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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP1A1 1543 cytochrome P450, family 1, subfamily A, polypeptide 1  15P450DX, P1-450, P450-C, CP11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24939416   2014Cell line : -

Source : 2nd Department of General and Oncological Surgery and 1st Department of General Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Lower Silesia.

Sample Type : Blood sample

No. of Sample : 478

Stage : -

PCR-RFLPPolymorhpism-CYP1A1 Ile462Val was statistically significant in CRC patients over 50 years old.


Gene Details



NC_000015.9 (75011883..75017951, complement)

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Gene Type protein coding
Gene Family Cytochrome P450s
Description This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]  
Chromosome 15
Location 15q24.1
Start 75011883  
End 75017951  
Strand -  
Gene Sequence

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Length 6069  
OMIM ID 108330   
HGNC ID HGNC:2595   
Unigene ID Hs.72912   
Ensembl ID ENSG00000140465   
PharmGKB ID PA27092   

mRNA Information


mRNA ID NM_000499.4
Exon join(75..170,2488..3338,3894..4020,4108..4197,4289..4412, 4558..4644,4837..6069)  
mRNA Sequence

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Length 2701  



CDS Information


   
Location197..1735
CDS Sequence

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CCDS ID CCDS10268.1



Protein Information


      
Protein IDNP_000490.1
Protein Namecytochrome P450, family 1, subfamily A, polypeptide 1
Molecular Wt. (Da)58034
Protein Sequence

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Length 512  
Uniprot IDP01833
Ensembl Protein ID ENSP00000348888  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation360;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Chemical carcinogenesis hsa05204
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Ovarian steroidogenesis hsa04913
Retinol metabolism hsa00830
Steroid hormone biosynthesis hsa00140
Tryptophan metabolism hsa00380


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0006740-493  p450
cl1207840-493  p450 superfamily
PLN0311213-501  PLN03112
PLN0268710-501  PLN02687
PLN0011011-501  PLN00110
PTZ0040413-499  PTZ00404
PLN0218312-501  PLN02183
PLN0239412-491  PLN02394
PLN0323412-498  PLN03234
PLN0296611-508  PLN02966
PLN001687-491  PLN00168
COG212440-483  CypX
PLN0265545-497  PLN02655
PLN0297114-483  PLN02971
PLN0301829-476  PLN03018
PLN02936278-491  PLN02936
PLN02774296-477  PLN02774
PLN02290237-482  PLN02290
PLN02302280-475  PLN02302
PLN029877-477  PLN02987
PLN0219613-482  PLN02196
PLN02169303-501  PLN02169
PLN03141234-471  PLN03141
TIGR04538234-477  P450_cycloAA_1
PLN03195252-500  PLN03195
PLN02500302-471  PLN02500
PLN02426302-463  PLN02426
PLN02648304-438  PLN02648
PLN02738237-491  PLN02738


Ontology Information


   
HPRD ID1382
Molecular ClassEnzyme: Hydroxylase
Molecular FunctionLipid kinase activity (GO:0001727)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


Uniprot ID DrugBank ID Name Type
P04798DB00162Vitamin ASmallMoleculeDrug
P04798DB00165PyridoxineSmallMoleculeDrug
P04798DB00169CholecalciferolSmallMoleculeDrug
P04798DB00170MenadioneSmallMoleculeDrug
P04798DB00176FluvoxamineSmallMoleculeDrug
P04798DB00184NicotineSmallMoleculeDrug
P04798DB00188BortezomibSmallMoleculeDrug
P04798DB00201CaffeineSmallMoleculeDrug
P04798DB00203SildenafilSmallMoleculeDrug
P04798DB00208TiclopidineSmallMoleculeDrug
P04798DB00277TheophyllineSmallMoleculeDrug
P04798DB00316AcetaminophenSmallMoleculeDrug
P04798DB00317GefitinibSmallMoleculeDrug
P04798DB00325NitroprussideSmallMoleculeDrug
P04798DB00338OmeprazoleSmallMoleculeDrug
P04798DB00356ChlorzoxazoneSmallMoleculeDrug
P04798DB00363ClozapineSmallMoleculeDrug
P04798DB00381AmlodipineSmallMoleculeDrug
P04798DB00396ProgesteroneSmallMoleculeDrug
P04798DB00428StreptozocinSmallMoleculeDrug
P04798DB00448LansoprazoleSmallMoleculeDrug
P04798DB00457PrazosinSmallMoleculeDrug
P04798DB00468QuinineSmallMoleculeDrug
P04798DB00470DronabinolSmallMoleculeDrug
P04798DB00499FlutamideSmallMoleculeDrug
P04798DB00502HaloperidolSmallMoleculeDrug
P04798DB00518AlbendazoleSmallMoleculeDrug
P04798DB00526OxaliplatinSmallMoleculeDrug
P04798DB00530ErlotinibSmallMoleculeDrug
P04798DB00539ToremifeneSmallMoleculeDrug
P04798DB00553MethoxsalenSmallMoleculeDrug
P04798DB00568CinnarizineSmallMoleculeDrug
P04798DB00571PropranololSmallMoleculeDrug
P04798DB00575ClonidineSmallMoleculeDrug
P04798DB00586DiclofenacSmallMoleculeDrug
P04798DB00605SulindacSmallMoleculeDrug
P04798DB00608ChloroquineSmallMoleculeDrug
P04798DB00613AmodiaquineSmallMoleculeDrug
P04798DB00624TestosteroneSmallMoleculeDrug
P04798DB00633DexmedetomidineSmallMoleculeDrug
P04798DB00636ClofibrateSmallMoleculeDrug
P04798DB00643MebendazoleSmallMoleculeDrug
P04798DB00655EstroneSmallMoleculeDrug
P04798DB00675TamoxifenSmallMoleculeDrug
P04798DB00682WarfarinSmallMoleculeDrug
P04798DB00693FluoresceinSmallMoleculeDrug
P04798DB00694DaunorubicinSmallMoleculeDrug
P04798DB00730ThiabendazoleSmallMoleculeDrug
P04798DB00738PentamidineSmallMoleculeDrug
P04798DB00740RiluzoleSmallMoleculeDrug
P04798DB00755TretinoinSmallMoleculeDrug
P04798DB00783EstradiolSmallMoleculeDrug
P04798DB00804DicyclomineSmallMoleculeDrug
P04798DB00818PropofolSmallMoleculeDrug
P04798DB00851DacarbazineSmallMoleculeDrug
P04798DB00882ClomifeneSmallMoleculeDrug
P04798DB00889GranisetronSmallMoleculeDrug
P04798DB00898EthanolSmallMoleculeDrug
P04798DB00908QuinidineSmallMoleculeDrug
P04798DB00972AzelastineSmallMoleculeDrug
P04798DB01013Clobetasol propionateSmallMoleculeDrug
P04798DB01026KetoconazoleSmallMoleculeDrug
P04798DB01041ThalidomideSmallMoleculeDrug
P04798DB01059NorfloxacinSmallMoleculeDrug
P04798DB01064IsoprenalineSmallMoleculeDrug
P04798DB01065MelatoninSmallMoleculeDrug
P04798DB01087PrimaquineSmallMoleculeDrug
P04798DB01092OuabainSmallMoleculeDrug
P04798DB01095FluvastatinSmallMoleculeDrug
P04798DB01115NifedipineSmallMoleculeDrug
P04798DB01118AmiodaroneSmallMoleculeDrug
P04798DB01129RabeprazoleSmallMoleculeDrug
P04798DB01136CarvedilolSmallMoleculeDrug
P04798DB01167ItraconazoleSmallMoleculeDrug
P04798DB01169Arsenic trioxideSmallMoleculeDrug
P04798DB01174PhenobarbitalSmallMoleculeDrug
P04798DB01234DexamethasoneSmallMoleculeDrug
P04798DB01254DasatinibSmallMoleculeDrug
P04798DB01393BezafibrateSmallMoleculeDrug
P04798DB01407ClenbuterolSmallMoleculeDrug
P04798DB04840DebrisoquinSmallMoleculeDrug
P04798DB04841FlunarizineSmallMoleculeDrug
P04798DB04871LorcaserinSmallMoleculeDrug
P04798DB06292DapagliflozinSmallMoleculeDrug
P04798DB06770Benzyl alcoholSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO