 |
| Protein Sequence | Download Select all |
| Length | 956 |
| Uniprot ID | P36952 |
| Ensembl Protein ID | ENSP00000372221 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 399;- |
| S | Phosphorylation | 396;- |
| S | Phosphorylation | 396;- |
| T | Phosphorylation | 393 |
| T | Phosphorylation | 390 |
| T | Phosphorylation | 390 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vitro | 12917691 |
| 8517 | IKBKG | 2217 | NP_001093326.2 | in vitro | 15341735 |
| 10293 | TRAIP | 5811 | NP_005870.2 | in vitro;in vivo;yeast 2-hybrid | 14676304 |
| 23586 | DDX58 | 13131 | NP_055129.2 | in vitro;in vivo | 18636086 |
| 84231 | TRAF7 | 6977 | NP_115647.2 | in vivo | 16230348 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Osteoclast differentiation | hsa04380 |
| RIG-I-like receptor signaling pathway | hsa04622 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02670 | 593-948 | Peptidase_C19N |
| cl02553 | 593-948 | Peptidase_C19 superfamily |
| smart01052 | 472-540 | CAP_GLY |
| cl08315 | 472-540 | CAP_GLY superfamily |
| smart01052 | 127-203 | CAP_GLY |
| cl08315 | 127-203 | CAP_GLY superfamily |
| pfam01302 | 472-540 | CAP_GLY |
| pfam01302 | 127-203 | CAP_GLY |
| cd02257 | 593-948 | Peptidase_C19 |
| smart01052 | 232-302 | CAP_GLY |
| cl08315 | 232-302 | CAP_GLY superfamily |
| pfam01302 | 232-303 | CAP_GLY |
| COG5244 | 485-586 | NIP100 |
| COG5244 | 138-205 | NIP100 |
Ontology Information
| HPRD ID | 16416 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Lipid kinase activity (GO:0001727) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.